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    Il1b interleukin 1 beta [ Mus musculus (house mouse) ]

    Gene ID: 16176, updated on 19-May-2013
    Official Symbol
    Il1bprovided by MGI
    Official Full Name
    interleukin 1 betaprovided by MGI
    Primary source
    MGI:96543
    Locus tag
    RP23-384K11.2
    See related
    Ensembl:ENSMUSG00000027398; Vega:OTTMUSG00000015509
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Il-1b; IL-1beta
    Location :
    2 F; 2 62.97 cM
    Sequence :
    Chromosome: 2; NC_000068.7 (129364579..129371120, complement)
    See Il1b in Epigenomics, MapViewer

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene 14023 Neighboring gene interleukin 1 alpha Neighboring gene Casitas B-lineage lymphoma pseudogene Neighboring gene predicted gene 14047 Neighboring gene signal peptidase complex subunit 2, pseudogene Neighboring gene RIKEN cDNA F830045P16 gene

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Tannahill GM, et al. Nature, 2013 Apr 11. PMID 23535595.
    2. MFGE8 inhibits inflammasome-induced IL-1β production and limits postischemic cerebral injury. Deroide N, et al. J Clin Invest, 2013 Mar 1. PMID 23454767.
    3. Caspase-11 protects against bacteria that escape the vacuole. Aachoui Y, et al. Science, 2013 Feb 22. PMID 23348507.
    4. Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Takasuga S, et al. Proc Natl Acad Sci U S A, 2013 Jan 29. PMID 23322734.
    5. Role of the inflammasome in defense against venoms. Palm NW, et al. Proc Natl Acad Sci U S A, 2013 Jan 29. PMID 23297192.

    See all (589) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. MFGE8 regulates innate immunity through inhibition of inflammasome-induced IL-1beta production.
      Title: MFGE8 inhibits inflammasome-induced IL-1β production and limits postischemic cerebral injury.
    2. there was no evidence of significant association between IL-1beta -31 C/T polymorphism and DU with or without Helicobacter pylori infection in overall population.
      Title: No association between IL-1β -31 C/T polymorphism and the risk of duodenal ulcer: a meta-analysis of 3793 subjects.
    3. show that bee venom detected by inflammasome and trigger activation of caspase-1 and secretion of proinflammatory cytokine IL-1beta is pyrin domain-containing 3 NLRP3, apoptosis-associated speck-like protein ASC, and IL-1 receptor dependent.
      Title: Role of the inflammasome in defense against venoms.
    4. inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1beta but not tumour-necrosis factor-alpha in mouse macrophages
      Title: Succinate is an inflammatory signal that induces IL-1β through HIF-1α.
    5. Compared to C57BL/6 mice, MRL/MpJ mice had less severe inflammation following joint injury, lower gene expression of tumor necrosis factor alpha and IL-1beta in the synovial tissue and lower protein levels of IL-1alpha and IL-1beta in the synovial fluid.
      Title: Genetic and cellular evidence of decreased inflammation associated with reduced incidence of posttraumatic arthritis in MRL/MpJ mice.
    6. IL-1beta and neutrophil abscess formation during an infection are functionally, temporally and spatially linked as a consequence of direct IL-1beta production by neutrophils.
      Title: Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice.
    7. Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1beta and IL-18 secretion but not to pyroptosis.
      Title: Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1β and IL-18 secretion but not to pyroptosis.
    8. Data indicate in TLR4(-/-) mice, higher expression levels of IL-1beta and lower expression levels of VEGF, RANK, RANKL and OPG were detected at late time points (> postoperative 4 days).
      Title: Accelerated calvarial healing in mice lacking Toll-like receptor 4.
    9. Deubiquitinases regulate the activity of caspase-1 and interleukin-1beta secretion via assembly of the inflammasome
      Title: Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome.
    10. Data indicate that epithelial Gli2 expression was sufficient to stimulate Il-1beta expression, repress Gast gene expression and increase proliferation, leading to antral hyperplasia.
      Title: Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia.
    Submit: New GeneRIF Correction See all (294)
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:200624 BioGRID:201248 Il1rl1    BioGRID  PubMed Affinity Capture-Western 
    • African trypanosomiasis, organism-specific biosystem (from KEGG)
      African trypanosomiasis, organism-specific biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
    • African trypanosomiasis, conserved biosystem (from KEGG)
      African trypanosomiasis, conserved biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokines and Inflammatory Response (BioCarta), organism-specific biosystem (from WikiPathways)
      Cytokines and Inflammatory Response (BioCarta), organism-specific biosystemSee BioCarta version: http://www.biocarta.com/pathfiles/h_inflamPathway.asp
    • Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Cytosolic DNA-sensing pathway, conserved biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Graft-versus-host disease, organism-specific biosystem (from KEGG)
      Graft-versus-host disease, organism-specific biosystemGraft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells....
    • Graft-versus-host disease, conserved biosystem (from KEGG)
      Graft-versus-host disease, conserved biosystemGraft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells....
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • IL-1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-1 Signaling Pathway, organism-specific biosystemThe interleukin 1 family of cytokines includes interleukin-1 alpha (IL1A), beta (IL1B) and the IL-1 receptor antagonist (IL1RN). These bind to the IL-1 receptor (IL1R1) as well as its decoy receptor,...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Interleukin-1 processing, organism-specific biosystem (from REACTOME)
      Interleukin-1 processing, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-1 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
      Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
      Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystem
      Myometrial Relaxation and Contraction Pathways
    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
      NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • PI3K/Akt/mTOR signaling pathway, organism-specific biosystem (from LIPID MAPS)
      PI3K/Akt/mTOR signaling pathway, organism-specific biosystem
      PI3K/Akt/mTOR signaling pathway
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Prion diseases, organism-specific biosystem (from KEGG)
      Prion diseases, organism-specific biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
    • Prion diseases, conserved biosystem (from KEGG)
      Prion diseases, conserved biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
    • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
      Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Rheumatoid arthritis, conserved biosystem (from KEGG)
      Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Salmonella infection, organism-specific biosystem (from KEGG)
      Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Salmonella infection, conserved biosystem (from KEGG)
      Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
    • TLR4 (Toll-like receptor 4) signaling pathway, organism-specific biosystem (from LIPID MAPS)
      TLR4 (Toll-like receptor 4) signaling pathway, organism-specific biosystem
      TLR4 (Toll-like receptor 4) signaling pathway
    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Type I diabetes mellitus, organism-specific biosystem (from KEGG)
      Type I diabetes mellitus, organism-specific biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Type I diabetes mellitus, conserved biosystem (from KEGG)
      Type I diabetes mellitus, conserved biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
      Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytokine activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    interleukin-1 receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    aging ISO
    Inferred from Sequence Orthology
    more info
    		  
    cellular response to drug ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    		  
    cellular response to organic substance ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    elevation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    fever generation IEA
    Inferred from Electronic Annotation
    more info
    		  
    hyaluronan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    interleukin-1 beta production IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    leukocyte migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    monocyte aggregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of adiponectin secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of branching morphogenesis of a nerve ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of glucose transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of glutamate secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    neutrophil chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of I-kappaB kinase/NF-kappaB cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of NF-kappaB import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of astrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of calcidiol 1-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of chemokine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of fever generation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of glial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of granulocyte macrophage colony-stimulating factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of interferon-gamma production ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of interleukin-2 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of interleukin-6 biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of lipid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of mitosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of monocyte chemotactic protein-1 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of myosin light chain kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of prostaglandin secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of transcription, DNA-dependent ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation vascular endothelial growth factor production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein kinase B signaling cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    regulation of I-kappaB kinase/NF-kappaB cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    response to ATP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to ATP IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    response to chemical stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    sequestering of triglyceride ISO
    Inferred from Sequence Orthology
    more info
    		  
    social behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    secretory granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    interleukin-1 beta
    Names
    interleukin-1 beta
    IL-1 beta

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008361.3 → NP_032387.1  interleukin-1 beta precursor

      Status: PROVISIONAL

      Source sequence(s)
      AL808143
      Consensus CDS
      CCDS16726.1
      UniProtKB/Swiss-Prot
      P10749
      UniProtKB/TrEMBL
      Q2M4J6
      Related
      ENSMUSP00000028881, OTTMUSP00000016525, ENSMUST00000028881, OTTMUST00000036830
      Conserved Domains (2) summary
      cd00100
      Location:124 – 265
      Blast Score: 526
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
      pfam02394
      Location:1 – 102
      Blast Score: 397
      IL1_propep; Interleukin-1 propeptide

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p1 C57BL/6J

      Range
      129364579..129371120, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000024.1 Alternate Mm_Celera

      Range
      130592096..130598637, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01020661.1 (1676..8217) None
    genomic AL808143.5 (12892..19434) None
    genomic AY902319.1 AAX90604.1 CAST/EiJ
    genomic CH466519.1 EDL28238.1 mixed
    genomic U03987.1 None DBA/2J
    genomic X04964.1 CAA28637.1
    mRNA AK156396.1 None NOD
    mRNA AK157245.1 None NOD
    mRNA AK168047.1 BAE40029.1 BALB/c
    mRNA AK224980.1 None NOD
    mRNA AK225002.1 None C57BL/6J
    mRNA AK225003.1 None C57BL/6J
    mRNA BC011437.1 AAH11437.1 CZECHII
    mRNA M15131.1 AAA39276.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10749.1 GenPept UniProtKB/Swiss-Prot:P10749

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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