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Jak1 Janus kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 16451, updated on 28-May-2016
Official Symbol
Jak1provided by MGI
Official Full Name
Janus kinase 1provided by MGI
Primary source
MGI:MGI:96628
See related
Ensembl:ENSMUSG00000028530 Vega:OTTMUSG00000008208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BAP004; AA960307; C130039L05Rik
Orthologs
Location:
4 C6; 4 46.19 cM
Exon count:
27
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (101151974..101265297, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (100824579..100937887, complement)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene cache domain containing 1 Neighboring gene predicted gene, 35956 Neighboring gene ribonucleoprotein, PTB-binding 2 Neighboring gene proteasome (prosome, macropain) subunit, beta type 2 pseudogene Neighboring gene RIKEN cDNA E130102H24 gene Neighboring gene RIKEN cDNA 0610043K17 gene Neighboring gene ribosomal protein L9 pseudogene Neighboring gene microRNA 101a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC37919

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
CCR5 chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
growth hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
growth hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular response to interleukin-3 IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
enzyme linked receptor protein signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
interleukin-2-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
response to antibiotic ISO
Inferred from Sequence Orthology
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
tyrosine-protein kinase JAK1
Names
JAK-1
NP_666257.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146145.2NP_666257.2  tyrosine-protein kinase JAK1

    See identical proteins and their annotated locations for NP_666257.2

    Status: VALIDATED

    Source sequence(s)
    AK141210, AK152128, AL627251, AL645668
    Consensus CDS
    CCDS18393.1
    UniProtKB/TrEMBL
    B1ASP2, Q3U8P8, Q3URU8
    Related
    ENSMUSP00000099842, OTTMUSP00000008566, ENSMUST00000102781, OTTMUST00000018649
    Conserved Domains (6) summary
    cd05079
    Location:8691152
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd10378
    Location:426526
    SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins
    smart00295
    Location:37286
    B41; Band 4.1 homologues
    pfam07714
    Location:8741146
    Pkinase_Tyr; Protein tyrosine kinase
    cd05077
    Location:582845
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    101151974..101265297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502812.2XP_006502875.1  

    See identical proteins and their annotated locations for XP_006502875.1

    UniProtKB/TrEMBL
    B1ASP2
    Conserved Domains (6) summary
    cd05079
    Location:8691152
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd10378
    Location:426526
    SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins
    smart00295
    Location:37286
    B41; Band 4.1 homologues
    pfam07714
    Location:8741146
    Pkinase_Tyr; Protein tyrosine kinase
    cd05077
    Location:582845
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1
  2. XM_011240451.1XP_011238753.1  

    See identical proteins and their annotated locations for XP_011238753.1

    UniProtKB/TrEMBL
    B1ASP2
    Conserved Domains (6) summary
    cd05079
    Location:8691152
    PTKc_Jak1_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd10378
    Location:426526
    SH2_Jak1; Src homology 2 (SH2) domain in the Janus kinase 1 (Jak1) proteins
    smart00295
    Location:37286
    B41; Band 4.1 homologues
    pfam07714
    Location:8741146
    Pkinase_Tyr; Protein tyrosine kinase
    cd05077
    Location:582845
    PTK_Jak1_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
    cd13332
    Location:282426
    FERM_C_JAK1; FERM domain C-lobe of Janus kinase 1

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    99494673..99536518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)