DGKQ diacylglycerol kinase, theta 110kDa [Homo sapiens] - Gene

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Summary

Official Symbol: DGKQprovided by HGNC
Official Full Name: diacylglycerol kinase, theta 110kDaprovided by HGNC
Primary source: HGNC:2856
See related: Ensembl:ENSG00000145214; HPRD:03127; MIM:601207; Vega:OTTHUMG00000088629
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DAGK; DAGK4; DAGK7
Summary: The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 4p16.3

Sequence :: Chromosome: 4; NC_000004.11 (952675..967344, complement)

See DGKQ in Epigenomics, MapViewer

Chromosome 4 - NC_000004.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17.
Title: Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17.
Nuclear DGK-theta co-localizes with phosphatidylinositol 4,5-bisphosphate (PIP(2)) in domains that correspond to nuclear speckles.
Title: Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus.
DGK interacts selectively with and is phosphorylated by PKCepsilon and -eta and peptide agonist-induced selective activation of PKCepsilon directly leads to DGK translocation
Title: Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.

Genomewide association study for susceptibility genes contributing to familial Parkinson disease.

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Products	Interactant	Other Gene	Source	Pubs	Description
P52824	P61586	RHOA	HPRD	PubMed
BioGRID:107979	BioGRID:115984	KDM5B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107979	BioGRID:106880	RHOA	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
activating transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
diacylglycerol kinase activity	IDA Inferred from Direct Assay more info	PubMed
kinase binding	IPI Inferred from Physical Interaction more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
phospholipase binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G-protein coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	IEA Inferred from Electronic Annotation more info
blood coagulation	TAS Traceable Author Statement more info
cAMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
intracellular signal transduction	IEA Inferred from Electronic Annotation more info
platelet activation	TAS Traceable Author Statement more info
protein kinase C signaling cascade	IDA Inferred from Direct Assay more info	PubMed
response to ATP	IDA Inferred from Direct Assay more info	PubMed
thrombin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
cytosol	IDA Inferred from Direct Assay more info	PubMed
nuclear speck	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: diacylglycerol kinase theta

Names: diacylglycerol kinase theta; DGK-theta; DAG kinase theta; diglyceride kinase theta

NP_001338.2

EC 2.7.1.107

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347.3 → NP_001338.2 diacylglycerol kinase theta

Status: REVIEWED

Source sequence(s)

AB209503, AC019103, AW139889, BC063801, DN990411

Consensus CDS

CCDS3342.1

UniProtKB/Swiss-Prot

P52824

UniProtKB/TrEMBL

Q59FF7

Related

ENSP00000273814, OTTHUMP00000112179, ENST00000273814, OTTHUMT00000200888

Conserved Domains (6) summary

cd00029
Location:61 – 108
Blast Score: 135

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

COG1597
Location:590 – 900
Blast Score: 170

LCB5; Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]

cd01783
Location:395 – 492
Blast Score: 410

DAGK_delta_RA; Ubiquitin-like domain of Diacylgylcerol kinase (DAGK)

cl00040
Location:122 – 169
Blast Score: 89

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cl01255
Location:590 – 714
Blast Score: 426

DAGK_cat; Diacylglycerol kinase catalytic domain

cl02440
Location:741 – 893
Blast Score: 491

DAGK_acc; Diacylglycerol kinase accessory domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000004.11 Reference GRCh37.p5 Primary Assembly

Range

952675..967344, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000136.1 Alternate HuRef

Range

924043..936230, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC019103.8 (35888..50562)	None
genomic	CH471131.2	EAW82630.1
		EAW82631.1
		EAW82632.1
mRNA	AB209503.1	BAD92740.1
mRNA	AW139889.1	None
mRNA	BC063801.1	AAH63801.1
mRNA	DN990411.1	None
mRNA	GU727647.1	ADU87648.1
mRNA	L38707.1	AAA98749.1