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    Ikbkg inhibitor of kappaB kinase gamma [ Mus musculus ]

    Gene ID: 16151, updated on 19-May-2012
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    Summary

    Official Symbol
    Ikbkgprovided by MGI
    Official Full Name
    inhibitor of kappaB kinase gammaprovided by MGI
    Primary source
    MGI:1338074
    Locus tag
    RP23-15J3.1
    See related
    Ensembl:ENSMUSG00000004221; Vega:OTTMUSG00000017732
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NEMO; IKK[g]; AI848108; AI851264; AW124339; 1110037D23Rik
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    Genomic context

    Location :
    X A7.3; X
    Sequence :
    Chromosome: X; NC_000086.7 (74393291..74453778)
    See Ikbkg in Epigenomics, MapViewer

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 3 Neighboring gene family with sequence similarity 3, member A Neighboring gene glucose-6-phosphate dehydrogenase X-linked Neighboring gene predicted gene 6880 Neighboring gene ribosomal protein S2 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The MC159 protein from the molluscum contagiosum poxvirus inhibits NF-κB activation by interacting with the IκB kinase complex. Randall CM, et al. J Immunol, 2012 Mar 1. PMID 22301546.
    2. Lysine392, a K63-linked ubiquitination site in NEMO, mediates inflammatory osteoclastogenesis and osteolysis. Alhawagri M, et al. J Orthop Res, 2012 Apr. PMID 21913221.
    3. FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Welz PS, et al. Nature, 2011 Jul 31. PMID 21804564.
    4. Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis. Irrinki KM, et al. Mol Cell Biol, 2011 Sep. PMID 21746883.
    5. NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK. Xia X, et al. Immunity, 2011 Jun 24. PMID 21703539.

    See all (120) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. NEMO Lysine392, a well-established K63-linked polyubiquitination site, is an important mediator of polymethylmethacrylate-induced osteolysis.
      Title: Lysine392, a K63-linked ubiquitination site in NEMO, mediates inflammatory osteoclastogenesis and osteolysis.
    2. tumor necrosis factor alpha-induced necroptosis requires the adaptor proteins FADD and NEMO.
      Title: Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis.
    3. Data show that DNA damage stimulates the formation of a cytosolic complex of ATM, NEMO, RIP1, and TAK1, and that TAK1 mediates the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage.
      Title: A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage.
    4. ANXA1 can constitutively activate NF-kappaB in breast cancer cells through the interaction with the IKK complex
      Title: Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-κB: implication in breast cancer metastasis.
    5. the effects of individually deleting the NEMO-binding domains in IKK alpha and IKK beta on classical NF-kappa B signaling and IKK complex formation.
      Title: NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation.
    6. binding of linear ubiquitin chains to NEMO in NF-kappaB activation
      Title: Selective binding of linear ubiquitin chains to NEMO in NF-kappaB activation.
    7. PAD2 interacts with IKKgamma and suppresses NF-kappaB activity.
      Title: Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages.
    8. ATM- and NEMO-dependent ubiquitination of ELKS leads to the ubiquitin-dependent assembly of TAK1/TAB2/3 and NEMO/IKK complexes, resulting in IKK and NF-kappaB activation following genotoxic stimuli.
      Title: ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.
    9. RNAi down-regulation of the expression of IKKalpha and IKKgamma also down-regulated the expression of NF-KappaB p65, p50 and p105 proteins both in cytoplasm and nucleus.
      Title: [Influence of inhibitory KappaB protein kinase alpha and gamma genes silencing induced by RNA interference on nuclear factor-KappaB signal pathway].
    10. A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha.
      Title: A mutation of Ikbkg causes immune deficiency without impairing degradation of IkappaB alpha.
    Submit: New GeneRIF Correction See all (42)
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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_034677.1 NP_031726.1 Chuk    BIND  PubMed IKK-alpha interacts with IKK-gamma. This interaction was modelled on a demonstrated interaction between mouse IKK-alpha and human IKK-gamma. 
    BioGRID:200602 BioGRID:204251 Cd40    BioGRID  PubMed Affinity Capture-Western 
    NP_031726.1 Chuk    BIND  PubMed IKK-alpha interacts with IKK-gamma. 
    BioGRID:200602 BioGRID:200452 Hspa1b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:200602 BioGRID:200601 Ikbkb    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:200602 BioGRID:222170 Maml1    BioGRID  PubMed Two-hybrid 
    BioGRID:200602 BioGRID:204955 Map3k1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200602 BioGRID:204962 Map3k7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200602 BioGRID:201709 Ncoa3    BioGRID  PubMed Two-hybrid 
    BioGRID:200602 BioGRID:201742 Nfe2    BioGRID  PubMed Two-hybrid 
    BioGRID:200602 BioGRID:219820 Nfkbiz    BioGRID  PubMed Two-hybrid 
    BioGRID:200602 BioGRID:198300 Nkx3-2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200602 BioGRID:234769 Nlrx1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200602 BioGRID:204899 Rbck1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:200602 BioGRID:202896 Ripk1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200602 BioGRID:234548 Rnf31    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:200602 BioGRID:222977 Sharpin    BioGRID  PubMed Biochemical Activity 
    BioGRID:200602 BioGRID:115602 TNIP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:200602 BioGRID:115979 TRAF3IP2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:200602 BioGRID:204015 Tcf3    BioGRID  PubMed Two-hybrid 
    BioGRID:200602 BioGRID:204224 Tlr4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200602 BioGRID:204243 Tnfaip3    BioGRID  PubMed Two-hybrid 
    BioGRID:200602 BioGRID:204303 Traf2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200602 BioGRID:204307 Traf6    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:200602 BioGRID:204341 Tsg101    BioGRID  PubMed Two-hybrid 
    BioGRID:200602 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure 
    BioGRID:200602 BioGRID:204403 Ubc    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:200602 BioGRID:220301 Ube2n    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    B cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    activation of NF-kappaB-inducing kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    IkappaB kinase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    cytoplasmic part ISO
    Inferred from Sequence Orthology
    more info
    		  
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
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    General protein information

    Preferred Names
    NF-kappa-B essential modulator
    Names
    NF-kappa-B essential modulator
    IKKG
    IKKAP1
    mFIP-3
    IKK-gamma
    ikB kinase subunit gamma
    NF-kappa-B essential modifier
    I-kappa-B kinase subunit gamma
    ikB kinase-associated protein 1
    inhibitor of nuclear factor kappa-B kinase subunit gamma
    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136067.2 → NP_001129539.1  NF-kappa-B essential modulator isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AL669976, AY112937
      Consensus CDS
      CCDS53108.1
      UniProtKB/TrEMBL
      Q7TSS3
      Related
      ENSMUSP00000004330, ENSMUST00000004330
      Conserved Domains (3) summary
      pfam11577
      Location:62 – 129
      Blast Score: 199
      NEMO; NF-kappa-B essential modulator NEMO
      TIGR02168
      Location:67 – 254
      Blast Score: 112
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd09803
      Location:292 – 330
      Blast Score: 129
      UBAN; polyubiquitin binding domain of NEMO and related proteins

    2. NM_001161421.1 → NP_001154893.1  NF-kappa-B essential modulator isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (4) has the same N- and C-termini but is 1 aa shorter compared to isoform 3.
      Source sequence(s)
      AK037020, AL669976, AY112937
      UniProtKB/TrEMBL
      A3KG33
      UniProtKB/TrEMBL
      Q7TSS3
      UniProtKB/TrEMBL
      Q8VC91
      Conserved Domains (3) summary
      pfam11577
      Location:62 – 129
      Blast Score: 193
      NEMO; NF-kappa-B essential modulator NEMO
      TIGR02168
      Location:67 – 253
      Blast Score: 147
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd09803
      Location:291 – 329
      Blast Score: 125
      UBAN; polyubiquitin binding domain of NEMO and related proteins

    3. NM_001161422.1 → NP_001154894.1  NF-kappa-B essential modulator isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 3.
      Source sequence(s)
      AL669976, AY112937, CN701499
      Consensus CDS
      CCDS53109.1
      UniProtKB/TrEMBL
      E9Q2Y3
      UniProtKB/TrEMBL
      Q7TSS3
      Related
      ENSMUSP00000109765, ENSMUST00000114130
      Conserved Domains (3) summary
      pfam11577
      Location:56 – 123
      Blast Score: 195
      NEMO; NF-kappa-B essential modulator NEMO
      TIGR02168
      Location:61 – 248
      Blast Score: 110
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd09803
      Location:286 – 324
      Blast Score: 129
      UBAN; polyubiquitin binding domain of NEMO and related proteins

    4. NM_001161423.1 → NP_001154895.1  NF-kappa-B essential modulator isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. Variants 1 and 6 both encode the same isoform.
      Source sequence(s)
      AK037020, AL669976, CJ099503, CN717929
      Consensus CDS
      CCDS41023.1
      UniProtKB/Swiss-Prot
      O88522
      UniProtKB/TrEMBL
      Q8VC91
      Related
      ENSMUSP00000126770, ENSMUST00000164101
      Conserved Domains (3) summary
      pfam11577
      Location:44 – 111
      Blast Score: 193
      NEMO; NF-kappa-B essential modulator NEMO
      TIGR02168
      Location:49 – 236
      Blast Score: 108
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd09803
      Location:274 – 312
      Blast Score: 126
      UBAN; polyubiquitin binding domain of NEMO and related proteins

    5. NM_001161424.1 → NP_001154896.1  NF-kappa-B essential modulator isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an internal aa compared to isoform 3. Variants 2 and 7 both encode the same isoform.
      Source sequence(s)
      AK037020, AL669976, CJ099503, CV556906
      Consensus CDS
      CCDS30233.1
      UniProtKB/TrEMBL
      Q8VC91
      Related
      ENSMUSP00000109764, OTTMUSP00000021357, ENSMUST00000114129, OTTMUST00000047321
      Conserved Domains (3) summary
      pfam11577
      Location:44 – 111
      Blast Score: 187
      NEMO; NF-kappa-B essential modulator NEMO
      TIGR02168
      Location:49 – 235
      Blast Score: 142
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd09803
      Location:273 – 311
      Blast Score: 122
      UBAN; polyubiquitin binding domain of NEMO and related proteins

    6. NM_010547.2 → NP_034677.2  NF-kappa-B essential modulator isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (1) is shorter at the N-terminus compared to isoform 3. Variants 1 and 6 both encode the same isoform.
      Source sequence(s)
      AL669976, AY112937, BY768708
      Consensus CDS
      CCDS41023.1
      UniProtKB/Swiss-Prot
      O88522
      UniProtKB/TrEMBL
      Q7TSS3
      Related
      ENSMUSP00000109762, OTTMUSP00000021360, ENSMUST00000114127, OTTMUST00000047324
      Conserved Domains (3) summary
      pfam11577
      Location:44 – 111
      Blast Score: 193
      NEMO; NF-kappa-B essential modulator NEMO
      TIGR02168
      Location:49 – 236
      Blast Score: 108
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd09803
      Location:274 – 312
      Blast Score: 126
      UBAN; polyubiquitin binding domain of NEMO and related proteins

    7. NM_178590.4 → NP_848705.1  NF-kappa-B essential modulator isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 3. The resulting isoform (2) is shorter at the N-terminus and lacks an internal aa compared to isoform 3. Variants 2 and 7 both encode the same isoform.
      Source sequence(s)
      AK037020, AL669976, BY768708
      Consensus CDS
      CCDS30233.1
      UniProtKB/TrEMBL
      Q8VC91
      Related
      ENSMUSP00000064017, OTTMUSP00000021361, ENSMUST00000064407, OTTMUST00000047325
      Conserved Domains (3) summary
      pfam11577
      Location:44 – 111
      Blast Score: 187
      NEMO; NF-kappa-B essential modulator NEMO
      TIGR02168
      Location:49 – 235
      Blast Score: 142
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd09803
      Location:273 – 311
      Blast Score: 122
      UBAN; polyubiquitin binding domain of NEMO and related proteins

    RefSeqs of Annotated Genomes: Build 38.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38 C57BL/6J

      Range
      74393291..74453778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000042.1 Alternate Mm_Celera

      Range
      65647484..65706592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AC091474.2 (130751..152573) None
    genomic AF326207.1 AAK69186.1
    genomic AL669976.11 CAM45961.1
      CAM45962.1
      CAM45963.1
      CAM45966.1
      CAM45967.1
      CAM45968.1
      CAM45969.1
      CAM45970.1
      CAM45971.1
      CAM45972.1
      CAM45973.1
    genomic AL807376.4 (175676..203188) None
    genomic CH466650.2 EDL29809.1 mixed
      EDL29810.1 mixed
    mRNA AF069542.1 AAC40153.1
    mRNA AF513109.1 AAP47160.1 BALB/c
    mRNA AK037020.1 BAC29672.1 C57BL/6J
    mRNA AK042138.1 None C57BL/6J
    mRNA AK047400.1 None C57BL/6J
    mRNA AK048446.1 None C57BL/6J
    mRNA AK148163.1 BAE28385.1 C57BL/6J
    mRNA AK154095.1 BAE32372.1 NOD
    mRNA AK188269.1 None
    mRNA AY112937.1 AAM54725.1 C57BL/6
    mRNA BC021431.1 AAH21431.1
    mRNA BC026905.1 None FVB/N
    mRNA BY768708.1 None C57BL/6J
    mRNA CJ099503.1 None C57BL/6J
    mRNA CN701499.1 None C57BL/6J
    mRNA CN717929.1 None C57BL/6J
    mRNA CV556906.1 None C57BL/6
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88522.2 GenPept UniProtKB/Swiss-Prot:O88522
    Q3UG24 GenPept UniProtKB/TrEMBL:Q3UG24
    Q7TSS3 GenPept UniProtKB/TrEMBL:Q7TSS3
    Q8VC91 GenPept UniProtKB/TrEMBL:Q8VC91
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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