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DCK deoxycytidine kinase [ Homo sapiens (human) ]

Gene ID: 1633, updated on 26-May-2016
Official Symbol
DCKprovided by HGNC
Official Full Name
deoxycytidine kinaseprovided by HGNC
Primary source
HGNC:HGNC:2704
See related
Ensembl:ENSG00000156136 HPRD:00507; MIM:125450; Vega:OTTHUMG00000129908
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
Orthologs
Location:
4q13.3-q21.1
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (70993548..71030914)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71859265..71896631)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene G-rich RNA sequence binding factor 1 Neighboring gene MOB kinase activator 1B Neighboring gene uncharacterized LOC102724821 Neighboring gene solute carrier family 4 member 4 Neighboring gene lactate dehydrogenase A like 6E, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC117410, MGC138632

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
deoxycytidine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleoside kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
deoxyribonucleoside monophosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
purine-containing compound salvage TAS
Traceable Author Statement
more info
 
pyrimidine nucleoside salvage TAS
Traceable Author Statement
more info
 
pyrimidine nucleotide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
deoxycytidine kinase
Names
deoxynucleoside kinase
NP_000779.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023303.1 RefSeqGene

    Range
    5001..42367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000788.2NP_000779.1  deoxycytidine kinase

    See identical proteins and their annotated locations for NP_000779.1

    Status: REVIEWED

    Source sequence(s)
    BC103764, BI601939, CD014016
    Consensus CDS
    CCDS3548.1
    UniProtKB/Swiss-Prot
    P27707
    UniProtKB/TrEMBL
    F5CTF3
    Related
    ENSP00000286648, OTTHUMP00000160356, ENST00000286648, OTTHUMT00000252159
    Conserved Domains (2) summary
    COG1428
    Location:24260
    Dck; Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism]
    cd01673
    Location:23244
    dNK; Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1. ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    70993548..71030914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    71895140..71932501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)