Itpr2 inositol 1,4,5-triphosphate receptor 2 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Itpr2provided by MGI
Official Full Name: inositol 1,4,5-triphosphate receptor 2provided by MGI
Primary source: MGI:99418
Locus tag: CH25-20L19.1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ip3r2; Itpr5; insP3R2; AI649341; InsP3R-2; InsP3R-5

Genomic context

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Location :: 6 G3; 6 77.7 cM

Sequence :: Chromosome: 6; NC_000072.6 (146111480..146501912, complement)

See Itpr2 in Epigenomics, MapViewer

Chromosome 6 - NC_000072.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

IP3R-deficient acinar cells accumulate zymogen granules, but the mice do not succumb to pancreatic damage or worse pancreatitis outcomes.
Title: IP3 receptor type 2 deficiency is associated with a secretory defect in the pancreatic acinar cell and an accumulation of zymogen granules.
Conclude that IP3-R(2) do not contribute to the progression of dilated cardiomyopathy or pressure overload hypertrophy, despite increased expression and heightened generation of the ligand, Ins(1,4,5)P3.
Title: No contribution of IP3-R(2) to disease phenotype in models of dilated cardiomyopathy or pressure overload hypertrophy.
Results suggest that type 2 IP(3)R is the major functional IP(3)R subtype involved in agonist-induced Ca(2+) release in Bergmann glia
Title: Type 2 inositol 1,4,5-trisphosphate receptor is predominantly involved in agonist-induced Ca(2+) signaling in Bergmann glia.
serine 150 of the InsP(3)R2 is phosphorylated by CaMKII and results in a decrease in the channel open probability.
Title: Modulation of inositol 1,4,5-trisphosphate receptor type 2 channel activity by Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation.
The IP(3)RII-induced calcium release (IICR) initiated the hypertrophy-associated decrease in miR-133a.
Title: Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy.
These findings indicate that an mGluR/IP(3)R2/cPLA(2)alpha signaling cascade in astrocytes is required to transduce neuronal glutamate release into arteriole responses.
Title: Astrocyte inositol triphosphate receptor type 2 and cytosolic phospholipase A2 alpha regulate arteriole responses in mouse neocortical brain slices.
Calcium dysregulation induced by oxidative stress upregulates type 2 inositol-1,4,5,-trisphophate receptors, showing relevance for subcellular calcium signaling and development of novel neuroprotective strategies in neurodegenerative disorders.
Title: Novel mechanism of increased Ca2+ release following oxidative stress in neuronal cells involves type 2 inositol-1,4,5-trisphosphate receptors.
This study demonistrated that Itpr2 regulate the plasticity of cerebral cortex in mice.
Title: Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivo.
Gene knock-outs of ITPR1 and ITPR2 result in perturbation of cardiogenesis.
Title: Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis.
IP(3)-mediated Ca(2+) release plays a central role in regulating cardiac hypertrophy downstream of IP3R2 signaling, in part, through a calcineurin-dependent mechanism.
Title: The IP3 receptor regulates cardiac hypertrophy in response to select stimuli.

Submit: New GeneRIF Correction See all (25)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (2) 1 citation

Pathways from BioSystems

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Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Alzheimer's disease, organism-specific biosystem (from KEGG)
Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
Alzheimer's disease, conserved biosystem (from KEGG)
Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystem (from REACTOME)
Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystemcomputationally inferred pathway (not manually curated)
B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ???? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation...
Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
Calcium signaling pathway, organism-specific biosystem (from KEGG)
Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
Calcium signaling pathway, conserved biosystem (from KEGG)
Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
Cholinergic synapse, organism-specific biosystem (from KEGG)
Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
DAG and IP3 signaling, organism-specific biosystem (from REACTOME)
DAG and IP3 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DAP12 interactions, organism-specific biosystem (from REACTOME)
DAP12 interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DAP12 signaling, organism-specific biosystem (from REACTOME)
DAP12 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Disease, organism-specific biosystem (from REACTOME)
Disease, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dopaminergic synapse, organism-specific biosystem (from KEGG)
Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
Dopaminergic synapse, conserved biosystem (from KEGG)
Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
Downstream signal transduction, organism-specific biosystem (from REACTOME)
Downstream signal transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signaling of activated FGFR, organism-specific biosystem (from REACTOME)
Downstream signaling of activated FGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
EGFR interacts with phospholipase C-gamma, organism-specific biosystem (from REACTOME)
EGFR interacts with phospholipase C-gamma, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Effects of PIP2 hydrolysis, organism-specific biosystem (from REACTOME)
Effects of PIP2 hydrolysis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Elevation of cytosolic Ca2+ levels, organism-specific biosystem (from REACTOME)
Elevation of cytosolic Ca2+ levels, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Estrogen signaling pathway, organism-specific biosystem (from KEGG)
Estrogen signaling pathway, organism-specific biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
Estrogen signaling pathway, conserved biosystem (from KEGG)
Estrogen signaling pathway, conserved biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
G alpha (q) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G-protein mediated events, organism-specific biosystem (from REACTOME)
G-protein mediated events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gap junction, organism-specific biosystem (from KEGG)
Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
Gap junction, conserved biosystem (from KEGG)
Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
Gastric acid secretion, organism-specific biosystem (from KEGG)
Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
Gastric acid secretion, conserved biosystem (from KEGG)
Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glutamatergic synapse, organism-specific biosystem (from KEGG)
Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
Glutamatergic synapse, conserved biosystem (from KEGG)
Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
GnRH signaling pathway, organism-specific biosystem (from KEGG)
GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
GnRH signaling pathway, conserved biosystem (from KEGG)
GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Integration of energy metabolism, organism-specific biosystem (from REACTOME)
Integration of energy metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Long-term depression, organism-specific biosystem (from KEGG)
Long-term depression, organism-specific biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
Long-term depression, conserved biosystem (from KEGG)
Long-term depression, conserved biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
Long-term potentiation, organism-specific biosystem (from KEGG)
Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
Long-term potentiation, conserved biosystem (from KEGG)
Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
Myometrial Relaxation and Contraction Pathways, organism-specific biosystem
Myometrial Relaxation and Contraction Pathways
NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
NGF signalling via TRKA from the plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Oocyte meiosis, organism-specific biosystem (from KEGG)
Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
Oocyte meiosis, conserved biosystem (from KEGG)
Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
Opioid Signalling, organism-specific biosystem (from REACTOME)
Opioid Signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PLC beta mediated events, organism-specific biosystem (from REACTOME)
PLC beta mediated events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PLC-gamma1 signalling, organism-specific biosystem (from REACTOME)
PLC-gamma1 signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PLCG1 events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
PLCG1 events in ERBB2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pancreatic secretion, organism-specific biosystem (from KEGG)
Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
Pancreatic secretion, conserved biosystem (from KEGG)
Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
Phosphatidylinositol signaling system, organism-specific biosystem (from KEGG)
Phosphatidylinositol signaling system, organism-specific biosystem
Phosphatidylinositol signaling system
Phosphatidylinositol signaling system, conserved biosystem (from KEGG)
Phosphatidylinositol signaling system, conserved biosystem
Phosphatidylinositol signaling system
Phospholipase C-mediated cascade, organism-specific biosystem (from REACTOME)
Phospholipase C-mediated cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Platelet calcium homeostasis, organism-specific biosystem (from REACTOME)
Platelet calcium homeostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Platelet homeostasis, organism-specific biosystem (from REACTOME)
Platelet homeostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Regulation of Insulin Secretion, organism-specific biosystem (from REACTOME)
Regulation of Insulin Secretion, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Insulin Secretion by Glucagon-like Peptide-1, organism-specific biosystem (from REACTOME)
Regulation of Insulin Secretion by Glucagon-like Peptide-1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Retrograde endocannabinoid signaling, organism-specific biosystem (from KEGG)
Retrograde endocannabinoid signaling, organism-specific biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
Retrograde endocannabinoid signaling, conserved biosystem (from KEGG)
Retrograde endocannabinoid signaling, conserved biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
Role of phospholipids in phagocytosis, organism-specific biosystem (from REACTOME)
Role of phospholipids in phagocytosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Salivary secretion, organism-specific biosystem (from KEGG)
Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
Salivary secretion, conserved biosystem (from KEGG)
Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
Serotonergic synapse, organism-specific biosystem (from KEGG)
Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR, organism-specific biosystem (from REACTOME)
Signaling by EGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
Signaling by EGFR in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by ERBB2, organism-specific biosystem (from REACTOME)
Signaling by ERBB2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR, organism-specific biosystem (from REACTOME)
Signaling by FGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
Signaling by FGFR in disease, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by PDGF, organism-specific biosystem (from REACTOME)
Signaling by PDGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
Signaling by the B Cell Receptor (BCR), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signalling by NGF, organism-specific biosystem (from REACTOME)
Signalling by NGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
Vascular smooth muscle contraction, conserved biosystem (from KEGG)
Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...

General gene information

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Markers

35.MMHAP94FLD5.seq (e-PCR)
- UniSTS:124164

D6Mit294 (e-PCR), detects polymorphism
- UniSTS:130844

D4M6Mit295 (e-PCR)
- UniSTS:130845

D6Mit295 (e-PCR), detects polymorphism
- UniSTS:130845

AI649341 (e-PCR)
- UniSTS:179496

Z71173 (e-PCR)
- UniSTS:163405

14.MMHAP57FLE2.seq (e-PCR)
- UniSTS:123218

Sspn (e-PCR), detects polymorphism
- UniSTS:143724

D6Mit15 (e-PCR), detects polymorphism
- UniSTS:116332

D6Mit371 (e-PCR), detects polymorphism
- UniSTS:130926

Y83m2c2 (e-PCR), detects polymorphism
- UniSTS:144805

BB062653 (e-PCR)
- UniSTS:208052

12.MMHAP34FLD3.seq (e-PCR)
- UniSTS:123115

MHAa52a5.seq (e-PCR)
- UniSTS:125182

Homology

Homologs of the Itpr2 gene: The Itpr2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and chicken.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
calcium channel activity	IEA Inferred from Electronic Annotation more info
calcium ion binding	ISO Inferred from Sequence Orthology more info
calcium-release channel activity	IDA Inferred from Direct Assay more info	PubMed
inositol 1,4,5 trisphosphate binding	ISO Inferred from Sequence Orthology more info
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IDA Inferred from Direct Assay more info	PubMed
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	ISO Inferred from Sequence Orthology more info
ion channel activity	IEA Inferred from Electronic Annotation more info
phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
cellular response to cAMP	IDA Inferred from Direct Assay more info
cellular response to ethanol	IMP Inferred from Mutant Phenotype more info
inositol phosphate-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
inositol phosphate-mediated signaling	ISO Inferred from Sequence Orthology more info
ion transport	IEA Inferred from Electronic Annotation more info
response to hypoxia	ISO Inferred from Sequence Orthology more info
transmembrane transport	IEA Inferred from Electronic Annotation more info
transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
axon	ISO Inferred from Sequence Orthology more info
cell cortex	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
myelin sheath	ISO Inferred from Sequence Orthology more info
plasma membrane	ISO Inferred from Sequence Orthology more info
sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inositol 1,4,5-trisphosphate receptor type 2

Names: inositol 1,4,5-trisphosphate receptor type 2; IP3R 2; IP3 receptor; type 2 InsP3 receptor; inositol 1,4,5-triphosphate receptor 5; inositol trisphosphate receptor type 2; inositol 1,4,5-trisphosphate type V receptor; type 2 inositol 1,4,5-trisphosphate receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010586.2 → NP_034716.1 inositol 1,4,5-trisphosphate receptor type 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks one exon in the coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.

Source sequence(s)

AB182290, AK028484, AK046210, AK143206, AW049374

Consensus CDS

CCDS39708.1

UniProtKB/TrEMBL

Q8CED6

UniProtKB/Swiss-Prot

Q9Z329

Conserved Domains (5) summary

pfam08454
Location:1882 – 1975
Blast Score: 326

RIH_assoc; RyR and IP3R Homology associated

smart00472
Location:261 – 291
Blast Score: 103

MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases

pfam01365
Location:438 – 641
Blast Score: 658

RYDR_ITPR; RIH domain

pfam02815
Location:199 – 399
Blast Score: 601

MIR; MIR domain

pfam08709
Location:4 – 192
Blast Score: 621

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_019923.4 → NP_064307.2 inositol 1,4,5-trisphosphate receptor type 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AB182288, AK028484, AK046210, AK143206, AW049374

Consensus CDS

CCDS39709.1

UniProtKB/TrEMBL

Q8CED6

UniProtKB/Swiss-Prot

Q9Z329

Conserved Domains (5) summary

pfam08454
Location:1915 – 2008
Blast Score: 326

RIH_assoc; RyR and IP3R Homology associated

smart00472
Location:294 – 324
Blast Score: 103

MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases

pfam01365
Location:471 – 674
Blast Score: 658

RYDR_ITPR; RIH domain

pfam02815
Location:232 – 432
Blast Score: 601

MIR; MIR domain

pfam08709
Location:4 – 225
Blast Score: 801

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000072.6 Reference GRCm38.p1 C57BL/6J

Range

146111480..146501912, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p1 NOD/ShiLtJ

Genomic

NT_166305.2 Reference GRCm38.p1 NOD/ShiLtJ

Range

2612685..3014124, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000028.1 Alternate Mm_Celera

Range

149142524..149540657, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01058969.1 (5758..30347)	None
genomic	AAHY01058970.1	None
genomic	AAHY01058971.1	None
genomic	AAHY01058972.1	None
genomic	AAHY01058973.1	None
genomic	AAHY01058974.1	None
genomic	AAHY01058975.1	None
genomic	AAHY01058976.1	None
genomic	AAHY01058977.1	None
genomic	AAHY01058978.1	None
genomic	AAHY01058979.1	None
genomic	AAHY01058980.1	None
genomic	AAHY01058981.1	None
genomic	AAHY01058982.1	None
genomic	AAHY01058983.1	None
genomic	AAHY01058984.1	None
genomic	AAHY01058985.1	None
genomic	AAHY01058986.1	None
genomic	AAHY01058987.1	None
genomic	AAHY01058988.1	None
genomic	AAHY01058989.1	None
genomic	AAHY01058990.1	None
genomic	AAHY01058991.1	None
genomic	AAHY01058992.1	None
genomic	AAHY01058993.1	None
genomic	AAHY01058994.1	None
genomic	AAHY01058995.1	None
genomic	AAHY01058996.1	None
genomic	AC129573.16 (50596..137983)	None
genomic	AC153574.4	None
genomic	AC155836.5 (118286..147664)	None
genomic	AC158648.2 (79612..205189)	None
genomic	AC174928.2 (41472..94653)	None
genomic	AF031127.1	AAC04327.1	C3H
genomic	CH466572.1	EDL10703.1	mixed
genomic	CU207302.23 (2013..210009)	None
genomic	CU207317.13 (2001..146619)	None
genomic	CU207333.11 (28781..77604)	None
mRNA	AB012393.1	BAA33960.1
mRNA	AB182288.1	BAD90682.1
mRNA	AB182290.1	BAD90684.1
mRNA	AK028484.1	BAC25975.1	C57BL/6J
mRNA	AK030915.1	BAC27181.2	C57BL/6J
mRNA	AK046210.1	None	C57BL/6J
mRNA	AK079983.1	BAC37799.1	C57BL/6J
mRNA	AK136257.1	BAE22899.1	C57BL/6J
mRNA	AK143206.1	None	C57BL/6J
mRNA	AK169446.1	None	C57BL/6J
mRNA	AW049374.1	None	C57BL/6J
mRNA	BB638298.1	None
mRNA	BC013815.1	None	FVB/N
mRNA	BC025805.1	AAH25805.1	CZECHII
mRNA	BC033315.1	None	CZECHII
mRNA	BC100369.1	AAI00370.1
mRNA	BY252197.1	None	C57BL/6J
mRNA	GU980658.1	ADG01867.1
mRNA	Z33908.1	CAA83957.1	C3H
mRNA	Z71173.1	CAA94861.1	C3H