Format

Send to:

Choose Destination

Ihh Indian hedgehog [ Mus musculus (house mouse) ]

Gene ID: 16147, updated on 28-May-2016
Official Symbol
Ihhprovided by MGI
Official Full Name
Indian hedgehogprovided by MGI
Primary source
MGI:MGI:96533
See related
Ensembl:ENSMUSG00000006538 Vega:OTTMUSG00000048255
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HHG-2
Orthologs
Location:
1 C3; 1 38.55 cM
Exon count:
3
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (74945318..74951651, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (74991892..74998225, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 108 Neighboring gene microRNA 375 Neighboring gene nonhomologous end-joining factor 1 Neighboring gene solute carrier family 23 (nucleobase transporters), member 3 Neighboring gene cyclin Pas1/PHO80 domain containing 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Potential readthrough

Included gene: Nhej1

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
patched binding IPI
Inferred from Physical Interaction
more info
PubMed 
patched binding ISO
Inferred from Sequence Orthology
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
bone resorption IDA
Inferred from Direct Assay
more info
PubMed 
camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
camera-type eye photoreceptor cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cartilage development ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-cell signaling IEA
Inferred from Electronic Annotation
more info
 
chondrocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic camera-type eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic digit morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic skeletal joint development IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
head morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
intein-mediated protein splicing IEA
Inferred from Electronic Annotation
more info
 
morphogenesis of a branching structure IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of eye pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of immature T cell proliferation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
 
neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
pancreas development IGI
Inferred from Genetic Interaction
more info
PubMed 
pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
patterning of blood vessels IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of collagen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
proteoglycan metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of growth IGI
Inferred from Genetic Interaction
more info
PubMed 
retinal pigment epithelium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal system development ISO
Inferred from Sequence Orthology
more info
 
smooth muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
somite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
vitelline membrane formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
proteinaceous extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313683.1NP_001300612.1  indian hedgehog protein isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) has a distinct, shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AC139023, AK090147, AK144322
    UniProtKB/TrEMBL
    Q80XI9
    Conserved Domains (1) summary
    pfam01085
    Location:44189
    HH_signal; Hedgehog amino-terminal signalling domain
  2. NM_010544.3NP_034674.2  indian hedgehog protein isoform 1 preproprotein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC139023, AI323361, AK144322
    Consensus CDS
    CCDS15061.1
    UniProtKB/Swiss-Prot
    P97812
    UniProtKB/TrEMBL
    Q80XI9
    Related
    ENSMUSP00000128056, OTTMUSP00000067528, ENSMUST00000164097, OTTMUST00000123861
    Conserved Domains (3) summary
    cd00081
    Location:203347
    Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
    pfam01079
    Location:192396
    Hint; Hint module
    pfam01085
    Location:44189
    HH_signal; Hedgehog amino-terminal signalling domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    74945318..74951651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    75500289..75506631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)