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Kif5a kinesin family member 5A [ Mus musculus (house mouse) ]

Gene ID: 16572, updated on 30-May-2016
Official Symbol
Kif5aprovided by MGI
Official Full Name
kinesin family member 5Aprovided by MGI
Primary source
MGI:MGI:109564
See related
Ensembl:ENSMUSG00000074657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Khc; Kns; Kif5; mKIAA4086; D10Bwg0738e
Orthologs
Location:
10 D3; 10 74.5 cM
Exon count:
29
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (127225695..127263363, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (126662751..126700419, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA F420014N23 gene Neighboring gene deltex 3, E3 ubiquitin ligase Neighboring gene phosphatidylinositol-5-phosphate 4-kinase, type II, gamma Neighboring gene predicted gene, 40801 Neighboring gene predicted gene, 40800 Neighboring gene dynactin 2 Neighboring gene methyl-CpG binding domain protein 6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA4086

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP-dependent microtubule motor activity, plus-end-directed IBA
Inferred from Biological aspect of Ancestor
more info
 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule motor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
protein localization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
axon ISO
Inferred from Sequence Orthology
more info
 
ciliary rootlet IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
kinesin complex ISO
Inferred from Sequence Orthology
more info
 
kinesin complex TAS
Traceable Author Statement
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
kinesin heavy chain isoform 5A
Names
NKHC
kinesin heavy chain neuron-specific 1
neuronal kinesin heavy chain

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039000.4NP_001034089.1  kinesin heavy chain isoform 5A

    See identical proteins and their annotated locations for NP_001034089.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer and the predominant transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK140769, AK147707, BC028563, BC058396
    Consensus CDS
    CCDS24233.1
    UniProtKB/Swiss-Prot
    P33175
    UniProtKB/TrEMBL
    Q3US62
    Related
    ENSMUSP00000096775, ENSMUST00000099172
    Conserved Domains (5) summary
    smart00129
    Location:9334
    KISc; Kinesin motor, catalytic domain. ATPase
    pfam06160
    Location:414904
    EzrA; Septation ring formation regulator, EzrA
    cd14798
    Location:441493
    RX-CC_like; Coiled-coil domain of the potato virux X resistance protein and similar proteins
    cl12013
    Location:637809
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cd01369
    Location:7327
    KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup
  2. NM_008447.4NP_032473.2  kinesin heavy chain isoform 5A

    See identical proteins and their annotated locations for NP_032473.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC144852, AK140769, BC058396
    Consensus CDS
    CCDS24233.1
    UniProtKB/Swiss-Prot
    P33175
    UniProtKB/TrEMBL
    Q3US62
    Conserved Domains (5) summary
    smart00129
    Location:9334
    KISc; Kinesin motor, catalytic domain. ATPase
    pfam06160
    Location:414904
    EzrA; Septation ring formation regulator, EzrA
    cd14798
    Location:441493
    RX-CC_like; Coiled-coil domain of the potato virux X resistance protein and similar proteins
    cl12013
    Location:637809
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cd01369
    Location:7327
    KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

    Range
    127225695..127263363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000032.1 Alternate Mm_Celera

    Range
    129618645..129655868 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)