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Ikbkg inhibitor of kappaB kinase gamma [ Mus musculus (house mouse) ]

Gene ID: 16151, updated on 23-Apr-2016
Official Symbol
Ikbkgprovided by MGI
Official Full Name
inhibitor of kappaB kinase gammaprovided by MGI
Primary source
MGI:MGI:1338074
See related
Ensembl:ENSMUSG00000004221 Vega:OTTMUSG00000017732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NEMO; IKK[g]; AI848108; AI851264; AW124339; 1110037D23Rik
Orthologs
Location:
X; X A7.3
Exon count:
16
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) X NC_000086.7 (74393291..74456792)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (71638630..71699117)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene predicted readthrough transcript (NMD candidate), 44504 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 3 Neighboring gene family with sequence similarity 3, member A Neighboring gene glucose-6-phosphate dehydrogenase X-linked Neighboring gene predicted gene, 32472 Neighboring gene predicted gene 6880

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Chemically induced (ENU) (1) 
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  • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
    Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
  • Acute myeloid leukemia, conserved biosystem (from KEGG)
    Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
  • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
    Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
    Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Apoptosis, organism-specific biosystem (from WikiPathways)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Apoptosis, organism-specific biosystem (from KEGG)
    Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis, conserved biosystem (from KEGG)
    Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis signaling pathway, organism-specific biosystem (from LIPID MAPS)
    Apoptosis signaling pathway, organism-specific biosystem
    Apoptosis signaling pathway
  • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ???? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation...
  • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
    B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
  • B cell receptor signaling pathway, conserved biosystem (from KEGG)
    B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
  • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, organism-specific biosystem (from WikiPathways)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, conserved biosystem (from KEGG)
    Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
    Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
  • Chronic myeloid leukemia, conserved biosystem (from KEGG)
    Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
  • Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
    Cytosolic DNA-sensing pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
  • Cytosolic DNA-sensing pathway, conserved biosystem (from KEGG)
    Cytosolic DNA-sensing pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
  • EBV LMP1 signaling, organism-specific biosystem (from WikiPathways)
    EBV LMP1 signaling, organism-specific biosystembased on science-slides...
  • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
    Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • Epstein-Barr virus infection, conserved biosystem (from KEGG)
    Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Hepatitis B, organism-specific biosystem (from KEGG)
    Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
  • Hepatitis C, organism-specific biosystem (from KEGG)
    Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Hepatitis C, conserved biosystem (from KEGG)
    Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
    Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
    MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted inter...
  • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
    NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • NLR proteins, organism-specific biosystem (from WikiPathways)
    NLR proteins, organism-specific biosystemMammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen-associated-molecular- patterns (PAMP...
  • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
    NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K/Akt/mTOR signaling pathway, organism-specific biosystem (from LIPID MAPS)
    PI3K/Akt/mTOR signaling pathway, organism-specific biosystem
    PI3K/Akt/mTOR signaling pathway
  • Pancreatic cancer, organism-specific biosystem (from KEGG)
    Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
  • Pancreatic cancer, conserved biosystem (from KEGG)
    Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Primary immunodeficiency, organism-specific biosystem (from KEGG)
    Primary immunodeficiency, organism-specific biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
  • Primary immunodeficiency, conserved biosystem (from KEGG)
    Primary immunodeficiency, conserved biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
  • Prostate cancer, organism-specific biosystem (from KEGG)
    Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
  • Prostate cancer, conserved biosystem (from KEGG)
    Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
  • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
  • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
    RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Small cell lung cancer, organism-specific biosystem (from KEGG)
    Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • Small cell lung cancer, conserved biosystem (from KEGG)
    Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
  • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
    T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
  • T cell receptor signaling pathway, conserved biosystem (from KEGG)
    T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
  • TLR4 (Toll-like receptor 4) signaling pathway, organism-specific biosystem (from LIPID MAPS)
    TLR4 (Toll-like receptor 4) signaling pathway, organism-specific biosystem
    TLR4 (Toll-like receptor 4) signaling pathway
  • TNF signaling pathway, organism-specific biosystem (from KEGG)
    TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
  • TNF signaling pathway, conserved biosystem (from KEGG)
    TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
  • TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem
    TNF-alpha NF-kB Signaling Pathway
  • Toll Like Receptor signaling, organism-specific biosystem (from WikiPathways)
    Toll Like Receptor signaling, organism-specific biosystem
    Toll Like Receptor signaling
  • Toll-like receptor signaling, organism-specific biosystem (from KEGG)
    Toll-like receptor signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Toll-like receptor signaling, conserved biosystem (from KEGG)
    Toll-like receptor signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
    Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toxoplasmosis, organism-specific biosystem (from KEGG)
    Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Toxoplasmosis, conserved biosystem (from KEGG)
    Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • estrogen signalling, organism-specific biosystem (from WikiPathways)
    estrogen signalling, organism-specific biosystemEstrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear h...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
K63-linked polyubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
linear polyubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
peroxisome proliferator activated receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
IkappaB kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
IkappaB kinase complex ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
spindle pole ISO
Inferred from Sequence Orthology
more info
 
ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
NF-kappa-B essential modulator
Names
I-kappa-B kinase subunit gamma
IKK-gamma
IKKAP1
IKKG
NF-kappa-B essential modifier
ikB kinase subunit gamma
ikB kinase-associated protein 1
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
inhibitor of nuclear factor kappa-B kinase subunit gamma
mFIP-3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136067.2NP_001129539.1  NF-kappa-B essential modulator isoform 3

    See identical proteins and their annotated locations for NP_001129539.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AL669976, AY112937
    Consensus CDS
    CCDS53108.1
    UniProtKB/TrEMBL
    Q7TSS3
    Related
    ENSMUSP00000004330, ENSMUST00000004330
    Conserved Domains (2) summary
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:269355
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  2. NM_001161421.1NP_001154893.1  NF-kappa-B essential modulator isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (4) has the same N- and C-termini but is 1 aa shorter compared to isoform 3.
    Source sequence(s)
    AK037020, AL669976, AY112937
    UniProtKB/TrEMBL
    Q7TSS3, Q8VC91
    Conserved Domains (2) summary
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:268354
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  3. NM_001161422.1NP_001154894.1  NF-kappa-B essential modulator isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AL669976, AY112937, CN701499
    Consensus CDS
    CCDS53109.1
    UniProtKB/TrEMBL
    E9Q2Y3, Q7TSS3
    Related
    ENSMUSP00000109765, ENSMUST00000114130
    Conserved Domains (2) summary
    pfam11577
    Location:56123
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:263349
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  4. NM_001161423.1NP_001154895.1  NF-kappa-B essential modulator isoform 1

    See identical proteins and their annotated locations for NP_001154895.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. Variants 1 and 6 both encode the same isoform.
    Source sequence(s)
    AK037020, AL669976, CJ099503, CN717929
    Consensus CDS
    CCDS41023.1
    UniProtKB/Swiss-Prot
    O88522
    UniProtKB/TrEMBL
    Q8VC91
    Related
    ENSMUSP00000126770, ENSMUST00000164101
    Conserved Domains (2) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  5. NM_001161424.1NP_001154896.1  NF-kappa-B essential modulator isoform 2

    See identical proteins and their annotated locations for NP_001154896.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an internal aa compared to isoform 3. Variants 2 and 7 both encode the same isoform.
    Source sequence(s)
    AK037020, AL669976, CJ099503, CV556906
    Consensus CDS
    CCDS30233.1
    UniProtKB/TrEMBL
    Q8VC91
    Related
    ENSMUSP00000136573, ENSMUST00000180230
    Conserved Domains (2) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:250336
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  6. NM_010547.2NP_034677.2  NF-kappa-B essential modulator isoform 1

    See identical proteins and their annotated locations for NP_034677.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. Variants 1 and 6 both encode the same isoform.
    Source sequence(s)
    AL669976, AY112937, BY768708
    Consensus CDS
    CCDS41023.1
    UniProtKB/Swiss-Prot
    O88522
    UniProtKB/TrEMBL
    Q7TSS3
    Related
    ENSMUSP00000109762, OTTMUSP00000021360, ENSMUST00000114127, OTTMUST00000047324
    Conserved Domains (2) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  7. NM_178590.4NP_848705.1  NF-kappa-B essential modulator isoform 2

    See identical proteins and their annotated locations for NP_848705.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an internal aa compared to isoform 3. Variants 2 and 7 both encode the same isoform.
    Source sequence(s)
    AK037020, AL669976, BY768708
    Consensus CDS
    CCDS30233.1
    UniProtKB/TrEMBL
    Q8VC91
    Related
    ENSMUSP00000064017, OTTMUSP00000021361, ENSMUST00000064407, OTTMUST00000047325
    Conserved Domains (2) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:250336
    UBAN; polyubiquitin binding domain of NEMO and related proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p3 C57BL/6J

    Range
    74393291..74456792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527852.2XP_006527915.1  

    See identical proteins and their annotated locations for XP_006527915.1

    UniProtKB/Swiss-Prot
    O88522
    Conserved Domains (2) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  2. XM_006527848.2XP_006527911.1  

    See identical proteins and their annotated locations for XP_006527911.1

    UniProtKB/TrEMBL
    Q7TSS3
    Conserved Domains (2) summary
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:269355
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  3. XM_006527847.2XP_006527910.1  

    See identical proteins and their annotated locations for XP_006527910.1

    UniProtKB/TrEMBL
    Q7TSS3
    Conserved Domains (2) summary
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:269355
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  4. XM_006527853.2XP_006527916.1  

    See identical proteins and their annotated locations for XP_006527916.1

    UniProtKB/TrEMBL
    Q8VC91
    Related
    ENSMUSP00000109764, OTTMUSP00000021357, ENSMUST00000114129, OTTMUST00000047321
    Conserved Domains (2) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:250336
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  5. XM_006527850.2XP_006527913.1  

    See identical proteins and their annotated locations for XP_006527913.1

    UniProtKB/Swiss-Prot
    O88522
    Related
    ENSMUSP00000109763, OTTMUSP00000021358, ENSMUST00000114128, OTTMUST00000047322
    Conserved Domains (2) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  6. XM_006527851.2XP_006527914.1  

    See identical proteins and their annotated locations for XP_006527914.1

    UniProtKB/Swiss-Prot
    O88522
    Conserved Domains (2) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  7. XM_006527849.2XP_006527912.1  

    Conserved Domains (2) summary
    pfam11577
    Location:50117
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:257343
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  8. XM_011247527.1XP_011245829.1  

    See identical proteins and their annotated locations for XP_011245829.1

    UniProtKB/Swiss-Prot
    O88522
    Conserved Domains (2) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins

Alternate Mm_Celera

Genomic

  1. AC_000042.1 Alternate Mm_Celera

    Range
    65647484..65706592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)