Jak3 Janus kinase 3 [Mus musculus] - Gene

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Summary

Official Symbol: Jak3provided by MGI
Official Full Name: Janus kinase 3provided by MGI
Primary source: MGI:99928
See related: Ensembl:ENSMUSG00000031805; Vega:OTTMUSG00000021111
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: fae; wil

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Genomic context

Location :: 8 B3.3; 8 33.0 cM

Sequence :: Chromosome: 8; NC_000074.6 (71676383..71690577)

See Jak3 in Epigenomics, MapViewer

Chromosome 8 - NC_000074.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

JAK3 inhibition potently facilitates myoblast differentiation through antagonistic STAT1/STAT3 activities.
Title: Role of JAK3 in myogenic differentiation.
dominant-negative mutants of either Cullin1 or Cullin5, which lack the C terminus responsible for recruiting the E2 enzymes, were able to prevent JAK3 degradation induced by both ASB2/SKP2 and NOTCH signaling.
Title: A mechanism underlying NOTCH-induced and ubiquitin-mediated JAK3 degradation.
This study defines a novel JAK3 mutation among patients with N-DS AML and demonstrates that normal individuals can also display germline JAK3 substitutions, previously proven to have oncogenic properties, in vitro and in vivo.
Title: Description of a novel Janus kinase 3 P132A mutation in acute megakaryoblastic leukemia and demonstration of previously reported Janus kinase 3 mutations in normal subjects.
Janus kinase 3 is expressed in erythrocytes, phosphorylated upon energy depletion and involved in the regulation of suicidal erythrocyte death.
Title: Janus kinase 3 is expressed in erythrocytes, phosphorylated upon energy depletion and involved in the regulation of suicidal erythrocyte death.
Human cord blood-derived CD34+ hematopoietic stem cells were successfully engrafted into Balb/c Rag-2-/-Jak3-/- mice; however, the engraftment rate was far lower in C57/BL6 Rag-2-/-Jak3-/- mice.
Title: Comparative study of human hematopoietic cell engraftment into BALB/c and C57BL/6 strain of rag-2/jak3 double-deficient mice.
Jak3 inhibition induced neuronal differentiation accompanied by neurite growth.
Title: Differential regulation of proliferation and differentiation in neural precursor cells by the Jak pathway.
the CD69 cytoplasmic tail associates with the Jak3/Stat5 signaling pathway, which regulates the transcription of RORgammat and, consequently, differentiation toward the Th17 lineage
Title: CD69 association with Jak3/Stat5 proteins regulates Th17 cell differentiation.
despite its dependence on leukemia inhibitory factor, JAK3 is not essential for LIF-mediated photoreceptor protection or gene expression.
Title: LIF-dependent JAK3 activation is not essential for retinal degeneration.
Jak3 is important for dendritic cell maturation, migration and function, through a CCR7-mediated signalling pathway
Title: Jak3 is involved in dendritic cell maturation and CCR7-dependent migration.
functions of JAK3 in the development of skin immune responses and diseases such as psoriasis
Title: JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 mutant PL/J mice.

Submit: New GeneRIF Correction See all (24)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (knock-out) (4) 1 citation
Chemically induced (ENU) (2)

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_034719.2	NP_034719.2	Jak3	BIND	PubMed	JAK3 autophosphorylates JAK3.
BioGRID:200858	BioGRID:119674	ASB2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:200858	BioGRID:112393	SKP2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:200858	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
kinase activity	IEA Inferred from Electronic Annotation more info
non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase activity	IEA Inferred from Electronic Annotation more info
protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
transferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
T cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
elevation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
enzyme linked receptor protein signaling pathway	IDA Inferred from Direct Assay more info	PubMed
innate immune response	IEA Inferred from Electronic Annotation more info
intracellular protein kinase cascade	IDA Inferred from Direct Assay more info	PubMed
lymph node development	TAS Traceable Author Statement more info	PubMed
negative regulation of FasL biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of T-helper 1 cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of dendritic cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of thymocyte apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of anti-apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
positive regulation of immune response	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
protein autophosphorylation	ISO Inferred from Sequence Orthology more info
protein phosphorylation	IEA Inferred from Electronic Annotation more info
regulation of T cell apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
response to interleukin-15	TAS Traceable Author Statement more info	PubMed
response to interleukin-2	TAS Traceable Author Statement more info	PubMed
response to interleukin-4	ISO Inferred from Sequence Orthology more info
response to interleukin-4	TAS Traceable Author Statement more info	PubMed
response to interleukin-9	TAS Traceable Author Statement more info	PubMed
tyrosine phosphorylation of Stat5 protein	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
cytoplasm	ISO Inferred from Sequence Orthology more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
intracellular	IC Inferred by Curator more info	PubMed
intracellular	IDA Inferred from Direct Assay more info	PubMed
membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: tyrosine-protein kinase JAK3

Names: tyrosine-protein kinase JAK3

NP_001177759.1

EC 2.7.10.2

NP_034719.2

EC 2.7.10.2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190830.1 → NP_001177759.1 tyrosine-protein kinase JAK3

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC162033, AK164520

UniProtKB/Swiss-Prot

Q62137

Conserved Domains (4) summary

smart00295
Location:42 – 200
Blast Score: 222

B41; Band 4.1 homologues

pfam07714
Location:818 – 1091
Blast Score: 788

Pkinase_Tyr; Protein tyrosine kinase

cl15255
Location:359 – 455
Blast Score: 385

SH2; Src homology 2 (SH2) domain

cl09925
Location:813 – 1095
Blast Score: 1272

PKc_like; Protein Kinases, catalytic domain
NM_010589.6 → NP_034719.2 tyrosine-protein kinase JAK3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and shares its terminal exon with the insulin-like 3 gene(GeneID:16336). Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC162033, AK038268, AW456897

Consensus CDS

CCDS22403.1

UniProtKB/Swiss-Prot

Q62137

Related

ENSMUSP00000060073, OTTMUSP00000023247, ENSMUST00000051995, OTTMUST00000049960

Conserved Domains (4) summary

smart00295
Location:42 – 200
Blast Score: 222

B41; Band 4.1 homologues

pfam07714
Location:818 – 1091
Blast Score: 788

Pkinase_Tyr; Protein tyrosine kinase

cl15255
Location:359 – 455
Blast Score: 385

SH2; Src homology 2 (SH2) domain

cl09925
Location:813 – 1095
Blast Score: 1272

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000074.6 Reference GRCm38 C57BL/6J

Range

71676383..71690577

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000030.1 Alternate Mm_Celera

Range

74190947..74205123

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC162033.11 (131898..143915)	None
genomic	U71201.2	AAB40917.2	129/J
mRNA	AK038268.1	BAC29956.1	C57BL/6J
mRNA	AK088365.1	BAC40305.1	NOD
mRNA	AK142178.1	BAE24964.1	C57BL/6J
mRNA	AK156646.1	BAE33790.1	NOD
mRNA	AK164520.1	BAE37819.1	C57BL/6J
mRNA	AW456897.1	None	C57BL/6J
mRNA	BC027234.1	None
mRNA	BC105577.1	AAI05578.1	FVB/N
mRNA	BC131646.1	AAI31647.1
mRNA	BC131647.1	AAI31648.1
mRNA	L32955.1	AAA21565.1	BALB/c
mRNA	L33768.1	AAA21415.1
mRNA	L40172.1	AAC42085.1	BALB/c x 129 F2