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Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 [ Mus musculus (house mouse) ]

Gene ID: 16514, updated on 18-Apr-2015
Official Symbol
Kcnj11provided by MGI
Official Full Name
potassium inwardly rectifying channel, subfamily J, member 11provided by MGI
Primary source
MGI:MGI:107501
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mBIR; Kir6.2
Orthologs
See Kcnj11 in MapViewer
Location:
7 B4; 7 29.66 cM
Exon count:
2
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (46097123..46100872, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (53352532..53355607, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene nodal modulator 1 Neighboring gene predicted gene, 39010 Neighboring gene erythrocyte protein band 4.1-like 5 pseudogene Neighboring gene ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Neighboring gene Usher syndrome 1C

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP-activated inward rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
ATP-activated inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
ankyrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
ankyrin binding ISO
Inferred from Sequence Orthology
more info
 
heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
inward rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
potassium ion binding IC
Inferred by Curator
more info
PubMed 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
neurological system process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cation channel activity ISO
Inferred from Sequence Orthology
more info
 
potassium ion import IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
regulation of ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
response to ATP ISO
Inferred from Sequence Orthology
more info
 
response to drug ISO
Inferred from Sequence Orthology
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
ATP-sensitive potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
ATP-sensitive potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
T-tubule ISO
Inferred from Sequence Orthology
more info
 
axolemma ISO
Inferred from Sequence Orthology
more info
 
cell body fiber ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
intercalated disc ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
myelin sheath ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 
voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
ATP-sensitive inward rectifier potassium channel 11
Names
ATP-sensitive inward rectifier potassium channel 11
inward rectifier K(+) channel Kir6.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204411.1NP_001191340.1  ATP-sensitive inward rectifier potassium channel 11 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC115036
    Conserved Domains (1) summary
    pfam01007
    Location:1269
    IRK; Inward rectifier potassium channel
  2. NM_010602.3NP_034732.1  ATP-sensitive inward rectifier potassium channel 11 isoform 1

    See identical proteins and their annotated locations for NP_034732.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BB136650, BC052731
    Consensus CDS
    CCDS21274.1
    UniProtKB/Swiss-Prot
    Q61743
    Conserved Domains (1) summary
    pfam01007
    Location:36356
    IRK; Inward rectifier potassium channel

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    46097123..46100872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540663.2XP_006540726.1  

    Conserved Domains (1) summary
    pfam01007
    Location:1280
    IRK; Inward rectifier potassium channel

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    41570444..41574072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)