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Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 [ Mus musculus (house mouse) ]

Gene ID: 16535, updated on 26-Aug-2014
Official Symbol
Kcnq1provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily Q, member 1provided by MGI
Primary source
MGI:108083
See related
Ensembl:ENSMUSG00000009545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kcna9; KVLQT1; AW559127
See Kcnq1 in Epigenomics, MapViewer
Location:
7 F5; 7 88.12 cM
Exon count:
19
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 7 NC_000073.6 (143106840..143427044)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene tumor-suppressing subchromosomal transferable fragment 4 Neighboring gene transient receptor potential cation channel, subfamily M, member 5 Neighboring gene KCNQ1 overlapping transcript 1 Neighboring gene RIKEN cDNA 4933417O13 gene Neighboring gene uncharacterized LOC102636511 Neighboring gene uncharacterized LOC102636658 Neighboring gene cyclin-dependent kinase inhibitor 1C (P57)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Cholinergic synapse, organism-specific biosystem (from KEGG)
    Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
  • Gastric acid secretion, organism-specific biosystem (from KEGG)
    Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Gastric acid secretion, conserved biosystem (from KEGG)
    Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Pancreatic secretion, organism-specific biosystem (from KEGG)
    Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Pancreatic secretion, conserved biosystem (from KEGG)
    Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Potassium Channels, organism-specific biosystem (from REACTOME)
    Potassium Channels, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Protein digestion and absorption, organism-specific biosystem (from KEGG)
    Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
  • Protein digestion and absorption, conserved biosystem (from KEGG)
    Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
  • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
  • TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem
    TNF-alpha NF-kB Signaling Pathway
  • Voltage gated Potassium channels, organism-specific biosystem (from REACTOME)
    Voltage gated Potassium channels, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
ion channel activity IEA
Inferred from Electronic Annotation
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
outward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase A catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase 1 binding ISO
Inferred from Sequence Orthology
more info
 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization ISO
Inferred from Sequence Orthology
more info
 
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization ISO
Inferred from Sequence Orthology
more info
 
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
atrial cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
cardiovascular system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
cellular response to drug ISO
Inferred from Sequence Orthology
more info
 
gene silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion transport IEA
Inferred from Electronic Annotation
more info
 
membrane repolarization during action potential ISO
Inferred from Sequence Orthology
more info
 
membrane repolarization during cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gastric acid secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
potassium ion export ISO
Inferred from Sequence Orthology
more info
 
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
regulation of atrial cardiac muscle cell membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression by genetic imprinting IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
regulation of ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
regulation of membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
regulation of ventricular cardiac muscle cell membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
response to anesthetic ISO
Inferred from Sequence Orthology
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
ventricular cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
late endosome ISO
Inferred from Sequence Orthology
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 
voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
zymogen granule membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
potassium voltage-gated channel subfamily KQT member 1
Names
potassium voltage-gated channel subfamily KQT member 1
KQT-like 1
voltage-gated potassium channel subunit Kv7.1
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008434.2NP_032460.2  potassium voltage-gated channel subfamily KQT member 1

    See proteins identical to NP_032460.2

    Status: VALIDATED

    Source sequence(s)
    BC045142, BC055304
    Consensus CDS
    CCDS22039.1
    UniProtKB/Swiss-Prot
    P97414
    Related
    ENSMUSP00000009689, ENSMUST00000009689
    Conserved Domains (3) summary
    pfam00520
    Location:157346
    Blast Score: 237
    Ion_trans; Ion transport protein
    pfam03520
    Location:450623
    Blast Score: 680
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:269347
    Blast Score: 151
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000073.6 

    Range
    143106840..143427044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508492.1XP_006508555.1  

    Conserved Domains (3) summary
    pfam00520
    Location:45234
    Blast Score: 225
    Ion_trans; Ion transport protein
    pfam03520
    Location:338511
    Blast Score: 684
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:157235
    Blast Score: 148
    Ion_trans_2; Ion channel
  2. XM_006508489.1XP_006508552.1  

    Conserved Domains (3) summary
    pfam00520
    Location:231420
    Blast Score: 237
    Ion_trans; Ion transport protein
    pfam03520
    Location:524578
    Blast Score: 163
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:343421
    Blast Score: 148
    Ion_trans_2; Ion channel
  3. XM_006508491.1XP_006508554.1  

    See proteins identical to XP_006508554.1

    Conserved Domains (3) summary
    pfam00520
    Location:211400
    Blast Score: 236
    Ion_trans; Ion transport protein
    pfam03520
    Location:504558
    Blast Score: 163
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:323401
    Blast Score: 148
    Ion_trans_2; Ion channel
  4. XM_006508490.1XP_006508553.1  

    See proteins identical to XP_006508553.1

    Conserved Domains (3) summary
    pfam00520
    Location:211400
    Blast Score: 236
    Ion_trans; Ion transport protein
    pfam03520
    Location:504558
    Blast Score: 163
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:323401
    Blast Score: 148
    Ion_trans_2; Ion channel
  5. XM_006508488.1XP_006508551.1  

    Conserved Domains (3) summary
    pfam00520
    Location:231420
    Blast Score: 246
    Ion_trans; Ion transport protein
    pfam03520
    Location:524697
    Blast Score: 678
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:343421
    Blast Score: 155
    Ion_trans_2; Ion channel
  6. XM_006508493.1XP_006508556.1  

    See proteins identical to XP_006508556.1

    Conserved Domains (3) summary
    pfam00520
    Location:1189
    Blast Score: 229
    Ion_trans; Ion transport protein
    pfam03520
    Location:293466
    Blast Score: 678
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:112190
    Blast Score: 152
    Ion_trans_2; Ion channel

Alternate Mm_Celera

Genomic

  1. AC_000029.1 

    Range
    142862859..143182707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)