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    Ikbkg inhibitor of kappaB kinase gamma [ Mus musculus (house mouse) ]

    Gene ID: 16151, updated on 18-May-2013
    Official Symbol
    Ikbkgprovided by MGI
    Official Full Name
    inhibitor of kappaB kinase gammaprovided by MGI
    Primary source
    MGI:1338074
    Locus tag
    RP23-15J3.1
    See related
    Ensembl:ENSMUSG00000004221; Vega:OTTMUSG00000017732
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NEMO; IKK[g]; AI848108; AI851264; AW124339; 1110037D23Rik
    Location :
    X A7.3; X
    Sequence :
    Chromosome: X; NC_000086.7 (74393291..74453778)
    See Ikbkg in Epigenomics, MapViewer

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 3 Neighboring gene family with sequence similarity 3, member A Neighboring gene glucose-6-phosphate dehydrogenase X-linked Neighboring gene predicted gene 6880 Neighboring gene ribosomal protein S2 pseudogene

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO. Müller-Rischart AK, et al. Mol Cell, 2013 Mar 7. PMID 23453807.
    2. NEMO binds ubiquitinated TANK-binding kinase 1 (TBK1) to regulate innate immune responses to RNA viruses. Wang L, et al. PLoS One, 2012. PMID 23028469.
    3. Intrinsic proinflammatory signaling in podocytes contributes to podocyte damage and prolonged proteinuria. Brähler S, et al. Am J Physiol Renal Physiol, 2012 Nov 15. PMID 22975019.
    4. NF-κB essential modifier is required for hepatocyte proliferation and the oval cell reaction after partial hepatectomy in mice. Malato Y, et al. Gastroenterology, 2012 Dec. PMID 22922425.
    5. Fluorescence-based sensors to monitor localization and functions of linear and K63-linked ubiquitin chains in cells. van Wijk SJ, et al. Mol Cell, 2012 Sep 14. PMID 22819327.

    See all (144) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO
      Title: The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO.
    2. In livers of mice, expression of NEMO and activation of NF-kappaB are required for hepatocyte proliferation and liver regeneration.
      Title: NF-κB essential modifier is required for hepatocyte proliferation and the oval cell reaction after partial hepatectomy in mice.
    3. NEMO binds ubiquitinated TANK-binding kinase 1 (TBK1) to regulate innate immune responses to RNA viruses.
      Title: NEMO binds ubiquitinated TANK-binding kinase 1 (TBK1) to regulate innate immune responses to RNA viruses.
    4. Data show that NEMO forms a complex with IKKbeta and IkappaBalpha.
      Title: NEMO ensures signaling specificity of the pleiotropic IKKβ by directing its kinase activity toward IκBα.
    5. Murine cytomegalovirus inhibits the inflammatory cascade by blocking Toll-like receptor and IL-1 receptor-dependent NF-kappaB activation through an interaction of the viral M45 protein with the NF-kappaB essential modulator.
      Title: Viral mediated redirection of NEMO/IKKγ to autophagosomes curtails the inflammatory cascade.
    6. When peptides containing the NF-kappaB essential modulator (NEMO) binding domain disrupt the IkappaB kinase (IKK)gamma complex, NF-kappaB activation is blocked, necrosis is decreased and regeneration is increased.
      Title: Systemic delivery of NEMO binding domain/IKKγ inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology.
    7. NEMO Lysine392, a well-established K63-linked polyubiquitination site, is an important mediator of polymethylmethacrylate-induced osteolysis.
      Title: Lysine392, a K63-linked ubiquitination site in NEMO, mediates inflammatory osteoclastogenesis and osteolysis.
    8. tumor necrosis factor alpha-induced necroptosis requires the adaptor proteins FADD and NEMO.
      Title: Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis.
    9. Data show that DNA damage stimulates the formation of a cytosolic complex of ATM, NEMO, RIP1, and TAK1, and that TAK1 mediates the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage.
      Title: A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage.
    10. ANXA1 can constitutively activate NF-kappaB in breast cancer cells through the interaction with the IKK complex
      Title: Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-κB: implication in breast cancer metastasis.
    Submit: New GeneRIF Correction See all (48)
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description
    NP_034677.1 NP_031726.1 Chuk    BIND  PubMed IKK-alpha interacts with IKK-gamma. This interaction was modelled on a demonstrated interaction between mouse IKK-alpha and human IKK-gamma. 
    BioGRID:200602 BioGRID:204251 Cd40    BioGRID  PubMed Affinity Capture-Western 
    NP_031726.1 Chuk    BIND  PubMed IKK-alpha interacts with IKK-gamma. 
    BioGRID:200602 BioGRID:198709 Chuk    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200602 BioGRID:216612 Cyld    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200602 BioGRID:208115 Gsk3b    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200602 BioGRID:200452 Hspa1b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:200602 BioGRID:200601 Ikbkb    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:200602 BioGRID:200602 Ikbkg    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200602 BioGRID:222170 Maml1    BioGRID  PubMed Two-hybrid 
    BioGRID:200602 BioGRID:204955 Map3k1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200602 BioGRID:204962 Map3k7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200602 BioGRID:110859 NFKBIA    BioGRID  PubMed Biochemical Activity 
    BioGRID:200602 BioGRID:201709 Ncoa3    BioGRID  PubMed Two-hybrid 
    BioGRID:200602 BioGRID:201742 Nfe2    BioGRID  PubMed Two-hybrid 
    BioGRID:200602 BioGRID:201753 Nfkbia    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:200602 BioGRID:201754 Nfkbib    BioGRID  PubMed Biochemical Activity 
    BioGRID:200602 BioGRID:219820 Nfkbiz    BioGRID  PubMed Two-hybrid 
    BioGRID:200602 BioGRID:198300 Nkx3-2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200602 BioGRID:234769 Nlrx1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200602 BioGRID:204899 Rbck1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:200602 BioGRID:202896 Ripk1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200602 BioGRID:234548 Rnf31    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:200602 BioGRID:222977 Sharpin    BioGRID  PubMed Biochemical Activity 
    BioGRID:200602 BioGRID:115602 TNIP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:200602 BioGRID:115979 TRAF3IP2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:200602 BioGRID:204015 Tcf3    BioGRID  PubMed Two-hybrid 
    BioGRID:200602 BioGRID:204224 Tlr4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200602 BioGRID:204243 Tnfaip3    BioGRID  PubMed Two-hybrid 
    BioGRID:200602 BioGRID:204249 Tnfrsf1a    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200602 BioGRID:204303 Traf2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200602 BioGRID:204307 Traf6    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:200602 BioGRID:204341 Tsg101    BioGRID  PubMed Two-hybrid 
    BioGRID:200602 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure 
    BioGRID:200602 BioGRID:204403 Ubc    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:200602 BioGRID:220301 Ube2n    BioGRID  PubMed Affinity Capture-Western 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    B cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    activation of NF-kappaB-inducing kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    IkappaB kinase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    cytoplasmic part ISO
    Inferred from Sequence Orthology
    more info
    		  
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    intracellular ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Preferred Names
    NF-kappa-B essential modulator
    Names
    NF-kappa-B essential modulator
    IKKG
    IKKAP1
    mFIP-3
    IKK-gamma
    ikB kinase subunit gamma
    NF-kappa-B essential modifier
    I-kappa-B kinase subunit gamma
    ikB kinase-associated protein 1
    inhibitor of nuclear factor kappa-B kinase subunit gamma
    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136067.2 → NP_001129539.1  NF-kappa-B essential modulator isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AL669976, AY112937
      Consensus CDS
      CCDS53108.1
      UniProtKB/TrEMBL
      Q7TSS3
      Related
      ENSMUSP00000004330, ENSMUST00000004330
      Conserved Domains (2) summary
      pfam11577
      Location:62 – 129
      Blast Score: 199
      NEMO; NF-kappa-B essential modulator NEMO
      cd09803
      Location:292 – 330
      Blast Score: 129
      UBAN; polyubiquitin binding domain of NEMO and related proteins

    2. NM_001161421.1 → NP_001154893.1  NF-kappa-B essential modulator isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (4) has the same N- and C-termini but is 1 aa shorter compared to isoform 3.
      Source sequence(s)
      AK037020, AL669976, AY112937
      UniProtKB/TrEMBL
      Q7TSS3
      UniProtKB/TrEMBL
      Q8VC91
      Conserved Domains (2) summary
      pfam11577
      Location:62 – 129
      Blast Score: 193
      NEMO; NF-kappa-B essential modulator NEMO
      cd09803
      Location:291 – 329
      Blast Score: 125
      UBAN; polyubiquitin binding domain of NEMO and related proteins

    3. NM_001161422.1 → NP_001154894.1  NF-kappa-B essential modulator isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 3.
      Source sequence(s)
      AL669976, AY112937, CN701499
      Consensus CDS
      CCDS53109.1
      UniProtKB/TrEMBL
      E9Q2Y3
      UniProtKB/TrEMBL
      Q7TSS3
      Related
      ENSMUSP00000109765, ENSMUST00000114130
      Conserved Domains (2) summary
      pfam11577
      Location:56 – 123
      Blast Score: 195
      NEMO; NF-kappa-B essential modulator NEMO
      cd09803
      Location:286 – 324
      Blast Score: 129
      UBAN; polyubiquitin binding domain of NEMO and related proteins

    4. NM_001161423.1 → NP_001154895.1  NF-kappa-B essential modulator isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. Variants 1 and 6 both encode the same isoform.
      Source sequence(s)
      AK037020, AL669976, CJ099503, CN717929
      Consensus CDS
      CCDS41023.1
      UniProtKB/Swiss-Prot
      O88522
      UniProtKB/TrEMBL
      Q8VC91
      Related
      ENSMUSP00000126770, ENSMUST00000164101
      Conserved Domains (2) summary
      pfam11577
      Location:44 – 111
      Blast Score: 193
      NEMO; NF-kappa-B essential modulator NEMO
      cd09803
      Location:274 – 312
      Blast Score: 126
      UBAN; polyubiquitin binding domain of NEMO and related proteins

    5. NM_001161424.1 → NP_001154896.1  NF-kappa-B essential modulator isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an internal aa compared to isoform 3. Variants 2 and 7 both encode the same isoform.
      Source sequence(s)
      AK037020, AL669976, CJ099503, CV556906
      Consensus CDS
      CCDS30233.1
      UniProtKB/TrEMBL
      Q8VC91
      Related
      ENSMUSP00000136573, ENSMUST00000180230
      Conserved Domains (2) summary
      pfam11577
      Location:44 – 111
      Blast Score: 187
      NEMO; NF-kappa-B essential modulator NEMO
      cd09803
      Location:273 – 311
      Blast Score: 122
      UBAN; polyubiquitin binding domain of NEMO and related proteins

    6. NM_010547.2 → NP_034677.2  NF-kappa-B essential modulator isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. Variants 1 and 6 both encode the same isoform.
      Source sequence(s)
      AL669976, AY112937, BY768708
      Consensus CDS
      CCDS41023.1
      UniProtKB/Swiss-Prot
      O88522
      UniProtKB/TrEMBL
      Q7TSS3
      Conserved Domains (2) summary
      pfam11577
      Location:44 – 111
      Blast Score: 193
      NEMO; NF-kappa-B essential modulator NEMO
      cd09803
      Location:274 – 312
      Blast Score: 126
      UBAN; polyubiquitin binding domain of NEMO and related proteins

    7. NM_178590.4 → NP_848705.1  NF-kappa-B essential modulator isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an internal aa compared to isoform 3. Variants 2 and 7 both encode the same isoform.
      Source sequence(s)
      AK037020, AL669976, BY768708
      Consensus CDS
      CCDS30233.1
      UniProtKB/TrEMBL
      Q8VC91
      Conserved Domains (2) summary
      pfam11577
      Location:44 – 111
      Blast Score: 187
      NEMO; NF-kappa-B essential modulator NEMO
      cd09803
      Location:273 – 311
      Blast Score: 122
      UBAN; polyubiquitin binding domain of NEMO and related proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p1 C57BL/6J

      Range
      74393291..74453778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000042.1 Alternate Mm_Celera

      Range
      65647484..65706592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01212730.1 None
    genomic AAHY01212731.1 (25818..33909) None
    genomic AC091474.2 (130752..152574) None
    genomic AF326207.1 AAK69186.1
    genomic AL669976.11 (6..32981) None
    genomic AL807376.4 (175677..203189) None
    genomic CH466650.2 EDL29809.1 mixed
      EDL29810.1 mixed
    mRNA AF069542.1 AAC40153.1
    mRNA AF513109.1 AAP47160.1 BALB/c
    mRNA AK037020.1 BAC29672.1 C57BL/6J
    mRNA AK042138.1 None C57BL/6J
    mRNA AK047400.1 None C57BL/6J
    mRNA AK048446.1 None C57BL/6J
    mRNA AK148163.1 BAE28385.1 C57BL/6J
    mRNA AK154095.1 BAE32372.1 NOD
    mRNA AK188269.1 None
    mRNA AY112937.1 AAM54725.1 C57BL/6
    mRNA BC021431.1 AAH21431.1
    mRNA BC026905.1 None FVB/N
    mRNA BY768708.1 None C57BL/6J
    mRNA CJ099503.1 None C57BL/6J
    mRNA CN701499.1 None C57BL/6J
    mRNA CN717929.1 None C57BL/6J
    mRNA CV556906.1 None C57BL/6
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88522.2 GenPept UniProtKB/Swiss-Prot:O88522

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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