F11r F11 receptor [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: F11rprovided by MGI
Official Full Name: F11 receptorprovided by MGI
Primary source: MGI:1321398
See related: Ensembl:ENSMUSG00000038235; Vega:OTTMUSG00000021724
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: JAM; Jcam; JAM-1; JAM-A; Jcam1; Ly106; ESTM33; AA638916; 9130004G24

Genomic context

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Location :: 1 H2; 1 79.43 cM

Sequence :: Chromosome: 1; NC_000067.6 (171437561..171464593)

See F11r in Epigenomics, MapViewer

Chromosome 1 - NC_000067.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

The crucial role of JAM-A in the transmigration of neutrophils from the vasculature into inflamed tissues.
Title: Effects of JAM-A deficiency or blocking antibodies on neutrophil migration and lung injury in a murine model of ALI.
The chemokine (C-C motif) ligand 2 (CCL2) induced JAM-A redistribution from the interendothelial cell area to the apical surface of brain endothelial cells.
Title: Relocalization of junctional adhesion molecule A during inflammatory stimulation of brain endothelial cells.
CASK negatively regulates PMCA4b by directly binding to it and JAM-A positively regulates it indirectly through CASK
Title: CASK interacts with PMCA4b and JAM-A on the mouse sperm flagellum to regulate Ca2+ homeostasis and motility.
JAM-A normally limits platelet accumulation by inhibiting integrin outside-in signaling thus preventing premature platelet activation.
Title: JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in platelets.
Data suggest that aPKC phosphorylates JAM-A at S285 to regulate cell-cell contact maturation, TJ formation, and single lumen specification.
Title: aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation.
downregulation of JAM-A reduces tumor aggressive behavior by increasing cell susceptibility to apoptosis
Title: Abrogation of junctional adhesion molecule-A expression induces cell apoptosis and reduces breast cancer progression.
Data demenstrate that JAM-A restricts intestinal epithelial cell (IEC) proliferation in a dimerization-dependent manner, by inhibiting Akt-dependent beta-catenin activation.
Title: JAM-A regulates epithelial proliferation through Akt/β-catenin signalling.
Our data show that JAM-A is a novel surface marker for NG2-glia cells of the adult brain.
Title: JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain.
In the Rip1Tag2 tumor model, abrogation of JAM-A reduces cancer development by increasing antitumor immune response.
Title: Inactivation of junctional adhesion molecule-A enhances antitumoral immune response by promoting dendritic cell and T lymphocyte infiltration.
JAM-A dimerization facilitates formation of a complex with Afadin and PDZ-GEF2 that activates Rap1A, which regulates beta1 integrin levels and cell migration.
Title: Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration.

Submit: New GeneRIF Correction See all (27)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (1) 1 citation
Gene trapped (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_766235.1	NP_034950.1	Mpdz	BIND	PubMed	F11r (JAM) interacts with Mpdz (MUPP1). This interaction was modeled on a demonstrated interaction between F11r (JAM) from an unspecified species and mouse Mpdz (MUPP1).
BioGRID:200861	BioGRID:114141	CASK	BioGRID	PubMed	Affinity Capture-Western
BioGRID:200861	BioGRID:201476	Mpdz	BioGRID	PubMed	Reconstituted Complex

Pathways from BioSystems

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Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
Cell junction organization, organism-specific biosystem (from REACTOME)
Cell junction organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
Cell surface interactions at the vascular wall, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell-Cell communication, organism-specific biosystem (from REACTOME)
Cell-Cell communication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell-cell junction organization, organism-specific biosystem (from REACTOME)
Cell-cell junction organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
Integrin cell surface interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
Leukocyte transendothelial migration, conserved biosystem (from KEGG)
Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by TGF-beta Receptor Complex, organism-specific biosystem (from REACTOME)
Signaling by TGF-beta Receptor Complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), organism-specific biosystem (from REACTOME)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Tight junction, organism-specific biosystem (from KEGG)
Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
Tight junction, conserved biosystem (from KEGG)
Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
Tight junction interactions, organism-specific biosystem (from REACTOME)
Tight junction interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

General gene information

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Markers

F11r (e-PCR), detects polymorphism
- UniSTS:516175

AA638916 (e-PCR), detects polymorphism
- UniSTS:143019

F11r (e-PCR), detects polymorphism
- UniSTS:525484

F11r (e-PCR), detects polymorphism
- UniSTS:536568

F11r (e-PCR), detects polymorphism
- UniSTS:536569

Homology

Homologs of the F11r gene: The F11r gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cell adhesion	IDA Inferred from Direct Assay more info	PubMed
epithelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
virus-host interaction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell junction	IEA Inferred from Electronic Annotation more info
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	ISO Inferred from Sequence Orthology more info
tight junction	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: junctional adhesion molecule A

Names: junctional adhesion molecule A; BV11 antigen; F11 receptor/F11R; junctional adhesion molecule 1; junction cell adhesion molecule1; junction cell adhesion molecule A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172647.2 → NP_766235.1 junctional adhesion molecule A precursor

Status: VALIDATED

Source sequence(s)

AK033574, CJ317566

Consensus CDS

CCDS15496.1

UniProtKB/Swiss-Prot

O88792

Related

ENSMUSP00000041907, OTTMUSP00000024286, ENSMUST00000043839, OTTMUST00000051546

Conserved Domains (2) summary

cd00096
Location:148 – 224
Blast Score: 119

Ig; Immunoglobulin domain

pfam07679
Location:35 – 127
Blast Score: 128

I-set; Immunoglobulin I-set domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000067.6 Reference GRCm38.p1 C57BL/6J

Range

171437561..171464593

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000023.1 Alternate Mm_Celera

Range

173888870..173917464

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01001508.1	None
genomic	AAHY01001509.1	None
genomic	AAHY01001510.1	None
genomic	AAHY01001511.1	None
genomic	AAHY01001512.1 (7391..9661)	None
genomic	AC087229.27 (182932..209964)	None	C57BL/6J
genomic	CH466520.2	EDL39078.1	mixed
mRNA	AK033574.1	BAC28369.1	C57BL/6J
mRNA	BC021876.1	AAH21876.1
mRNA	CJ317566.1	None
mRNA	CT010347.1	CAJ18555.1