ZNF383 zinc finger protein 383 [Homo sapiens] - Gene

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Summary

Official Symbol: ZNF383provided by HGNC
Official Full Name: zinc finger protein 383provided by HGNC
Primary source: HGNC:18609
Locus tag: HSD17
See related: Ensembl:ENSG00000188283; HPRD:15786
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HSD17; FLJ35863

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Genomic context

Location :: 19q13.12

Sequence :: Chromosome: 19; NC_000019.9 (37717366..37734574)

See ZNF383 in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Overexpression of ZNF383 in cells inhibits the transcriptional activities of AP-1 and SRE, suggesting that ZNF383 may act as a negative regulator in MAPK-mediated signaling pathways.
Title: ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:127849	BioGRID:108431	EWSR1		BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
intracellular	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: zinc finger protein 383

Names: zinc finger protein 383

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152604.1 → NP_689817.1 zinc finger protein 383

Status: PROVISIONAL

Source sequence(s)

AK093182

Consensus CDS

CCDS12501.1

UniProtKB/Swiss-Prot

Q8NA42

Related

ENSP00000340132, ENST00000352998

Conserved Domains (3) summary

cd07765
Location:6 – 45
Blast Score: 204

KRAB_A-box; KRAB (Kruppel-associated box) domain -A box.

smart00349
Location:6 – 66
Blast Score: 296

KRAB; krueppel associated box

pfam13465
Location:436 – 461
Blast Score: 97

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p5 Primary Assembly

Range

37717366..37734574

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

34186317..34203908

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC012309.8 (139687..156895)	None
mRNA	AK091760.1	BAG52412.1
mRNA	AK093182.1	BAC04086.1
mRNA	AK122892.1	None
mRNA	AY260141.1	AAP20067.1
mRNA	AY438646.1	AAR14184.1
other-genetic	BC148612.1	AAI48613.1