Cxcl10 chemokine (C-X-C motif) ligand 10 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Cxcl10provided by MGI
Official Full Name: chemokine (C-X-C motif) ligand 10provided by MGI
Primary source: MGI:1352450
See related: Ensembl:ENSMUSG00000034855; Vega:OTTMUSG00000028740
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C7; IP10; CRG-2; INP10; IP-10; Ifi10; mob-1; Scyb10; gIP-10

Genomic context

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Location :: 5 E2; 5 46.57 cM

Sequence :: Chromosome: 5; NC_000071.6 (92346638..92348889, complement)

See Cxcl10 in Epigenomics, MapViewer

Chromosome 5 - NC_000071.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

CXCL10 is directly involved in the generation of a parasite specific CD8+ T cell-mediated immune response.
Title: CXCL10 is critical for the generation of protective CD8 T cell response induced by antigen pulsed CpG-ODN activated dendritic cells.
This study demonstrates that central nervous system-expressed CXCR3 ligand CXCL10 is the critical chemokine regulating antibody-secreting cell accumulation during coronavirus-induced encephalomyelitis.
Title: Astrocyte-derived CXCL10 drives accumulation of antibody-secreting cells in the central nervous system during viral encephalomyelitis.
we provide in vitro and in vivo evidence that CXCL10 exerts proapoptotic effects in hepatocytes through its noncognate receptor (TLR4).
Title: Proapoptotic effects of the chemokine, CXCL 10 are mediated by the noncognate receptor TLR4 in hepatocytes.
CXCL9/10 have antifibrotic roles on liver non-parenchymal cells
Title: Gene profile of chemokines on hepatic stellate cells of schistosome-infected mice and antifibrotic roles of CXCL9/10 on liver non-parenchymal cells.
Data indicate that upregulation of CXCR3 by germinal center (GC) B cells and antibody-forming cells (AFCs) and their migration toward its ligand CXCL10 are shown to depend on B cells' intrinsic T-bet.
Title: CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines.
findings show that effector T cells cannot accumulate within the decidua, the specialized stromal tissue encapsulating the fetus and placenta; impaired accumulation was in part attributable to the epigenetic silencing of key T cell-attracting inflammatory chemokine genes in decidual stromal cells
Title: Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface.
Heme/HO-1, CXCL10/CXCR3 and STAT3 molecules as well as related signaling pathways play very important roles in the pathogenesis of severe malaria
Title: Heme mediated STAT3 activation in severe malaria.
results suggest that excretory/secretory products suppress the IP-10 gene expression by inhibiting the IFN-stimulated response element- and RelA-dependent transcriptional activities in mouse macrophages
Title: Suppression of IP-10/CXCL10 gene expression in LPS- and/or IFN-γ-stimulated macrophages by parasite-secreted products.
Lactocepin secreted by Lactobacillus exerts anti-inflammatory effects by selectively degrading proinflammatory IP-10.
Title: Lactocepin secreted by Lactobacillus exerts anti-inflammatory effects by selectively degrading proinflammatory chemokines.
CXCL10 facilitates trafficking of CXCR3-expressing cancer cells to bone, which augments its own production and promotes osteoclastic differentiation
Title: CXCL10 promotes osteolytic bone metastasis by enhancing cancer outgrowth and osteoclastogenesis.

Submit: New GeneRIF Correction See all (106)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NC_000071.1	NP_067506.2	Carm1	BIND	PubMed	CARM1 interacts with the IP-10 gene.
NC_000071.1	NP_062342.1	Hist2h3c1	BIND	PubMed	H3 interacts with the IP-10 gene.
NC_000071.1	NP_033071.1	Rela	BIND	PubMed	p65 interacts with the IP-10 gene.

Pathways from BioSystems

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Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
Chemokine receptors bind chemokines, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Chemokine signaling pathway, organism-specific biosystem (from KEGG)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, organism-specific biosystem (from WikiPathways)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, conserved biosystem (from KEGG)
Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
Cytosolic DNA-sensing pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
Cytosolic DNA-sensing pathway, conserved biosystem (from KEGG)
Cytosolic DNA-sensing pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
G alpha (i) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Influenza A, organism-specific biosystem (from KEGG)
Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
Influenza A, conserved biosystem (from KEGG)
Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
Peptide ligand-binding receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

General gene information

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Markers

M86829 (e-PCR)
- UniSTS:124995

Cxcl10 (e-PCR), detects polymorphism
- UniSTS:506828

AI661308 (e-PCR)
- UniSTS:207821

Homology

Homologs of the Cxcl10 gene: The Cxcl10 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
chemokine activity	ISO Inferred from Sequence Orthology more info
cytokine activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
chemotaxis	IEA Inferred from Electronic Annotation more info
defense response to virus	IDA Inferred from Direct Assay more info	PubMed
immune response	ISO Inferred from Sequence Orthology more info
inflammatory response	IEA Inferred from Electronic Annotation more info
negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of leukocyte chemotaxis	ISO Inferred from Sequence Orthology more info
protein secretion	ISO Inferred from Sequence Orthology more info
signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
extracellular region	ISO Inferred from Sequence Orthology more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-X-C motif chemokine 10

Names: C-X-C motif chemokine 10; gamma-IP10; interferon activated gene 10; small-inducible cytokine B10; interferon-gamma induced protein CRG-2; interferon-gamma-induced protein CRG-2; 10 kDa interferon gamma-induced protein; small inducible cytokine B subfamily (Cys-X-Cys), member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021274.2 → NP_067249.1 C-X-C motif chemokine 10 precursor

Status: VALIDATED

Source sequence(s)

BC030067, BY165450

Consensus CDS

CCDS39153.1

UniProtKB/Swiss-Prot

P17515

UniProtKB/TrEMBL

Q548V9

Related

ENSMUSP00000047646, OTTMUSP00000036424, ENSMUST00000038816, OTTMUST00000071189

Conserved Domains (1) summary

cd00273
Location:27 – 89
Blast Score: 154

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000071.6 Reference GRCm38.p1 C57BL/6J

Range

92346638..92348889, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000027.1 Alternate Mm_Celera

Range

90490433..90492679, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01046867.1 (1961..4207)	None
genomic	AC109603.8 (29220..31433)	None	129/Sv
genomic	AC122365.4 (94711..96924)	None
genomic	CH466617.2	EDL05256.1	mixed
genomic	L07417.1	AAA75249.1	DBA/2J
genomic	M86830.1	None
mRNA	AF227743.1	AAG10400.1	SJL/J
mRNA	AJ243095.1	None	MRL
mRNA	AK144279.1	BAE25810.1	C57BL/6J
mRNA	AK146144.1	BAE26931.1	DBA/2
mRNA	AK150380.1	BAE29511.1	C57BL/6J
mRNA	AK150765.1	BAE29832.1	C57BL/6J
mRNA	AK150987.1	None	C57BL/6J
mRNA	AK151210.1	BAE30205.1	C57BL/6J
mRNA	AK151248.1	BAE30238.1	C57BL/6J
mRNA	AK151415.1	BAE30380.1	C57BL/6J
mRNA	AK151534.1	BAE30481.1	C57BL/6J
mRNA	AK152568.1	BAE31320.1	C57BL/6J
mRNA	AK152814.1	BAE31517.1	C57BL/6J
mRNA	AK152838.1	None	C57BL/6J
mRNA	AK152924.1	BAE31599.1	C57BL/6J
mRNA	AK153181.1	BAE31783.1	C57BL/6J
mRNA	AK156907.1	None	NOD
mRNA	AK157130.1	BAE33973.1	NOD
mRNA	AK157139.1	BAE33975.1	NOD
mRNA	AK157589.1	BAE34130.1	NOD
mRNA	AK157678.1	BAE34149.1	NOD
mRNA	AK172540.1	BAE43058.1	NOD
mRNA	BC030067.1	AAH30067.1	C57BL/6J
mRNA	BC057150.1	None	NMRI
mRNA	BY165450.1	None	C57BL/6J
mRNA	M33266.1	AAA02968.1	C57BL/6
mRNA	M86829.1	AAA21489.1