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Ikbkg inhibitor of kappaB kinase gamma [ Mus musculus (house mouse) ]

Gene ID: 16151, updated on 15-Nov-2014
Official Symbol
Ikbkgprovided by MGI
Official Full Name
inhibitor of kappaB kinase gammaprovided by MGI
Primary source
MGI:MGI:1338074
Locus tag
RP23-15J3.1
See related
Ensembl:ENSMUSG00000004221; Vega:OTTMUSG00000017732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NEMO; IKK[g]; AI848108; AI851264; AW124339; 1110037D23Rik
See Ikbkg in Epigenomics, MapViewer
Location:
X A7.3; X
Exon count:
15
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) X NC_000086.7 (74393291..74453778)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene Slc10a3-Ubl4 readthrough Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 3 Neighboring gene family with sequence similarity 3, member A Neighboring gene glucose-6-phosphate dehydrogenase X-linked Neighboring gene predicted gene, 32472 Neighboring gene predicted gene 6880

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Chemically induced (ENU) (1) 
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
K63-linked polyubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
linear polyubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
peroxisome proliferator activated receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
IkappaB kinase complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
NF-kappa-B essential modulator
Names
NF-kappa-B essential modulator
IKKG
IKKAP1
mFIP-3
IKK-gamma
ikB kinase subunit gamma
NF-kappa-B essential modifier
I-kappa-B kinase subunit gamma
ikB kinase-associated protein 1
inhibitor of nuclear factor kappa-B kinase subunit gamma
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136067.2NP_001129539.1  NF-kappa-B essential modulator isoform 3

    See proteins identical to NP_001129539.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AL669976, AY112937
    Consensus CDS
    CCDS53108.1
    UniProtKB/TrEMBL
    Q7TSS3
    Related
    ENSMUSP00000004330, ENSMUST00000004330
    Conserved Domains (3) summary
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:269355
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19113
    Location:135250
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  2. NM_001161421.1NP_001154893.1  NF-kappa-B essential modulator isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (4) has the same N- and C-termini but is 1 aa shorter compared to isoform 3.
    Source sequence(s)
    AK037020, AL669976, AY112937
    UniProtKB/TrEMBL
    Q7TSS3
    UniProtKB/TrEMBL
    Q8VC91
    Conserved Domains (3) summary
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:268354
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19113
    Location:135249
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  3. NM_001161422.1NP_001154894.1  NF-kappa-B essential modulator isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 3.
    Source sequence(s)
    AL669976, AY112937, CN701499
    Consensus CDS
    CCDS53109.1
    UniProtKB/TrEMBL
    E9Q2Y3
    UniProtKB/TrEMBL
    Q7TSS3
    Related
    ENSMUSP00000109765, ENSMUST00000114130
    Conserved Domains (3) summary
    pfam11577
    Location:56123
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:263349
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19113
    Location:129244
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  4. NM_001161423.1NP_001154895.1  NF-kappa-B essential modulator isoform 1

    See proteins identical to NP_001154895.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. Variants 1 and 6 both encode the same isoform.
    Source sequence(s)
    AK037020, AL669976, CJ099503, CN717929
    Consensus CDS
    CCDS41023.1
    UniProtKB/Swiss-Prot
    O88522
    UniProtKB/TrEMBL
    Q8VC91
    Related
    ENSMUSP00000126770, ENSMUST00000164101
    Conserved Domains (3) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19113
    Location:117232
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  5. NM_001161424.1NP_001154896.1  NF-kappa-B essential modulator isoform 2

    See proteins identical to NP_001154896.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an internal aa compared to isoform 3. Variants 2 and 7 both encode the same isoform.
    Source sequence(s)
    AK037020, AL669976, CJ099503, CV556906
    Consensus CDS
    CCDS30233.1
    UniProtKB/TrEMBL
    Q8VC91
    Related
    ENSMUSP00000136573, ENSMUST00000180230
    Conserved Domains (3) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:250336
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19113
    Location:117231
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  6. NM_010547.2NP_034677.2  NF-kappa-B essential modulator isoform 1

    See proteins identical to NP_034677.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. Variants 1 and 6 both encode the same isoform.
    Source sequence(s)
    AL669976, AY112937, BY768708
    Consensus CDS
    CCDS41023.1
    UniProtKB/Swiss-Prot
    O88522
    UniProtKB/TrEMBL
    Q7TSS3
    Conserved Domains (3) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19113
    Location:117232
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  7. NM_178590.4NP_848705.1  NF-kappa-B essential modulator isoform 2

    See proteins identical to NP_848705.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an internal aa compared to isoform 3. Variants 2 and 7 both encode the same isoform.
    Source sequence(s)
    AK037020, AL669976, BY768708
    Consensus CDS
    CCDS30233.1
    UniProtKB/TrEMBL
    Q8VC91
    Conserved Domains (3) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:250336
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19113
    Location:117231
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000086.7 

    Range
    74393291..74453778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527852.1XP_006527915.1  

    See proteins identical to XP_006527915.1

    UniProtKB/Swiss-Prot
    O88522
    Related
    ENSMUSP00000064017, OTTMUSP00000021361, ENSMUST00000064407, OTTMUST00000047325
    Conserved Domains (3) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19113
    Location:117232
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  2. XM_006527848.1XP_006527911.1  

    See proteins identical to XP_006527911.1

    UniProtKB/TrEMBL
    Q7TSS3
    Conserved Domains (3) summary
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:269355
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19113
    Location:135250
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  3. XM_006527853.1XP_006527916.1  

    See proteins identical to XP_006527916.1

    UniProtKB/TrEMBL
    Q8VC91
    Conserved Domains (3) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:250336
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19113
    Location:117231
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  4. XM_006527847.1XP_006527910.1  

    See proteins identical to XP_006527910.1

    UniProtKB/TrEMBL
    Q7TSS3
    Conserved Domains (3) summary
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:269355
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19113
    Location:135250
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  5. XM_006527850.1XP_006527913.1  

    See proteins identical to XP_006527913.1

    UniProtKB/Swiss-Prot
    O88522
    Related
    ENSMUSP00000109768, OTTMUSP00000019310, ENSMUST00000114133, OTTMUST00000042945
    Conserved Domains (3) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19113
    Location:117232
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  6. XM_006527851.1XP_006527914.1  

    See proteins identical to XP_006527914.1

    UniProtKB/Swiss-Prot
    O88522
    Conserved Domains (3) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19113
    Location:117232
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  7. XM_006527849.1XP_006527912.1  

    Conserved Domains (3) summary
    pfam11577
    Location:50117
    NEMO; NF-kappa-B essential modulator NEMO
    cd09803
    Location:257343
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19113
    Location:123238
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

Alternate Mm_Celera

Genomic

  1. AC_000042.1 

    Range
    65647484..65706592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)