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Jak2 Janus kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 16452, updated on 28-May-2016
Official Symbol
Jak2provided by MGI
Official Full Name
Janus kinase 2provided by MGI
Primary source
MGI:MGI:96629
See related
Ensembl:ENSMUSG00000024789
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fd17
Orthologs
Location:
19 C1; 19 23.73 cM
Exon count:
28
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 19 NC_000085.6 (29251776..29313080)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (29326318..29387570)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene predicted gene 5518 Neighboring gene predicted gene, 41829 Neighboring gene insulin-like 6 Neighboring gene relaxin 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
acetylcholine receptor binding ISO
Inferred from Sequence Orthology
more info
 
growth hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
growth hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
heme binding ISO
Inferred from Sequence Orthology
more info
 
histone binding ISO
Inferred from Sequence Orthology
more info
 
histone kinase activity (H3-Y41 specific) IBA
Inferred from Biological aspect of Ancestor
more info
 
histone kinase activity (H3-Y41 specific) ISO
Inferred from Sequence Orthology
more info
 
insulin receptor substrate binding ISO
Inferred from Sequence Orthology
more info
 
interleukin-12 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
peptide hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
type 1 angiotensin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
JAK-STAT cascade IDA
Inferred from Direct Assay
more info
PubMed 
JAK-STAT cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
 
JAK-STAT cascade involved in growth hormone signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
JAK-STAT cascade involved in growth hormone signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
JAK-STAT cascade involved in growth hormone signaling pathway ISO
Inferred from Sequence Orthology
more info
 
STAT protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
activation of JAK2 kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of MAPKK activity ISO
Inferred from Sequence Orthology
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
axon regeneration ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular response to dexamethasone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to interleukin-3 IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
chromatin modification IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
enzyme linked receptor protein signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
growth hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
histone H3-Y41 phosphorylation ISO
Inferred from Sequence Orthology
more info
 
hormone-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
host programmed cell death induced by symbiont IDA
Inferred from Direct Assay
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
interferon-gamma-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
interleukin-12-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
mammary gland epithelium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mineralocorticoid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of growth hormone receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric-oxide synthase biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein import into nucleus, translocation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tyrosine phosphorylation of Stat3 protein IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tyrosine phosphorylation of Stat5 protein IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vascular smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
post-embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
response to antibiotic ISO
Inferred from Sequence Orthology
more info
PubMed 
response to granulocyte macrophage colony-stimulating factor NAS
Non-traceable Author Statement
more info
PubMed 
response to hydroperoxide ISO
Inferred from Sequence Orthology
more info
 
response to interleukin-12 ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
tyrosine phosphorylation of Stat1 protein ISO
Inferred from Sequence Orthology
more info
 
tyrosine phosphorylation of Stat3 protein ISO
Inferred from Sequence Orthology
more info
 
tyrosine phosphorylation of Stat5 protein ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
caveola IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
tyrosine-protein kinase JAK2
Names
JAK-2
NP_001041642.1
NP_032439.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048177.2NP_001041642.1  tyrosine-protein kinase JAK2

    See identical proteins and their annotated locations for NP_001041642.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC119228, AK087255, BC054807, BE981299, BF019856, BG068603, CD363707, CJ046359
    Consensus CDS
    CCDS37950.1
    UniProtKB/Swiss-Prot
    Q62120
    UniProtKB/TrEMBL
    G5E852
    Related
    ENSMUSP00000025705, ENSMUST00000025705
    Conserved Domains (6) summary
    cd10379
    Location:386482
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:38270
    B41; Band 4.1 homologues
    pfam07714
    Location:8491119
    Pkinase_Tyr; Protein tyrosine kinase
    cd13333
    Location:266386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:545806
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:8441127
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
  2. NM_008413.3NP_032439.2  tyrosine-protein kinase JAK2

    See identical proteins and their annotated locations for NP_032439.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC119228, AK087255, BC054807, BE981299, BF019856, BG068603, CD363707, CJ046359
    Consensus CDS
    CCDS37950.1
    UniProtKB/Swiss-Prot
    Q62120
    UniProtKB/TrEMBL
    G5E852
    Related
    ENSMUSP00000064394, ENSMUST00000065796
    Conserved Domains (6) summary
    cd10379
    Location:386482
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:38270
    B41; Band 4.1 homologues
    pfam07714
    Location:8491119
    Pkinase_Tyr; Protein tyrosine kinase
    cd13333
    Location:266386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:545806
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:8441127
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p3 C57BL/6J

    Range
    29251776..29313080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526715.2XP_006526778.1  

    Conserved Domains (5) summary
    cd10379
    Location:386482
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:38270
    B41; Band 4.1 homologues
    cd13333
    Location:266386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd14473
    Location:152261
    FERM_B-lobe; FERM domain B-lobe
    cl21453
    Location:545592
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006526713.2XP_006526776.1  

    Conserved Domains (6) summary
    cd10379
    Location:386482
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:38270
    B41; Band 4.1 homologues
    pfam07714
    Location:8041074
    Pkinase_Tyr; Protein tyrosine kinase
    cd13333
    Location:266386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd14205
    Location:7991082
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cl21453
    Location:548761
    PKc_like; Protein Kinases, catalytic domain
  3. XM_011247155.1XP_011245457.1  

    See identical proteins and their annotated locations for XP_011245457.1

    UniProtKB/TrEMBL
    G5E852
    Conserved Domains (6) summary
    cd10379
    Location:386482
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:38270
    B41; Band 4.1 homologues
    pfam07714
    Location:8491119
    Pkinase_Tyr; Protein tyrosine kinase
    cd13333
    Location:266386
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:545806
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:8441127
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
  4. XM_006526714.2XP_006526777.1  

    Conserved Domains (5) summary
    cd10379
    Location:190286
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    pfam07714
    Location:653923
    Pkinase_Tyr; Protein tyrosine kinase
    cd13333
    Location:70190
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:349610
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:648931
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

Alternate Mm_Celera

Genomic

  1. AC_000041.1 Alternate Mm_Celera

    Range
    30028576..30089642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)