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Igf2 insulin-like growth factor 2 [ Mus musculus (house mouse) ]

Gene ID: 16002, updated on 8-May-2016
Official Symbol
Igf2provided by MGI
Official Full Name
insulin-like growth factor 2provided by MGI
Primary source
MGI:MGI:96434
See related
Ensembl:ENSMUSG00000048583 Vega:OTTMUSG00000035324
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mpr; M6pr; Peg2; Igf-2; Igf-II; AL033362
Summary
This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. It is an imprinted gene that is expressed only from the paternal allele. The encoded protein undergoes proteolytic processing to generate a mature peptide. The transgenic overexpression of this gene in mice results in prenatal overgrowth, polyhydramnios, fetal and neonatal lethality, disproportionate organ overgrowth including tongue enlargement, and skeletal abnormalities. Mice lacking the encoded protein exhibit growth deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]
Orthologs
Location:
7 F5; 7 87.99 cM
Exon count:
7
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (142650768..142662270, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (149836673..149846940, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene microRNA 675 Neighboring gene H19, imprinted maternally expressed transcript Neighboring gene predicted gene, 33148 Neighboring gene microRNA 483 Neighboring gene insulin-like growth factor 2, opposite strand Neighboring gene insulin II Neighboring gene predicted gene, 39116

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
hormone activity IEA
Inferred from Electronic Annotation
more info
 
insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
exocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
insulin receptor signaling pathway via phosphatidylinositol 3-kinase IMP
Inferred from Mutant Phenotype
more info
PubMed 
memory ISO
Inferred from Sequence Orthology
more info
 
negative regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
ossification IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of catalytic activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glycogen (starch) synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glycogen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of steroid hormone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
response to drug ISO
Inferred from Sequence Orthology
more info
 
response to nicotine ISO
Inferred from Sequence Orthology
more info
 
response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
striated muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
insulin-like growth factor II
Names
multiplication-stimulating polypeptide

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122736.2NP_001116208.1  insulin-like growth factor II isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001116208.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC013548, BC058615, CN527329
    Consensus CDS
    CCDS52458.1
    UniProtKB/Swiss-Prot
    P09535
    Related
    ENSMUSP00000101556, OTTMUSP00000015967, ENSMUST00000105936, OTTMUST00000035619
    Conserved Domains (2) summary
    pfam08365
    Location:112166
    IGF2_C; Insulin-like growth factor II E-peptide
    cd04368
    Location:2891
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
  2. NM_001122737.2NP_001116209.1  insulin-like growth factor II isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001116209.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AC013548, BC058615
    Consensus CDS
    CCDS52458.1
    UniProtKB/Swiss-Prot
    P09535
    Related
    ENSMUSP00000000033, OTTMUSP00000015965, ENSMUST00000000033, OTTMUST00000035617
    Conserved Domains (2) summary
    pfam08365
    Location:112166
    IGF2_C; Insulin-like growth factor II E-peptide
    cd04368
    Location:2891
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
  3. NM_001315488.1NP_001302417.1  insulin-like growth factor II isoform 2 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate exon at its 5' terminus and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AC013548, CN666734
    UniProtKB/Swiss-Prot
    P09535
    Conserved Domains (2) summary
    pfam08365
    Location:112166
    IGF2_C; Insulin-like growth factor II E-peptide
    cd04368
    Location:2891
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
  4. NM_001315489.1NP_001302418.1  insulin-like growth factor II isoform 2 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate exon at its 5' terminus, lacks a portion of the 3' UTR and uses a downstream in-frame start codon, compared to variant 1. This results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1. Variants 2, 3, 4 and 5 encode the same protein.
    Source sequence(s)
    AC013548, BC053489
    UniProtKB/Swiss-Prot
    P09535
    Conserved Domains (2) summary
    pfam08365
    Location:112166
    IGF2_C; Insulin-like growth factor II E-peptide
    cd04368
    Location:2891
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...
  5. NM_010514.3NP_034644.2  insulin-like growth factor II isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). This isoform (1) may undergo proteolytic processing similar to isoform 2.
    Source sequence(s)
    AC013548, CF742200
    Consensus CDS
    CCDS22033.2
    UniProtKB/TrEMBL
    E9QLW5
    Related
    ENSMUSP00000114076, OTTMUSP00000015966, ENSMUST00000121128, OTTMUST00000035618
    Conserved Domains (2) summary
    pfam08365
    Location:123177
    IGF2_C; Insulin-like growth factor II E-peptide
    cd04368
    Location:39102
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    142650768..142662270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508487.1XP_006508550.1  

    See identical proteins and their annotated locations for XP_006508550.1

    UniProtKB/Swiss-Prot
    P09535
    Conserved Domains (2) summary
    pfam08365
    Location:112166
    IGF2_C; Insulin-like growth factor II E-peptide
    cd04368
    Location:2891
    IlGF; IlGF, insulin_like growth factors; specific to vertebrates. Members include a number of peptides including insulin-like growth factors I and II, which play a variety of roles in controlling processes such as growth, differentiation, and reproduction. On ...

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    142407105..142417364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)