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    Itgb5 integrin beta 5 [ Mus musculus (house mouse) ]

    Gene ID: 16419, updated on 11-May-2013
    Official Symbol
    Itgb5provided by MGI
    Official Full Name
    integrin beta 5provided by MGI
    Primary source
    MGI:96614
    See related
    Ensembl:ENSMUSG00000022817; Vega:OTTMUSG00000028487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    [b]5; [b]-5; [b]5A; [b]5B; beta5; ESTM23; beta-5; AA475909; AI874634
    Location :
    16 B3; 16
    Sequence :
    Chromosome: 16; NC_000082.6 (33829665..33949338)
    See Itgb5 in Epigenomics, MapViewer

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene HEG homolog 1 (zebrafish) Neighboring gene mucin 13, epithelial transmembrane Neighboring gene uridine monophosphate synthetase Neighboring gene kalirin, RhoGEF kinase Neighboring gene predicted gene 4581

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Saccharomyces boulardii improves intestinal epithelial cell restitution by inhibiting αvβ5 integrin activation state. Canonici A, et al. PLoS One, 2012. PMID 23028753.
    2. Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors. Metzakopian E, et al. Development, 2012 Jul. PMID 22696295.
    3. Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5-/- or Mfge8-/- mouse retina. Ruggiero L, et al. Proc Natl Acad Sci U S A, 2012 May 22. PMID 22566632.
    4. Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module. Koss M, et al. Dev Cell, 2012 May 15. PMID 22560297.
    5. Functional consequences of necdin nucleocytoplasmic localization. Lavi-Itzkovitz A, et al. PLoS One, 2012. PMID 22442722.

    See all (68) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Saccharomyces boulardii supernatant contains motogenic factors that enhance cell restitution through multiple pathways, including the dynamic fine regulation of alphavbeta5 integrin binding activity.
      Title: Saccharomyces boulardii improves intestinal epithelial cell restitution by inhibiting αvβ5 integrin activation state.
    2. Phosphatidylserine-marked tips do not vary in mice lacking the diurnal phagocytic rhythm of the retinal epithelium due to loss of either alphavbeta5 integrin, or its extracellular ligand milk fat globule-EGF factor 8.
      Title: Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5-/- or Mfge8-/- mouse retina.
    3. Data suggest that the alphavbeta3 and alphavbeta5 integrins are not essential for mediating microglial activation responses to vitronectin, but that microglia use multiple redundant receptors to mediate interactions with this ECM protein.
      Title: Microglia use multiple mechanisms to mediate interactions with vitronectin; non-essential roles for the highly-expressed αvβ3 and αvβ5 integrins.
    4. Absence of RG2 does not affect the retinal architecture that requires alphavbeta5 integrins.
      Title: αvβ5 integrin-dependent diurnal phagocytosis of shed photoreceptor outer segments by RPE cells is independent of the integrin coreceptor transglutaminase-2.
    5. The exclusive apical distribution of alphavbeta5 integrin receptors in the retinal pigment epithelium, is discussed.
      Title: Neural retina and MerTK-independent apical polarity of alphavbeta5 integrin receptors in the retinal pigment epithelium.
    6. Angiopoietin-like 4 interacts with integrins beta1 and beta5 to modulate keratinocyte migration.
      Title: Angiopoietin-like 4 interacts with integrins beta1 and beta5 to modulate keratinocyte migration.
    7. There is a critical role for the alphavbeta5/beta6 integrins in mediating the IL-1beta-induced acute lung injury.
      Title: Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms.
    8. Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway
      Title: Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway.
    9. microglia express alphavbeta3 & alphavbeta5 integrins; expression is independently regulated by cytokines & extracellular matrix proteins; alphavbeta5 integrin not essential for mediating microglial adhesion & MMP-9 expression in response to vitronectin
      Title: Microglial expression of alphavbeta3 and alphavbeta5 integrins is regulated by cytokines and the extracellular matrix: beta5 integrin null microglia show no defects in adhesion or MMP-9 expression on vitronectin.
    10. The active site within the Sdc1 core protein was identified and a peptide inhibitor called synstatin (SSTN) that disrupts Sdc1's interaction with alpha(v)beta(3) and alpha(v)beta(5) integrins was derived.
      Title: Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
    Submit: New GeneRIF Correction See all (21)
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (Floxed/Frt) (1) 
    • Targeted (knock-out) (1)  1 citation
    Products Interactant Other Gene Complex Source Pubs Description
    NP_034710.1 NP_032008.1 Ptk2    BIND  PubMed FAK interacts with integrin beta 5. 
    BioGRID:200832 BioGRID:204966 Mapk1    BioGRID  PubMed Affinity Capture-Western; Protein-peptide 
    BioGRID:200832 BioGRID:201712 Ndn    BioGRID  PubMed Two-hybrid 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    integrin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cell leading edge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    integrin beta-5
    Names
    integrin beta-5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145884.1 → NP_001139356.1  integrin beta-5 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.
      Source sequence(s)
      AF022110, BC058246, CJ316400
      Consensus CDS
      CCDS49835.1
      UniProtKB/Swiss-Prot
      O70309
      UniProtKB/TrEMBL
      Q6PE70
      Related
      ENSMUSP00000110680, OTTMUSP00000036002, ENSMUST00000115028, OTTMUST00000070600
      Conserved Domains (3) summary
      pfam07965
      Location:635 – 719
      Blast Score: 212
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:743 – 796
      Blast Score: 206
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      smart00187
      Location:35 – 463
      Blast Score: 1677
      INB; Integrin beta subunits (N-terminal portion of extracellular region)

    2. NM_010580.2 → NP_034710.2  integrin beta-5 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate coding exon compared to transcript variant 1. This results in a frame-shift, translation termination at a downstream stop codon, and a longer isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF022110, BC058246, CJ316400
      Consensus CDS
      CCDS28135.1
      UniProtKB/TrEMBL
      G5E8F8
      UniProtKB/Swiss-Prot
      O70309
      UniProtKB/TrEMBL
      Q6PE70
      Related
      ENSMUSP00000069416, OTTMUSP00000036003, ENSMUST00000069345, OTTMUST00000070601
      Conserved Domains (3) summary
      pfam07965
      Location:635 – 719
      Blast Score: 213
      Integrin_B_tail; Integrin beta tail domain
      pfam08725
      Location:743 – 759
      Blast Score: 102
      Integrin_b_cyt; Integrin beta cytoplasmic domain
      smart00187
      Location:35 – 463
      Blast Score: 1680
      INB; Integrin beta subunits (N-terminal portion of extracellular region)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p1 C57BL/6J

      Range
      33829665..33949338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000038.1 Alternate Mm_Celera

      Range
      34313798..34433456
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01126909.1 None
    genomic AAHY01126910.1 None
    genomic AAHY01126911.1 None
    genomic AAHY01126912.1 None
    genomic AAHY01126913.1 None
    genomic AAHY01126914.1 None
    genomic AAHY01126915.1 None
    genomic AAHY01126916.1 None
    genomic AAHY01126917.1 None
    genomic AAHY01126918.1 None
    genomic AAHY01126919.1 None
    genomic AAHY01126920.1 None
    genomic AAHY01126921.1 (1468..32077) None
    genomic AC155268.1 None
    genomic AC165079.2 (37514..63266) None
    genomic CH466521.1 EDK97855.1 mixed
      EDK97856.1 mixed
    mRNA AF022110.1 AAD08782.1
    mRNA AF043256.1 AAC40109.1
    mRNA AF043257.1 AAC40110.1
    mRNA AK087476.1 None C57BL/6J
    mRNA AK136315.1 None C57BL/6J
    mRNA AK140251.1 BAE24299.1 C57BL/6J
    mRNA AK143532.1 None C57BL/6J
    mRNA AK187695.1 None
    mRNA BC029170.1 None FVB/N
    mRNA BC046280.1 AAH46280.1 FVB/N
    mRNA BC058246.1 AAH58246.1
    mRNA CJ316400.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70309.2 GenPept UniProtKB/Swiss-Prot:O70309

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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