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Il2rb interleukin 2 receptor, beta chain [ Mus musculus (house mouse) ]

Gene ID: 16185, updated on 28-May-2016
Official Symbol
Il2rbprovided by MGI
Official Full Name
interleukin 2 receptor, beta chainprovided by MGI
Primary source
MGI:MGI:96550
See related
Ensembl:ENSMUSG00000068227
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p70; CD122; IL15Rbeta; Il-2Rbeta; IL-15Rbeta; Il-2/15Rbeta
Summary
The interleukin 2 receptor is composed of alpha and beta subunits. The beta subunit encoded by this gene is very homologous to the human beta subunit and also shows structural similarity to other cytokine receptors. [provided by RefSeq, Jul 2008]
Orthologs
Location:
15 37.52 cM; 15 E
Exon count:
14
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 15 NC_000081.6 (78479256..78511627, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (78310978..78325496, complement)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerisation domain containing 17 Neighboring gene transmembrane serine protease 6 Neighboring gene C1q and tumor necrosis factor related protein 6 Neighboring gene somatostatin receptor 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • MGC118674

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
interleukin-2 binding IPI
Inferred from Physical Interaction
more info
PubMed 
interleukin-2 binding ISO
Inferred from Sequence Orthology
more info
 
interleukin-2 receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
natural killer cell activation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
interleukin-2 receptor subunit beta
Names
IL-15 receptor beta chain
IL-2 receptor beta chain
IL-2 receptor subunit beta
IL-2/15 receptor-beta
IL-2R subunit beta
IL-2RB
high affinity IL-2 receptor subunit beta
p70-75

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008368.4NP_032394.1  interleukin-2 receptor subunit beta precursor

    See identical proteins and their annotated locations for NP_032394.1

    Status: REVIEWED

    Source sequence(s)
    AK017288, BQ033566
    Consensus CDS
    CCDS27616.1
    UniProtKB/Swiss-Prot
    P16297
    Related
    ENSMUSP00000086820, ENSMUST00000089398
    Conserved Domains (1) summary
    cd00063
    Location:135232
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p3 C57BL/6J

    Range
    78479256..78511627 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520478.2XP_006520541.1  

    See identical proteins and their annotated locations for XP_006520541.1

    UniProtKB/Swiss-Prot
    P16297
    Conserved Domains (1) summary
    cd00063
    Location:135232
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_006520477.2XP_006520540.1  

    See identical proteins and their annotated locations for XP_006520540.1

    UniProtKB/Swiss-Prot
    P16297
    Conserved Domains (1) summary
    cd00063
    Location:135232
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. XM_006520479.2XP_006520542.1  

    See identical proteins and their annotated locations for XP_006520542.1

    UniProtKB/Swiss-Prot
    P16297
    Conserved Domains (1) summary
    cd00063
    Location:135232
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  4. XM_006520480.2XP_006520543.1  

    See identical proteins and their annotated locations for XP_006520543.1

    UniProtKB/Swiss-Prot
    P16297
    Related
    ENSMUSP00000127006, ENSMUST00000163494
    Conserved Domains (1) summary
    cd00063
    Location:135232
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  5. XM_006520481.1XP_006520544.1  

    See identical proteins and their annotated locations for XP_006520544.1

    UniProtKB/Swiss-Prot
    P16297
    Conserved Domains (1) summary
    cd00063
    Location:135232
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Alternate Mm_Celera

Genomic

  1. AC_000037.1 Alternate Mm_Celera

    Range
    79943154..79957670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)