Kcnn4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Kcnn4provided by MGI
Official Full Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4provided by MGI
Primary source: MGI:1277957
See related: Ensembl:ENSMUSG00000054342
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IK1; SK4; KCA4; IKCA1; SKCas; KCa3.1; mIKCa1

Genomic context

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Location :: 7 A3; 7

Sequence :: Chromosome: 7; NC_000073.6 (24370263..24385212)

See Kcnn4 in Epigenomics, MapViewer

Chromosome 7 - NC_000073.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

The inhibition of KCa3.1 channels activity reduces cell motility in glioblastoma derived cancer stem cells.
Title: The inhibition of KCa3.1 channels activity reduces cell motility in glioblastoma derived cancer stem cells.
Genetic KCa3.1-deficiency causes locomotor hyperactivity and altered monoamine levels in selected brain regions
Title: Genetic KCa3.1-deficiency produces locomotor hyperactivity and alterations in cerebral monoamine levels.
KCa3.1 channels are involved in the pathogenesis of obliterative airway disease (OAD). KCa3.1 blockade holds promise to reduce OAD development.
Title: The potassium channel KCa3.1 as new therapeutic target for the prevention of obliterative airway disease.
Modafinil inhibits K(Ca)3.1 channels and vascular smooth muscle contraction by cAMP-dependent phosphorylation.
Title: Modafinil inhibits K(Ca)3.1 currents and muscle contraction via a cAMP-dependent mechanism.
These results demonstrate that three functional ion channel currents, I(KCa), I(Cl.vol), and I(Kir), are heterogeneously present in 3T3-L1 preadipocytes. I(KCa) and I(Cl.vol) participate in the regulation of cell proliferation.
Title: Functional ion channels and cell proliferation in 3T3-L1 preadipocytes.
KCa3.1 expression in lung dendritic cells was up-regulated by ovalbumin sensitization. KCa3.1 was involved in the migration of lung dendritic cells to lymphatic chemokines.
Title: Calcium-activated potassium channel KCa3.1 in lung dendritic cell migration.
Ca2+ activated K+ channel Kca3.1 plays a central role in gastric acid secretion.
Title: Ca2+ activated K+ channel Kca3.1 as a determinant of gastric acid secretion.
the N-terminal domain of K(Ca)3.1 is critical for channel trafficking to the plasma membrane
Title: Involvement of dominant-negative spliced variants of the intermediate conductance Ca2+-activated K+ channel, K(Ca)3.1, in immune function of lymphoid cells.
Globotriaosylceramide evokes K(Ca)3.1 channel dysfunction, and the channel dysfunction in vascular endothelial cells may contribute to vasculopathy in Fabry disease.
Title: Globotriaosylceramide leads to K(Ca)3.1 channel dysfunction: a new insight into endothelial dysfunction in Fabry disease.
The SK4 component of the Kslow current can trigger oscillations in mice without functioning KATP channels.
Title: Physiological significance of SK4 channels in pancreatic β-cell oscillations.

Submit: New GeneRIF Correction See all (33)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (3) 1 citation

Pathways from BioSystems

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Ca2+ activated K+ channels, organism-specific biosystem (from REACTOME)
Ca2+ activated K+ channels, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Insulin secretion, organism-specific biosystem (from KEGG)
Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
Neuronal System, organism-specific biosystem (from REACTOME)
Neuronal System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Potassium Channels, organism-specific biosystem (from REACTOME)
Potassium Channels, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Protein digestion and absorption, organism-specific biosystem (from KEGG)
Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
Protein digestion and absorption, conserved biosystem (from KEGG)
Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
Salivary secretion, organism-specific biosystem (from KEGG)
Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
Salivary secretion, conserved biosystem (from KEGG)
Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...

General gene information

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Markers

Kcnn4 (e-PCR), detects polymorphism
- UniSTS:143673

AF042487 (e-PCR)
- UniSTS:163411

Kcnn4 (e-PCR), detects polymorphism
- UniSTS:507006

Homology

Homologs of the Kcnn4 gene: The Kcnn4 gene is conserved in human, chimpanzee, Rhesus monkey, dog, rat, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
Intermediate conductance calcium-activated potassium channel activity	ISO Inferred from Sequence Orthology more info
calcium-activated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
calcium-activated potassium channel activity	ISO Inferred from Sequence Orthology more info
calmodulin binding	IEA Inferred from Electronic Annotation more info
ion channel activity	IEA Inferred from Electronic Annotation more info
potassium channel activity	IGI Inferred from Genetic Interaction more info	PubMed
protein phosphatase binding	ISO Inferred from Sequence Orthology more info
small conductance calcium-activated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
anion transport	ISO Inferred from Sequence Orthology more info
calcium ion transport	ISO Inferred from Sequence Orthology more info
cell volume homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
ion transmembrane transport	IEA Inferred from Electronic Annotation more info
ion transport	IEA Inferred from Electronic Annotation more info
phospholipid translocation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of protein secretion	IDA Inferred from Direct Assay more info	PubMed
potassium ion export	ISO Inferred from Sequence Orthology more info
potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
potassium ion transport	ISO Inferred from Sequence Orthology more info
saliva secretion	IGI Inferred from Genetic Interaction more info	PubMed
stabilization of membrane potential	ISO Inferred from Sequence Orthology more info
transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
apical plasma membrane	ISO Inferred from Sequence Orthology more info
basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
integral to membrane	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	IC Inferred by Curator more info	PubMed
membrane	IEA Inferred from Electronic Annotation more info
membrane raft	ISO Inferred from Sequence Orthology more info
neuronal cell body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: intermediate conductance calcium-activated potassium channel protein 4

Names: intermediate conductance calcium-activated potassium channel protein 4; SKCa4; SKCa 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163510.1 → NP_001156982.1 intermediate conductance calcium-activated potassium channel protein 4

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an additional segment in the 3' UTR, compared to variant 1.

Source sequence(s)

AK010943, AK155910, BX639773

Consensus CDS

CCDS20948.1

UniProtKB/Swiss-Prot

O89109

Related

ENSMUSP00000133065, ENSMUST00000171904

Conserved Domains (3) summary

pfam02888
Location:302 – 374
Blast Score: 280

CaMBD; Calmodulin binding domain

pfam03530
Location:25 – 121
Blast Score: 371

SK_channel; Calcium-activated SK potassium channel

pfam07885
Location:218 – 276
Blast Score: 134

Ion_trans_2; Ion channel
NM_008433.4 → NP_032459.3 intermediate conductance calcium-activated potassium channel protein 4

Status: VALIDATED

Description

Transcript Variant: This variant (1) and variant 2 encode the same protein.

Source sequence(s)

AK010943, AK085752, AK155910, BX639773

Consensus CDS

CCDS20948.1

UniProtKB/Swiss-Prot

O89109

Conserved Domains (3) summary

pfam02888
Location:302 – 374
Blast Score: 280

CaMBD; Calmodulin binding domain

pfam03530
Location:25 – 121
Blast Score: 371

SK_channel; Calcium-activated SK potassium channel

pfam07885
Location:218 – 276
Blast Score: 134

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000073.6 Reference GRCm38.p1 C57BL/6J

Range

24370263..24385212

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000029.1 Alternate Mm_Celera

Range

18994758..19009501

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01059958.1 (59358..74101)	None
genomic	AC159140.10 (55034..69980)	None
genomic	CH466593.2	EDL24340.1	mixed
		EDL24341.1	mixed
		EDL24342.1	mixed
		EDL24343.1	mixed
genomic	HC874395.1	CBM42812.1
mRNA	AB128930.1	BAI52724.1
mRNA	AF042487.1	AAC32051.1	CD-1
mRNA	AF072884.1	AAC32829.1
mRNA	AK010943.1	BAB27283.1	C57BL/6J
mRNA	AK038253.1	None	C57BL/6J
mRNA	AK085752.1	None	C57BL/6J
mRNA	AK088778.1	BAC40567.1	NOD
mRNA	AK155910.1	BAE33499.1	C57BL/6J
mRNA	BC010274.1	AAH10274.1	CZECHII
mRNA	BX639773.1	None
mRNA	BY197732.1	None	C57BL/6J