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    DAXX death-domain associated protein [ Homo sapiens ]

    Gene ID: 1616, updated on 19-May-2012
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    Summary

    Official Symbol
    DAXXprovided by HGNC
    Official Full Name
    death-domain associated proteinprovided by HGNC
    Primary source
    HGNC:2681
    Locus tag
    DADB-159G18.9
    See related
    Ensembl:ENSG00000204209; HPRD:04424; MIM:603186; Vega:OTTHUMG00000031203
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DAP6; EAP1; BING2; MGC126245; MGC126246
    Summary
    This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
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    Genomic context

    Location :
    6p21.3
    Sequence :
    Chromosome: 6; NC_000006.11 (33286335..33290793, complement)
    See DAXX in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene TAP binding protein (tapasin) Neighboring gene zinc finger and BTB domain containing 22 Neighboring gene myosin, light chain 8, pseudogene Neighboring gene lysophospholipase II pseudogene 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Death-associated protein 6 (Daxx) mediates cAMP-dependent stimulation of Cyp11a1 (P450scc) transcription. Lan HC, et al. J Biol Chem, 2012 Feb 17. PMID 22199361.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. General blockade of human cytomegalovirus immediate-early mRNA expression in the S/G2 phase by a nuclear, Daxx- and PML-independent mechanism. Zydek M, et al. J Gen Virol, 2011 Dec. PMID 21832009.

    See all (152) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Daxx mediates apoptosis through the Fas-Daxx-ASK1-JNK1 signaling pathway.
      Title: FTH1 binds to Daxx and inhibits Daxx-mediated cell apoptosis.
    2. Daxx, a HIPK kinase substrate in the apoptosis pathway, was phosphorylated by HIPK3 at Ser-669 in response to cAMP stimulation.
      Title: Death-associated protein 6 (Daxx) mediates cAMP-dependent stimulation of Cyp11a1 (P450scc) transcription.
    3. Neither Daxx nor PML, the main players of ND10-based immunity, are required for the block to viral gene expression in the S/G2 phase.
      Title: General blockade of human cytomegalovirus immediate-early mRNA expression in the S/G2 phase by a nuclear, Daxx- and PML-independent mechanism.
    4. The results confirm the significance of apoptosis deregulation in CLL, and suggest a possible relationship between DAXX expression and the clinical course of the disease.
      Title: Assessment of the pathway of apoptosis involving PAR-4, DAXX and ZIPK proteins in CLL patients and its relationship with the principal prognostic factors.
    5. alternative splicing of Daxx might indicate an additional level in the cellular apoptosis network.
      Title: Daxx-beta and Daxx-gamma, two novel splice variants of the transcriptional co-repressor Daxx.
    6. study found 61% of pancreatic neuroendocrine tumors had abnormal telomeres; all of the tumors with abnormal telomeres had ATRX or DAXX mutations or loss of nuclear ATRX or DAXX protein
      Title: Altered telomeres in tumors with ATRX and DAXX mutations.
    7. Characterizing the N- and C-terminal Small ubiquitin-like modifier (SUMO)-interacting motifs of the scaffold protein DAXX.
      Title: Characterizing the N- and C-terminal Small ubiquitin-like modifier (SUMO)-interacting motifs of the scaffold protein DAXX.
    8. Using the transcriptional coregulator Daxx as a model, we show that SUMO paralog-selective binding and conjugation are regulated by phosphorylation of the Daxx SUMO-interacting motif (SIM).
      Title: Structural and functional roles of Daxx SIM phosphorylation in SUMO paralog-selective binding and apoptosis modulation.
    9. Structural characterization of the DAXX N-terminal helical bundle domain and its complex with Rassf1C.
      Title: Structural characterization of the DAXX N-terminal helical bundle domain and its complex with Rassf1C.
    10. identification of mutations in pancreatic neuroendocrine tumors; 44% had somatic inactivating mutations in MEN1; 43% had mutations in genes encoding DAXX and ATRX; clinically, mutations in MEN1 and DAXX/ATRX genes were associated with better prognosis
      Title: DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors.
    Submit: New GeneRIF Correction See all (76)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001341.1 NP_003870.3 CFLAR    BIND  PubMed c-FLIP(L) interacts with Daxx. 
    NP_001341.1 NP_004371.1 CREBBP    BIND  PubMed CBP interacts with Daxx. 
    NP_001341.1 CAA32903.1 ETS1    BIND  PubMed Daxx interacts with p42-ETS1. 
    NP_001341.1 NP_005229.1 ETS1    BIND  PubMed Daxx interacts with p51-ETS1. 
    NP_001341.1 NP_006328.2 MCRS1    BIND  PubMed Daxx interacts with MCRS1 (MSP58). 
    NP_001341.1 NP_057953.1 PAX5    BIND  PubMed Pax5 interacts with Daxx. 
    NP_001341.1 CAA43370.1 PUUVsSgp1    BIND  PubMed Puumala virus nucleocapsid protein N interacts with Daxx. 
    NP_001341.1 NP_003343.1 SUMO1    BIND  PubMed Daxx interacts with sentrin. 
    NP_001341.1 SUMO1    BIND  PubMed Daxx interacts with an unspecified isoform of SUMO1. 
    NP_001341.1 NP_003336.1 UBE2I    BIND  PubMed Daxx interacts with Ubc9. 
    NP_001341.1 DAA00550.1     BIND  PubMed Ad12 E1B interacts with Daxx. 
    NP_001341.1 DAA00622.1     BIND  PubMed Ad2 E1B interacts with Daxx. 
    Q9UER7 P10275 AR    HPRD  PubMed  
    Q9UER7 P46100 ATRX    HPRD  PubMed  
    Q9UER7 NDP52 CALCOCO2    HPRD  PubMed  
    Q9UER7 Q03188 CENPC1    HPRD  PubMed  
    Q9UER7 O15519 CFLAR    HPRD  PubMed  
    Q9UER7 Q92793 CREBBP    HPRD  PubMed  
    Q9UER7 O43293 DAPK3    HPRD  PubMed  
    Q9UER7 Q9UER7 DAXX    HPRD  PubMed  
    Q9UER7 Q9NPF5 DMAP1    HPRD  PubMed  
    Q9UER7 P26358 DNMT1    HPRD  PubMed  
    Q9UER7 P62508 ESRRG    HPRD  PubMed  
    Q9UER7 P14921 ETS1    HPRD  PubMed  
    Q9UER7 P25445 FAS    HPRD  PubMed  
    Q9UER7 P48023 FASLG    HPRD  PubMed  
    Q9UER7 Q5JVS0 HABP4    HPRD  PubMed  
    Q9UER7 Q13547 HDAC1    HPRD  PubMed  
    Q9UER7 Q92769 HDAC2    HPRD  PubMed  
    Q9UER7 O15379 HDAC3    HPRD  PubMed  
    Q9UER7 Q86Z02 HIPK1    HPRD  PubMed  
    Q9UER7 Q9H2X6 HIPK2    HPRD  PubMed  
    Q9UER7 Q9H422 HIPK3    HPRD  PubMed  
    Q9UER7 Q00613 HSF1    HPRD  PubMed  
    Q9UER7 P04792 HSPB1    HPRD  PubMed  
    Q9UER7 Q99683 MAP3K5    HPRD  PubMed  
    Q9UER7 Q96EZ8 MCRS1    HPRD  PubMed  
    Q9UER7 Q00987 MDM2    HPRD  PubMed  
    Q9UER7 P20591 MX1    HPRD  PubMed  
    Q9UER7 Q99497 PARK7    HPRD  PubMed  
    Q9UER7 P23760 PAX3    HPRD  PubMed  
    Q9UER7 Q02548 PAX5    HPRD  PubMed  
    Q9UER7 P29590 PML    HPRD  PubMed  
    Q9UER7 Q9NS23 RASSF1    HPRD  PubMed  
    Q9UER7 SERPINE1 mRNA binding protein 1 SERBP1    HPRD  PubMed  
    Q9UER7 P14672 SLC2A4    HPRD  PubMed  
    Q9UER7 Q13573 SNW1    HPRD  PubMed  
    Q9UER7 P16150 SPN    HPRD  PubMed  
    Q9UER7 P40763 STAT3    HPRD  PubMed  
    Q9UER7 P63165 SUMO1    HPRD  PubMed  
    Q9UER7 Q9NQB0 TCF7L2    HPRD  PubMed  
    Q9UER7 P01137 TGFB1    HPRD  PubMed  
    Q9UER7 P37173 TGFBR2    HPRD  PubMed  
    Q9UER7 P04637 TP53    HPRD  PubMed  
    Q9UER7 Q9H3D4 TP63    HPRD  PubMed  
    Q9UER7 O15350 TP73    HPRD  PubMed  
    Q9UER7 Q99816 TSG101    HPRD  PubMed  
    Q9UER7 P63279 UBE2I    HPRD  PubMed  
    Q9UER7 Q93009 USP7    HPRD  PubMed  
    BioGRID:107985 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107985 BioGRID:107028 ATRX    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-purification; Reconstituted Complex 
    BioGRID:107985 BioGRID:113909 AXIN1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107985 BioGRID:107225 CA12    BioGRID  PubMed Two-hybrid 
    BioGRID:107985 BioGRID:107463 CDKN2A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107985 BioGRID:107489 CENPC1    BioGRID  PubMed Two-hybrid 
    BioGRID:107985 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107985 BioGRID:107983 DAPK3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107985 BioGRID:113643 DEK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107985 BioGRID:121004 DMAP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107985 BioGRID:108123 DNMT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107985 BioGRID:108414 ETS1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107985 BioGRID:108472 FANCA    BioGRID  PubMed Two-hybrid 
    BioGRID:107985 BioGRID:106851 FAS    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107985 BioGRID:199594 Fas    BioGRID  PubMed Two-hybrid 
    BioGRID:107985 BioGRID:109272 H3F3A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107985 BioGRID:116587 HABP4    BioGRID  PubMed Two-hybrid 
    BioGRID:107985 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Far Western; Reconstituted Complex 
    BioGRID:107985 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:107985 BioGRID:114368 HDAC3    BioGRID  PubMed Far Western 
    BioGRID:107985 BioGRID:128490 HIPK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107985 BioGRID:118815 HIPK2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107985 BioGRID:113955 HIST1H4A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107985 BioGRID:110381 MAP3K5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107985 BioGRID:115710 MCRS1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107985 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107985 BioGRID:110684 MX1    BioGRID  PubMed Two-hybrid 
    BioGRID:107985 BioGRID:110714 MYH11    BioGRID  PubMed Two-hybrid 
    BioGRID:107985 BioGRID:109165 NR3C1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107985 BioGRID:111111 PAX3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107985 BioGRID:111113 PAX5    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107985 BioGRID:111341 PLAGL1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107985 BioGRID:111384 PML    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization; Two-hybrid 
    BioGRID:107985 BioGRID:202032 Pax5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107985 BioGRID:116356 RASSF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107985 BioGRID:111903 RELB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107985 BioGRID:112057 RPL13    BioGRID  PubMed Two-hybrid 
    BioGRID:107985 BioGRID:971429 RS1    BioGRID  PubMed Co-localization 
    BioGRID:107985 BioGRID:112408 SLC2A4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107985 BioGRID:110264 SMAD4    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107985 BioGRID:115563 STUB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107985 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:107985 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS; Co-crystal Structure; Reconstituted Complex 
    BioGRID:107985 BioGRID:112791 TCF3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107985 BioGRID:112787 TCF4    BioGRID  PubMed Two-hybrid 
    BioGRID:107985 BioGRID:112900 TGFB2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107985 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107985 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107985 BioGRID:113177 UBE2I    BioGRID  PubMed Biochemical Activity; Two-hybrid 
    BioGRID:107985 BioGRID:113622 USP7    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
      FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
    • HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem (from Pathway Interaction Database)
      HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem
      HIV-1 Nef: Negative effector of Fas and TNF-alpha
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • TGF-beta receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      TGF-beta receptor signaling, organism-specific biosystem
      TGF-beta receptor signaling
    • p38 MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      p38 MAPK Signaling Pathway, organism-specific biosystemp38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases...
    • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
      p53 pathway, organism-specific biosystem
      p53 pathway

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    androgen receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    heat shock protein binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    p53 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    receptor signaling protein activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    activation of JUN kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    androgen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytokinesis after mitosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    induction of apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    induction of apoptosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    induction of apoptosis via death domain receptors TAS
    Traceable Author Statement
    more info
    		 PubMed 
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    PML body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    PML body IEA
    Inferred from Electronic Annotation
    more info
    		  
    PML body TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    heterochromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    death domain-associated protein 6
    Names
    death domain-associated protein 6
    Fas-binding protein
    CENP-C binding protein
    ETS1-associated protein 1
    death-associated protein 6
    fas death domain-associated protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001141969.1 → NP_001135441.1  death domain-associated protein 6 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript but encodes the shorter isoform (a). Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AK223404, BC073776, BM997178, DC359186
      Consensus CDS
      CCDS4776.1
      UniProtKB/TrEMBL
      Q53F85
      UniProtKB/Swiss-Prot
      Q9UER7
      Related
      ENSP00000363668, OTTHUMP00000029289, ENST00000374542, OTTHUMT00000076403
      Conserved Domains (1) summary
      pfam03344
      Location:1 – 740
      Blast Score: 1735
      Daxx; Daxx Family

    2. NM_001141970.1 → NP_001135442.1  death domain-associated protein 6 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame segment in a 5' coding exon and uses an upstream start codon, compared to variant 1. The resulting protein (isoform b) has a distinct and longer N-terminus, compared to isoform a.
      Source sequence(s)
      AK303767, AL662820, BM997178
      UniProtKB/TrEMBL
      B4E1C1
      Conserved Domains (1) summary
      pfam03344
      Location:18 – 752
      Blast Score: 1715
      Daxx; Daxx Family

    3. NM_001254717.1 → NP_001241646.1  death domain-associated protein 6 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (c) with a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AA533586, AK303854, AL662820
      UniProtKB/TrEMBL
      B4E1I3
      UniProtKB/TrEMBL
      F5H082
      Conserved Domains (1) summary
      pfam03344
      Location:1 – 665
      Blast Score: 1684
      Daxx; Daxx Family

    4. NM_001350.4 → NP_001341.1  death domain-associated protein 6 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AF050179, BM997178, DC345308
      Consensus CDS
      CCDS4776.1
      UniProtKB/Swiss-Prot
      Q9UER7
      Related
      ENSP00000266000, OTTHUMP00000029290, ENST00000266000, OTTHUMT00000076404
      Conserved Domains (1) summary
      pfam03344
      Location:1 – 740
      Blast Score: 1735
      Daxx; Daxx Family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      33286335..33290793, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.2 Reference GRCh37.p5 ALT_REF_LOCI_2

      Range
      4730149..4734611, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.1 Reference GRCh37.p5 ALT_REF_LOCI_3

      Range
      4567658..4572120, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.1 Reference GRCh37.p5 ALT_REF_LOCI_5

      Range
      4760078..4764535, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.1 Reference GRCh37.p5 ALT_REF_LOCI_6

      Range
      4518583..4523042, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      33027906..33032806, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL662820.6 (47560..52019) None
    genomic AL662827.3 (45570..50032) None
    genomic BX248088.18 CAI41788.1
      CAI95544.1
      CAI95545.1
    genomic CH471081.1 EAX03722.1
      EAX03723.1
      EAX03724.1
    genomic CR759786.5 CAQ08265.1
    genomic CR759817.3 CAQ08035.1
    genomic Z97183.1 CAB09986.2
    genomic Z97184.1 CAB09989.2
    mRNA AA533586.1 None
    mRNA AF006041.1 AAB63043.1
    mRNA AF015956.2 AAB66585.2
    mRNA AF039136.1 AAB92671.1
    mRNA AF050179.1 AAC39853.1
    mRNA AF097742.1 AAC72843.1
    mRNA AK223404.1 BAD97124.1
    mRNA AK292187.1 BAF84876.1
    mRNA AK303767.1 BAG64733.1
    mRNA AK303854.1 BAG64795.1
    mRNA AK309612.1 None
    mRNA AK313034.1 BAG35867.1
    mRNA BC000220.1 AAH00220.1
    mRNA BC073776.1 None
    mRNA BC109073.1 AAI09074.1
    mRNA BC109074.1 AAI09075.1
    mRNA BM997178.1 None
    mRNA CR457085.1 CAG33366.1
    mRNA DC345308.1 None
    mRNA DC359186.1 None
    mRNA HQ436528.1 AEC33235.1
    mRNA HQ436529.1 AEC33236.1
    mRNA AB209493.1 BAD92730.1
    other-genetic EU446949.1 ABZ92478.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4VX54 GenPept UniProtKB/TrEMBL:Q4VX54
    Q53F85 GenPept UniProtKB/TrEMBL:Q53F85
    Q59FG7 GenPept UniProtKB/TrEMBL:Q59FG7
    Q5STK8 GenPept UniProtKB/TrEMBL:Q5STK8
    Q5STR5 GenPept UniProtKB/TrEMBL:Q5STR5
    Q9UER7.2 GenPept UniProtKB/Swiss-Prot:Q9UER7
    Help top of page

    Additional Links

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