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PHOSPHO1 phosphoethanolamine/phosphocholine phosphatase [ Homo sapiens (human) ]

Gene ID: 162466, updated on 12-May-2016
Official Symbol
PHOSPHO1provided by HGNC
Official Full Name
phosphoethanolamine/phosphocholine phosphataseprovided by HGNC
Primary source
HGNC:HGNC:16815
See related
Ensembl:ENSG00000173868 HPRD:17847; Vega:OTTHUMG00000161305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Orthologs
Location:
17q21.32
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (49223366..49231692, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47300728..47309009, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene transfer RNA-Gln (TTG) 1-1 Neighboring gene G protein subunit gamma transducin 2 Neighboring gene ABI family member 3 Neighboring gene uncharacterized LOC105371816 Neighboring gene uncharacterized FLJ40194 Neighboring gene microRNA 6129

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog
  • Glycerophospholipid biosynthesis, organism-specific biosystem (from REACTOME)
    Glycerophospholipid biosynthesis, organism-specific biosystemGlycerophospholipids are important structural and functional components of biological membranes and constituents of serum lipoproteins and the pulmonary surfactant. In addition, glycerophospholipids...
  • Glycerophospholipid metabolism, organism-specific biosystem (from KEGG)
    Glycerophospholipid metabolism, organism-specific biosystem
    Glycerophospholipid metabolism
  • Glycerophospholipid metabolism, conserved biosystem (from KEGG)
    Glycerophospholipid metabolism, conserved biosystem
    Glycerophospholipid metabolism
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Phospholipid metabolism, organism-specific biosystem (from REACTOME)
    Phospholipid metabolism, organism-specific biosystemPhospholipids contain a polar head group and two long-chain fatty acyl moieties, one of which is generally unsaturated. The head group is a glycerol or serine phosphate attached to a polar group such...
  • Synthesis of PC, organism-specific biosystem (from REACTOME)
    Synthesis of PC, organism-specific biosystemDe novo (Kennedy pathway) synthesis of phosphatidylcholine (PC) involves phosphorylation of choline (Cho) to phosphocholine (PCho) followed by condensing with cytidine triphosphate (CTP) to form CDP-...
  • Synthesis of PE, organism-specific biosystem (from REACTOME)
    Synthesis of PE, organism-specific biosystemDe novo (Kennedy pathway) synthesis of phosphatidylethanolamine (PE) involves phosphorylation of ethanolamine (ETA) to phosphoethanolamine (PETA) followed by condensing with cytidine triphosphate (CT...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
phosphocholine phosphatase activity EXP
Inferred from Experiment
more info
PubMed 
phosphoethanolamine phosphatase activity EXP
Inferred from Experiment
more info
PubMed 
pyrophosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
bone mineralization involved in bone maturation IBA
Inferred from Biological aspect of Ancestor
more info
 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
endochondral ossification IEA
Inferred from Electronic Annotation
more info
 
phosphatidylcholine biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylethanolamine biosynthetic process TAS
Traceable Author Statement
more info
 
regulation of bone mineralization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
phosphoethanolamine/phosphocholine phosphatase
Names
phosphatase, orphan 1
NP_001137276.1
NP_848595.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143804.1NP_001137276.1  phosphoethanolamine/phosphocholine phosphatase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AJ457189, BC029931
    Consensus CDS
    CCDS45726.1
    UniProtKB/Swiss-Prot
    Q8TCT1
    Related
    ENSP00000406909, ENST00000413580
    Conserved Domains (1) summary
    pfam06888
    Location:52289
    Put_Phosphatase; Putative Phosphatase
  2. NM_178500.3NP_848595.1  phosphoethanolamine/phosphocholine phosphatase isoform 2

    See identical proteins and their annotated locations for NP_848595.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site, compared to variant 1, that results in the use of an upstream start codon. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AJ457189
    Consensus CDS
    CCDS11547.1
    UniProtKB/Swiss-Prot
    Q8TCT1
    Related
    ENSP00000311925, OTTHUMP00000220006, ENST00000310544, OTTHUMT00000364467
    Conserved Domains (1) summary
    pfam06888
    Location:27264
    Put_Phosphatase; Putative Phosphatase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    49223366..49231692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721732.2XP_006721795.1  

    See identical proteins and their annotated locations for XP_006721795.1

    Conserved Domains (1) summary
    pfam06888
    Location:110347
    Put_Phosphatase; Putative Phosphatase
  2. XM_006721731.2XP_006721794.1  

    See identical proteins and their annotated locations for XP_006721794.1

    Conserved Domains (1) summary
    pfam06888
    Location:110347
    Put_Phosphatase; Putative Phosphatase
  3. XM_005257109.2XP_005257166.1  

    See identical proteins and their annotated locations for XP_005257166.1

    UniProtKB/Swiss-Prot
    Q8TCT1
    Conserved Domains (1) summary
    pfam06888
    Location:27264
    Put_Phosphatase; Putative Phosphatase

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    47365987..47373381 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)