Display Settings:

Format

Send to:

Choose Destination

DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) [ Homo sapiens (human) ]

Gene ID: 1621, updated on 22-Dec-2014
Official Symbol
DBHprovided by HGNC
Official Full Name
dopamine beta-hydroxylase (dopamine beta-monooxygenase)provided by HGNC
Primary source
HGNC:HGNC:2689
Locus tag
RP11-317B10.1
See related
Ensembl:ENSG00000123454; HPRD:01963; MIM:609312; Vega:OTTHUMG00000020878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DBM
Summary
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. [provided by RefSeq, Jul 2008]
Location:
9q34
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 9 NC_000009.12 (133636363..133659344)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (136501485..136524466)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ADAMTS-like 2 Neighboring gene family with sequence similarity 163, member B Neighboring gene DBH antisense RNA 1 Neighboring gene sarcosine dehydrogenase Neighboring gene vav 2 guanine nucleotide exchange factor Neighboring gene CDK5 and ABL1 enzyme substrate 2-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
 
catalytic activity TAS
Traceable Author Statement
more info
PubMed 
copper ion binding IEA
Inferred from Electronic Annotation
more info
 
dopamine beta-monooxygenase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
behavioral response to ethanol IEA
Inferred from Electronic Annotation
more info
 
blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
catecholamine biosynthetic process TAS
Traceable Author Statement
more info
 
cellular nitrogen compound metabolic process TAS
Traceable Author Statement
more info
 
cytokine production IEA
Inferred from Electronic Annotation
more info
 
dopamine catabolic process IEA
Inferred from Electronic Annotation
more info
 
fear response IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
homoiothermy IEA
Inferred from Electronic Annotation
more info
 
leukocyte mediated immunity IEA
Inferred from Electronic Annotation
more info
 
leukocyte migration IEA
Inferred from Electronic Annotation
more info
 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
maternal behavior IEA
Inferred from Electronic Annotation
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
norepinephrine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
response to pain IEA
Inferred from Electronic Annotation
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
visual learning IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromaffin granule lumen IEA
Inferred from Electronic Annotation
more info
 
chromaffin granule membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
secretory granule lumen TAS
Traceable Author Statement
more info
 
transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
dopamine beta-hydroxylase
Names
dopamine beta-hydroxylase
NP_000778.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008645.1 

    Range
    5001..27982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000787.3NP_000778.3  dopamine beta-hydroxylase precursor

    See proteins identical to NP_000778.3

    Status: REVIEWED

    Source sequence(s)
    AL365494, BC017174, CD014125, X13255
    Consensus CDS
    CCDS6977.2
    UniProtKB/Swiss-Prot
    P09172
    Related
    ENSP00000376776, OTTHUMP00000022501, ENST00000393056, OTTHUMT00000054929
    Conserved Domains (3) summary
    cd09631
    Location:51169
    DOMON_DOH; DOMON-like domain of copper-dependent monooxygenases and related proteins
    pfam01082
    Location:214343
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:359523
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000009.12 

    Range
    133636363..133659344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 

    Range
    136651448..136674425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000141.1 

    Range
    106002148..106025141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)