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    Ighg1 immunoglobulin heavy constant gamma 1 (G1m marker) [ Mus musculus (house mouse) ]

    Gene ID: 16017, updated on 26-Feb-2013
    Official Symbol
    Ighg1provided by MGI
    Official Full Name
    immunoglobulin heavy constant gamma 1 (G1m marker)provided by MGI
    Primary source
    MGI:96446
    See related
    IMGT/GENE-DB:IGHG1
    Gene type
    other
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IgG1; Igh-4; VH7183
    Location :
    12 F1; 12 62.1 cM
    Sequence :
    Chromosome: 12; NC_000078.6 (113326544..113330523, complement)
    See Ighg1 in Epigenomics, MapViewer

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene immunoglobulin heavy constant gamma 2C Neighboring gene immunoglobulin heavy constant gamma 2B Neighboring gene immunoglobulin heavy chain complex Neighboring gene FUS interacting protein (serine-arginine rich) 1 pseudogene Neighboring gene Immunoglobulin heavy constant gamma 3

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory. Kaji T, et al. J Exp Med, 2012 Oct 22. PMID 23027924.
    2. The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers. Calado DP, et al. Nat Immunol, 2012 Nov. PMID 23001146.
    3. Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1. Karsten CM, et al. Nat Med, 2012 Sep. PMID 22922409.
    4. Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis. Sander S, et al. Cancer Cell, 2012 Aug 14. PMID 22897848.
    5. ADAM10 regulates transcription factor expression required for plasma cell function. Chaimowitz NS, et al. PLoS One, 2012. PMID 22880085.

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The anti-inflammatory activity of IgG1 is mediated by Fc galactosylation and association with FcgammaRIIB and dectin-1.
      Title: Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1.
    2. Bindings of albumin and IgG to neonatal Fc receptor were additive.
      Title: Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding.
    3. Results describe the domain structure of complement receptor 2 engineered with the Fc fragment of a mouse IgG1 in solution.
      Title: Extended flexible linker structures in the complement chimaeric conjugate CR2-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy.
    4. Determined the contact residues of the complex of the B domain of protein A and intact IgG, which has a molecular mass of 164 kDa and shows weak binding.
      Title: Determination of the interface of a large protein complex by transferred cross-saturation measurements.
    5. The expressed sTNFR:Fc could modulate the inflammatory process during the post-viremic phase of viral myocarditis.
      Title: TNFR-Fc fusion protein expressed by in vivo electroporation improves survival rates and myocardial injury in coxsackievirus induced murine myocarditis.
    Submit: New GeneRIF Correction
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    antigen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    antibacterial humoral response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    antibody-dependent cellular cytotoxicity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    complement activation, classical pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    defense response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    humoral immune response mediated by circulating immunoglobulin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    immunoglobulin mediated immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    phagocytosis, engulfment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    phagocytosis, recognition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of phagocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of type I hypersensitivity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of type IIa hypersensitivity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    immunoglobulin complex, circulating IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_005838.1 Reference

      Range
      78948..82927, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 129S1/SvImJ

    Genomic

    1. NT_114985.3 Reference GRCm38.p1 129S1/SvImJ

      Range
      190446..210017, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p1 BALB/c

    Genomic

    1. NT_096355.1 Reference GRCm38.p1 BALB/c

      Range
      12057..16637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p1 C57BL/6J

      Range
      113326544..113330523, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000034.1 Alternate Mm_Celera

      Range
      114512547..114528723, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01103731.1 None
    genomic AAHY01103732.1 (6744..9856) None
    genomic AC160982.5 (190421..191966) None
    genomic AJ851868.3 (1507513..1527084) None 129/Sv
    genomic D78344.1 BAA11357.1 BALB/c
      BAA11358.1 BALB/c
    genomic J00453.1 AAB59657.1 BALB/c
    genomic J00454.1 AAB59657.1 BALB/c
    mRNA V00775.1 CAA24153.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01868.1 GenPept UniProtKB/Swiss-Prot:P01868
    P01869.2 GenPept UniProtKB/Swiss-Prot:P01869

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • 3D structures
        3D structure of a gene
      • BioProjects
        BioProjects related to a gene
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • GEO Profiles
        Related GEO
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).

      Links to other resources

      General information

      Related sites

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