DAPK3 death-associated protein kinase 3 [Homo sapiens] - Gene

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Summary

Official Symbol: DAPK3provided by HGNC
Official Full Name: death-associated protein kinase 3provided by HGNC
Primary source: HGNC:2676
See related: Ensembl:ENSG00000167657; HPRD:04478; MIM:603289
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ZIP; ZIPK; FLJ36473
Summary: Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 19p13.3

Sequence :: Chromosome: 19; NC_000019.9 (3958452..3969826, complement)

See DAPK3 in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ZIPK may serve as a transcriptional regulator of canonical Wnt/beta-catenin signaling through interaction with NLK/TCF4.
Title: Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4).
Results suggest that DAPK3 is a tumor suppressor in which loss-of-function mutations promote increased cell survival, proliferation, cellular aggregation.
Title: Cancer-associated loss-of-function mutations implicate DAPK3 as a tumor-suppressing kinase.
The NLS2 of human ZIPK functions the nucleus-directing motif, but only upon dephosphorylation of the adjacent T299 residue.
Title: Phosphorylation-dependent control of ZIPK nuclear import is species specific.
Dlk plays a positive role in modulating death-related signaling pathways.
Title: Link of Dlk/ZIP kinase to cell apoptosis and tumor suppression.
ZIPK is a tumor suppresser gene and plays an important role in gastric carcinoma
Title: Downregulation of ZIP kinase is associated with tumor invasion, metastasis and poor prognosis in gastric cancer.
These results suggest that UbcH5 regulates ZIPK accumulation in PML-NBs by interacting with ZIPK and stimulating its ubiquitination.
Title: Physical and functional interactions between ZIP kinase and UbcH5.
ZIP kinase plays a crucial role in androgen receptor-mediated transcription.
Title: ZIP kinase plays a crucial role in androgen receptor-mediated transcription.
The specific expression pattern of TCP10L and interaction with DAPK-3 implies that TCP10L might play crucially important roles in spermatogenesis through its interaction with DAPK-3.
Title: TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3.
These results suggest that ZIPK, in collaboration with Daxx and Par-4, mediates a novel nuclear pathway for apoptosis
Title: ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.
data identify hZIPK as the unique SMPP-1-associated kinase expressed in human vesicular smooth muscle and support a role for Rho in promoting the hZIPK-MBS interaction
Title: Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
O43293	Q9NY61	AATF	HPRD	PubMed
O43293	P18848	ATF4	HPRD	PubMed
O43293	P38936	CDKN1A	HPRD	PubMed
O43293	O43293	DAPK3	HPRD	PubMed
O43293	Q9UER7	DAXX	HPRD	PubMed
O43293	P08581	MET	HPRD	PubMed
O43293	Q96IZ0	PAWR	HPRD	PubMed
O43293	Q05513	PRKCZ	HPRD	PubMed
BioGRID:107983	BioGRID:198235	Atf4	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:107983	BioGRID:107985	DAXX	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107983	BioGRID:109145	GRB14	BioGRID	PubMed	Reconstituted Complex
BioGRID:107983	BioGRID:116915	NEDD4L	BioGRID	PubMed	Biochemical Activity
BioGRID:107983	BioGRID:111108	PAWR	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Two-hybrid
BioGRID:107983	BioGRID:111576	PRKCZ	BioGRID	PubMed	Reconstituted Complex
BioGRID:107983	BioGRID:111822	RAD21	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:107983	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:107983	BioGRID:113171	UBE2D3	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
ATP binding	IDA Inferred from Direct Assay more info	PubMed
leucine zipper domain binding	IPI Inferred from Physical Interaction more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
chromatin modification	IEA Inferred from Electronic Annotation more info
cytokinesis	TAS Traceable Author Statement more info
induction of apoptosis	IDA Inferred from Direct Assay more info	PubMed
induction of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
intracellular protein kinase cascade	IDA Inferred from Direct Assay more info	PubMed
neuron differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of canonical Wnt receptor signaling pathway	IMP Inferred from Mutant Phenotype more info
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein autophosphorylation	TAS Traceable Author Statement more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
regulation of actin cytoskeleton reorganization	TAS Traceable Author Statement more info
regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
regulation of autophagy	TAS Traceable Author Statement more info	PubMed
regulation of cell motility	TAS Traceable Author Statement more info
regulation of mitosis	TAS Traceable Author Statement more info
regulation of smooth muscle contraction	TAS Traceable Author Statement more info
regulation of transcription, DNA-dependent	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
PML body	IEA Inferred from Electronic Annotation more info
chromosome	IEA Inferred from Electronic Annotation more info
chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
microtubule organizing center	IEA Inferred from Electronic Annotation more info
nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Preferred Names: death-associated protein kinase 3

Names: death-associated protein kinase 3; dlk; ZIP-kinase; DAP kinase 3; MYPT1 kinase; DAP-like kinase; ZIP kinase isoform; zipper-interacting protein kinase

NP_001339.1

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001348.1 → NP_001339.1 death-associated protein kinase 3

Status: REVIEWED

Source sequence(s)

AB007144

Consensus CDS

CCDS12116.1

UniProtKB/Swiss-Prot

O43293

Related

ENSP00000301264, ENST00000301264

Conserved Domains (2) summary

smart00220
Location:13 – 275
Blast Score: 735

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl09925
Location:11 – 271
Blast Score: 511

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p5 Primary Assembly

Range

3958452..3969826, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

3721681..3733014, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC011488.7 (108023..119397)	None
genomic	CH471139.2	EAW69276.1
genomic	CQ782734.1	CAF85967.1
mRNA	AB007144.1	BAA24955.1
mRNA	AB022341.1	BAA81746.1
mRNA	AB265224.1	BAF34614.1
mRNA	AK027590.1	BAG51355.1
mRNA	AK074799.1	BAG52004.1
mRNA	AK093792.1	BAG52765.1
mRNA	AK097643.1	None
mRNA	BC126430.1	AAI26431.1
mRNA	BC126432.1	AAI26433.1
other-genetic	HQ258253.1	ADR83007.1