Incenp inner centromere protein [Mus musculus] - Gene

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Summary

Official Symbol: Incenpprovided by MGI
Official Full Name: inner centromere proteinprovided by MGI
Primary source: MGI:1313288
See related: Ensembl:ENSMUSG00000024660
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C77457; AU019509; C130081E20; 2700067E22Rik

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Genomic context

Location :: 19 A; 19 0.0 cM

Sequence :: Chromosome: 19; NC_000085.6 (9872297..9899533, complement)

See Incenp in Epigenomics, MapViewer

Chromosome 19 - NC_000085.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

INCENP labels the spermatogonia synaptonemal complex central element from zygotene up to late pachytene when it begins to relocalize to heterochromatic chromocentres
Title: Dynamic relocalization of the chromosomal passenger complex proteins inner centromere protein (INCENP) and aurora-B kinase during male mouse meiosis.
INCENP recruits Aurora-C (or some other factor(s) recruit INCENP and Aurora-C) to meiotic chromosomes, while Aurora-C may either work alone or cooperate with Aurora-B to regulate chromosome segregation during male meiosis
Title: Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis.

Submit: New GeneRIF Correction

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:200760	BioGRID:112666	AURKA	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:200760	BioGRID:114646	AURKB	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:200760	BioGRID:106829	BIRC5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:200760	BioGRID:120446	CDCA8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:200760	BioGRID:109831	INCENP	BioGRID	PubMed	Affinity Capture-MS
BioGRID:200760	BioGRID:129767	PTRF	BioGRID	PubMed	Affinity Capture-MS

Process	Evidence Code	Pubs
cell cycle	IEA Inferred from Electronic Annotation more info
cell division	IEA Inferred from Electronic Annotation more info
chromosome segregation	ISO Inferred from Sequence Orthology more info
cytokinesis	ISO Inferred from Sequence Orthology more info
mitosis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
central element	IDA Inferred from Direct Assay more info	PubMed
centromeric heterochromatin	ISO Inferred from Sequence Orthology more info
chromosome	IEA Inferred from Electronic Annotation more info
chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
chromosome, centromeric region	ISA Inferred from Sequence Alignment more info	PubMed
chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
kinetochore	ISO Inferred from Sequence Orthology more info
microtubule	IEA Inferred from Electronic Annotation more info
midbody	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info
protein complex	ISO Inferred from Sequence Orthology more info
spindle	ISO Inferred from Sequence Orthology more info
synaptonemal complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: inner centromere protein

Names: inner centromere protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016692.3 → NP_057901.2 inner centromere protein

Status: VALIDATED

Source sequence(s)

AK081841, BE853584, BY788161

Consensus CDS

CCDS37912.1

UniProtKB/Swiss-Prot

Q9WU62

Related

ENSMUSP00000025562, ENSMUST00000025562

Conserved Domains (2) summary

pfam12178
Location:5 – 42
Blast Score: 110

INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal

pfam03941
Location:789 – 847
Blast Score: 211

INCENP_ARK-bind; Inner centromere protein, ARK binding region

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000085.6 Reference GRCm38 C57BL/6J

Range

9872297..9899533, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000041.1 Alternate Mm_Celera

Range

10569299..10596535, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC132253.5 (101723..128846)	None
genomic	AF116187.1	AAD26202.1	129/Sv
genomic	CH466534.1	EDL41328.1	mixed
mRNA	AB100432.1	BAC55879.1
mRNA	AB100433.1	BAC55880.1
mRNA	AF117610.1	AAD32094.1	129
mRNA	AK012497.1	None	C57BL/6J
mRNA	AK034764.1	None	C57BL/6J
mRNA	AK081841.1	BAC38346.1	C57BL/6J
mRNA	AK088627.1	BAC40462.1	NOD
mRNA	AK208659.1	None
mRNA	BC021761.2	None	CZECHII
mRNA	BC037011.1	AAH37011.1	FVB/N
mRNA	BC052414.1	AAH52414.1	C57BL/6
mRNA	BE853584.1	None	C57BL/6J
mRNA	BY788161.1	None	C57BL/6J