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Il10ra interleukin 10 receptor, alpha [ Mus musculus (house mouse) ]

Gene ID: 16154, updated on 17-May-2016
Official Symbol
Il10raprovided by MGI
Official Full Name
interleukin 10 receptor, alphaprovided by MGI
Primary source
MGI:MGI:96538
See related
Ensembl:ENSMUSG00000032089 Vega:OTTMUSG00000042168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Il10r; CDw210; CDw210a; IL-10R1; IL-10RA; mIL-10R; AW553859
Orthologs
Location:
9 A5.2; 9 24.84 cM
Exon count:
7
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (45253837..45269251, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (45061922..45077229, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39327 Neighboring gene transmembrane protease, serine 4 Neighboring gene cDNA sequence BC049352 Neighboring gene microRNA 7086 Neighboring gene RIKEN cDNA 1700003G13 gene Neighboring gene transmembrane protease, serine 13 Neighboring gene FXYD domain-containing ion transport regulator 6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
    Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • Epstein-Barr virus infection, conserved biosystem (from KEGG)
    Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Toxoplasmosis, organism-specific biosystem (from KEGG)
    Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Toxoplasmosis, conserved biosystem (from KEGG)
    Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
interleukin-10 binding ISO
Inferred from Sequence Orthology
more info
 
interleukin-10 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
interleukin-10 receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of synapse organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
interleukin-10 receptor subunit alpha
Names
IL-10 receptor subunit alpha
IL-10R subunit 1
IL-10R subunit alpha
interleukin-10 receptor subunit 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324486.1NP_001311415.1  interleukin-10 receptor subunit alpha isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice donor site in the 5' coding region, compared to variant 1. This difference results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AK149680, AK149899, AK153120, BY691362
  2. NM_008348.3NP_032374.1  interleukin-10 receptor subunit alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_032374.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK149899, AK159566, BY691362
    Consensus CDS
    CCDS23131.1
    UniProtKB/Swiss-Prot
    Q61727
    UniProtKB/TrEMBL
    Q3U6I9, Q3UDL4
    Related
    ENSMUSP00000034594, OTTMUSP00000061774, ENSMUST00000034594, OTTMUST00000110675
    Conserved Domains (2) summary
    pfam01108
    Location:4114
    Tissue_fac; Tissue factor
    cl21522
    Location:133225
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. NR_136903.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate 5' internal exon, compared to variant 1. This variant is represented as non-coding because the use of the translational start codon used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This transcript is potentially protein coding if an alternate upstream translational start codon is used.
    Source sequence(s)
    AK149899, AK153120, BY691362

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

    Range
    45253837..45269251 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242400.1XP_011240702.1  

    Conserved Domains (1) summary
    cl21522
    Location:2980
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Alternate Mm_Celera

Genomic

  1. AC_000031.1 Alternate Mm_Celera

    Range
    42530039..42545574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)