Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnj10provided by MGI
Official Full Name: potassium inwardly-rectifying channel, subfamily J, member 10provided by MGI
Primary source: MGI:MGI:1194504
See related: Ensembl:ENSMUSG00000044708 AllianceGenome:MGI:1194504
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BIR10; BIRK-1; Kir1.2; Kir4.1
Summary: Enables inward rectifier potassium channel activity. Involved in non-motile cilium assembly. Acts upstream of or within several processes, including adult walking behavior; ion transmembrane transport; and regulation of resting membrane potential. Located in astrocyte projection; basolateral plasma membrane; and cell body. Is active in ciliary base. Is expressed in several structures, including brain; genitourinary system; spinal cord; stomach; and stria vascularis. Used to study EAST syndrome. Human ortholog(s) of this gene implicated in EAST syndrome and autosomal recessive nonsyndromic deafness 4. Orthologous to human KCNJ10 (potassium inwardly rectifying channel subfamily J member 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 42.3), frontal lobe adult (RPKM 31.1) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 79.69 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (172168777..172201652)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (172341210..172374085)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal Tubules in Regulating Inwardly Rectifying Potassium Channels 4.2 (Kir4.2), Kir4.1, and Epithelial Na[+] Channel (ENaC).
Title: Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal Tubules in Regulating Inwardly Rectifying Potassium Channels 4.2 (Kir4.2), Kir4.1, and Epithelial Na(+) Channel (ENaC).
Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity.
Title: Nedd4-2-dependent regulation of astrocytic Kir4.1 and Connexin43 controls neuronal network activity.
Involvement of Kir4.1 in pain insensitivity of the BTBR mouse model of autism spectrum disorder.
Title: Involvement of Kir4.1 in pain insensitivity of the BTBR mouse model of autism spectrum disorder.
Spinal astrocytic MeCP2 regulates Kir4.1 for the maintenance of chronic hyperalgesia in neuropathic pain.
Title: Spinal astrocytic MeCP2 regulates Kir4.1 for the maintenance of chronic hyperalgesia in neuropathic pain.
The ribosome-associated protein RACK1 represses Kir4.1 translation in astrocytes and influences neuronal activity.
Title: The ribosome-associated protein RACK1 represses Kir4.1 translation in astrocytes and influences neuronal activity.
Dystrophin Short Product, Dp71, Interacts with AQP4 and Kir4.1 Channels in the Mouse Cerebellar Glial Cells in Contrast to Dp427 at Inhibitory Postsynapses in the Purkinje Neurons.
Title: Dystrophin Short Product, Dp71, Interacts with AQP4 and Kir4.1 Channels in the Mouse Cerebellar Glial Cells in Contrast to Dp427 at Inhibitory Postsynapses in the Purkinje Neurons.
Kir4.1 deletion prevents salt-sensitive hypertension in early streptozotocin-induced diabetic mice via Na + -Cl - cotransporter in the distal convoluted tubule.
Title: Kir4.1 deletion prevents salt-sensitive hypertension in early streptozotocin-induced diabetic mice via Na + -Cl - cotransporter in the distal convoluted tubule.
Astrocytic Kir4.1 channels regulate locomotion by orchestrating neuronal rhythmicity in the spinal network.
Title: Astrocytic Kir4.1 channels regulate locomotion by orchestrating neuronal rhythmicity in the spinal network.
Kir4.1 is specifically expressed and active in non-myelinating Schwann cells.
Title: Kir4.1 is specifically expressed and active in non-myelinating Schwann cells.
Kir4.1 channel activation in NG2 glia contributes to remyelination in ischemic stroke.
Title: Kir4.1 channel activation in NG2 glia contributes to remyelination in ischemic stroke.

Submit: New GeneRIF Correction See all GeneRIFs (71)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G64928 (e-PCR)
- UniSTS:225849

G42037 (e-PCR)
- UniSTS:105062

G42040 (e-PCR)
- UniSTS:105065

G42061 (e-PCR)
- UniSTS:105079

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables inward rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables inward rectifier potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables inward rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-glutamate import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to potassium ion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within central nervous system myelination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glutamate reuptake	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane hyperpolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oligodendrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within potassium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of resting membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within visual perception	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in astrocyte projection	IDA Inferred from Direct Assay more info	PubMed
located_in astrocyte projection	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in ciliary base	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ATP-sensitive inward rectifier potassium channel 10

Names: inward rectifier K(+) channel Kir4.1; potassium channel, inwardly rectifying subfamily J member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039484.1 → NP_001034573.1 ATP-sensitive inward rectifier potassium channel 10

See identical proteins and their annotated locations for NP_001034573.1

Status: VALIDATED

Source sequence(s)

AC074311, AK044640, AK048864

Consensus CDS

CCDS15512.1

UniProtKB/Swiss-Prot

Q9JM63

UniProtKB/TrEMBL

B9EIV1, Q56VN0

Related

ENSMUSP00000054356.4, ENSMUST00000056136.4

Conserved Domains (2) summary

pfam01007
Location:31 → 172

IRK; Inward rectifier potassium channel

pfam17655
Location:179 → 354

IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

172168777..172201652

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496677.5 → XP_006496740.3 ATP-sensitive inward rectifier potassium channel 10 isoform X1

UniProtKB/TrEMBL

Q499F6

Conserved Domains (2) summary

pfam01007
Location:129 → 269

IRK; Inward rectifier potassium channel

pfam17655
Location:276 → 451

IRK_C; Inward rectifier potassium channel C-terminal domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_020269.3: Suppressed sequence

Description

NM_020269.3: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.