Il6st interleukin 6 signal transducer [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Il6stprovided by MGI
Official Full Name: interleukin 6 signal transducerprovided by MGI
Primary source: MGI:96560
See related: Ensembl:ENSMUSG00000021756
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD130; gp130; AA389424; BB405851; D13Ertd699e; 5133400A03Rik

Genomic context

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Location :: 13 D2.2; 13 63.73 cM

Sequence :: Chromosome: 13; NC_000079.6 (112464070..112506860)

See Il6st in Epigenomics, MapViewer

Chromosome 13 - NC_000079.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Analysis of the innate immune response and the regulation of hepatic antibacterial pathways showed that the LPS-triggered hepatocellular response via the Toll-like receptor-4 pathway was regulated differentially by HGF/c-Met and IL-6/gp130.
Title: Lack of hepatic c-Met and gp130 expression is associated with an impaired antibacterial response and higher lethality after bile duct ligation.
An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer.
Title: An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer.
Soluble interleukin-6 receptor induces motor stereotypies and co-localizes with gp130 in regions linked to cortico-striato-thalamo-cortical circuits
Title: Soluble interleukin-6 receptor induces motor stereotypies and co-localizes with gp130 in regions linked to cortico-striato-thalamo-cortical circuits.
Data unravel a vital function of IL-6/gp130-STAT1/3 signals for BM engraftment and haematopoiesis, as well as for host survival after transplantation.
Title: Differential role of gp130-dependent STAT and Ras signalling for haematopoiesis following bone-marrow transplantation.
These findings indicate a crucial protective function of gp130-expressing neurons in a model of chronic encephalitis.
Title: Neuronal gp130 expression is crucial to prevent neuronal loss, hyperinflammation, and lethal course of murine Toxoplasma encephalitis.
the mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling
Title: Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling.
Taking into account the gene penetrance, this can indicate effect of the gene i16st on choice of the active ("regulated") or passive ("dependent") way of the organism reacting to temperature actions.
Title: [Effect of transfer of fragment of chromosome 13, containing gene i16st on parameters of mouse temperature homeostasis].
both LIFR and gp130 protein expression were increased in the sciatic nerve and gastrocnemius muscle of diabetic mice.
Title: Early changes of LIFR and gp130 in sciatic nerve and muscle of diabetic mice.
Results point to a role of sgp130 in the blockade of classic signaling and indicate that in vivo only low therapeutic concentrations of sgp130Fc guarantee blockade of IL-6 trans-signaling without affecting IL-6 classic signaling.
Title: Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor.
Hyper-interleukin-11 novel designer molecular adjuvant directly targets gp130 leading to induction of specific and long lasting anticancer immune response.
Title: Hyper-interleukin-11 novel designer molecular adjuvant targeting gp130 for whole cell cancer vaccines.

Submit: New GeneRIF Correction See all (80)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (3) 1 citation
Targeted (knock-out) (4) 1 citation
Targeted (knock-in) (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NC_000079.1	NP_033309.2	Stat1	BIND	PubMed	Phosphorylated Stat1 interacts with IL6ST (GP130) promoter.
NC_000079.1		Stat3	BIND	PubMed	Stat3 interacts with IL6ST (GP130) promoter.
NC_000079.1			BIND	PubMed	Stat3-Crebbp (Stat3-CBP) complex interacts with IL6ST (GP130) promoter.
NP_034690.2	NP_034853.1	Lmo4	BIND	PubMed	LMO4 interacts with gp130.
BioGRID:200643	BioGRID:107315	CBL	BioGRID	PubMed	Affinity Capture-Western
BioGRID:200643	BioGRID:198795	Cntf	BioGRID	PubMed	Affinity Capture-Western
BioGRID:200643	BioGRID:232625	Ctf2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:200643	BioGRID:200296	Hgs	BioGRID	PubMed	Affinity Capture-Western
BioGRID:200643	BioGRID:111745	PTPN11	BioGRID	PubMed	Affinity Capture-Western
BioGRID:200643	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Pathways from BioSystems

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Adipogenesis, organism-specific biosystem (from WikiPathways)
Adipogenesis, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
ESC Pluripotency Pathways, organism-specific biosystem (from WikiPathways)
ESC Pluripotency Pathways, organism-specific biosystemThe cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is als...
IL-6 signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-6 signaling Pathway, organism-specific biosystem
IL-6 signaling Pathway
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interleukin-6 signaling, organism-specific biosystem (from REACTOME)
Interleukin-6 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Jak-STAT signaling pathway, conserved biosystem (from KEGG)
Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted inter...
PluriNetWork, organism-specific biosystem (from WikiPathways)
PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
Signaling by Interleukins, organism-specific biosystem (from REACTOME)
Signaling by Interleukins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Viral carcinogenesis, organism-specific biosystem (from KEGG)
Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Viral carcinogenesis, conserved biosystem (from KEGG)
Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237111

NoName (e-PCR)
- UniSTS:237112

M83336 (e-PCR)
- UniSTS:124989

Il6st (e-PCR), detects polymorphism
- UniSTS:259184

X62646 (e-PCR)
- UniSTS:180600

AU015818 (e-PCR)
- UniSTS:167123

Homology

Homologs of the Il6st gene: The Il6st gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ciliary neurotrophic factor receptor activity	ISO Inferred from Sequence Orthology more info
ciliary neurotrophic factor receptor binding	ISO Inferred from Sequence Orthology more info
cytokine receptor activity	IEA Inferred from Electronic Annotation more info
growth factor binding	ISO Inferred from Sequence Orthology more info
contributes_to interleukin-11 binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to interleukin-11 receptor activity	IDA Inferred from Direct Assay more info	PubMed
interleukin-6 receptor activity	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
ciliary neurotrophic factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
glycogen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
interleukin-27-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
leukemia inhibitory factor signaling pathway	ISO Inferred from Sequence Orthology more info
negative regulation of interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
oncostatin-M-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of astrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of tyrosine phosphorylation of Stat1 protein	ISO Inferred from Sequence Orthology more info
positive regulation of tyrosine phosphorylation of Stat3 protein	ISO Inferred from Sequence Orthology more info
reduction of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
signal transduction	IDA Inferred from Direct Assay more info	PubMed
triglyceride mobilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
cell body	IDA Inferred from Direct Assay more info	PubMed
ciliary neurotrophic factor receptor complex	ISO Inferred from Sequence Orthology more info
dendrite	IDA Inferred from Direct Assay more info	PubMed
external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
extracellular space	ISO Inferred from Sequence Orthology more info
integral to membrane	IEA Inferred from Electronic Annotation more info
interleukin-6 receptor complex	ISO Inferred from Sequence Orthology more info
membrane	IEA Inferred from Electronic Annotation more info
neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
oncostatin-M receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-6 receptor subunit beta

Names: interleukin-6 receptor subunit beta; IL-6RB; IL-6R-beta; IL-6R subunit beta; membrane glycoprotein 130; IL-6 receptor subunit beta; interleukin-6 signal transducer; oncostatin-M receptor subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010560.3 → NP_034690.3 interleukin-6 receptor subunit beta precursor

Status: VALIDATED

Source sequence(s)

BC058679, BU709006, CJ177012, CV556562

Consensus CDS

CCDS26773.1

UniProtKB/Swiss-Prot

Q00560

UniProtKB/TrEMBL

Q6PDI9

Related

ENSMUSP00000064205, ENSMUST00000070731

Conserved Domains (3) summary

cd00063
Location:257 – 319
Blast Score: 112

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:24 – 114
Blast Score: 303

Lep_receptor_Ig; Ig-like C2-type domain

cl12153
Location:125 – 213
Blast Score: 104

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000079.6 Reference GRCm38.p1 C57BL/6J

Range

112464070..112506860

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000035.1 Alternate Mm_Celera

Range

116768393..116811051

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01110217.1 (6724..49382)	None
genomic	AC159196.2 (57210..99942)	None
genomic	CH466568.2	EDL18412.1	mixed
mRNA	AK017211.1	None	C57BL/6J
mRNA	AK142637.1	BAE25142.1	C57BL/6J
mRNA	AK170020.1	BAE41514.1	NOD
mRNA	BC009665.1	None
mRNA	BC020454.1	None	FVB/N
mRNA	BC049887.1	None	FVB/N-3
mRNA	BC058551.1	None	FVB/N-3
mRNA	BC058679.1	AAH58679.1	C57BL/6
mRNA	BU709006.1	None	C57BL/6
mRNA	CJ177012.1	None
mRNA	CV556562.1	None	C57BL/6
mRNA	M83336.1	AAA37723.1	ICR
mRNA	X62646.1	CAA44515.1	ICR