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AK8 adenylate kinase 8 [ Homo sapiens (human) ]

Gene ID: 158067, updated on 26-May-2016
Official Symbol
AK8provided by HGNC
Official Full Name
adenylate kinase 8provided by HGNC
Primary source
HGNC:HGNC:26526
See related
Ensembl:ENSG00000165695 HPRD:12991; MIM:615365; Vega:OTTHUMG00000021009
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AK 8; DDX31; C9orf98
Orthologs
Location:
9q34.13
Exon count:
16
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (132725574..132878811, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (135600958..135754198, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene BarH like homeobox 1 Neighboring gene DEAD-box helicase 31 Neighboring gene general transcription factor IIIC subunit 4 Neighboring gene sperm acrosome associated 9 Neighboring gene tuberous sclerosis 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
NHGRI GWA Catalog
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ32704, FLJ36014

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
adenylate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
cytidylate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
nucleoside diphosphate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
nucleoside kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
nucleobase-containing small molecule interconversion TAS
Traceable Author Statement
more info
 
nucleoside diphosphate phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
nucleoside triphosphate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
ventricular system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axoneme IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
sperm flagellum IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
adenylate kinase 8
Names
ATP-AMP transphosphorylase 8
putative adenylate kinase-like protein C9orf98
NP_689785.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317958.1NP_001304887.1  adenylate kinase 8 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream start site and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK093446, BC037402, BC050576
    UniProtKB/Swiss-Prot
    Q96MA6
    Conserved Domains (2) summary
    cd01428
    Location:66258
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:66264
    adk; adenylate kinase
  2. NM_001317959.1NP_001304888.1  adenylate kinase 8 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple coding region differences, compared to variant 1. These differences cause translation initiation at an alternate start site and result in a shorter isoform (3) with a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL445645, BC037402, BC050576
    UniProtKB/Swiss-Prot
    Q96MA6
    Conserved Domains (2) summary
    cd01428
    Location:98290
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:98296
    adk; adenylate kinase
  3. NM_152572.2NP_689785.1  adenylate kinase 8 isoform 1

    See identical proteins and their annotated locations for NP_689785.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC050576
    Consensus CDS
    CCDS6954.1
    UniProtKB/Swiss-Prot
    Q96MA6
    Related
    ENSP00000298545, OTTHUMP00000022737, ENST00000298545, OTTHUMT00000055413
    Conserved Domains (2) summary
    cd01428
    Location:270462
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:270468
    adk; adenylate kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    132725574..132878811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716964.2XP_006717027.1  

    Conserved Domains (2) summary
    cd01428
    Location:225417
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:225423
    adk; adenylate kinase
  2. XM_011518280.1XP_011516582.1  

    Conserved Domains (2) summary
    cd01428
    Location:66258
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:66264
    adk; adenylate kinase
  3. XM_005272169.2XP_005272226.1  

    Conserved Domains (2) summary
    cd01428
    Location:282474
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:282480
    adk; adenylate kinase
  4. XM_011518278.1XP_011516580.1  

    Conserved Domains (2) summary
    cd01428
    Location:196388
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:196394
    adk; adenylate kinase
  5. XM_006716965.2XP_006717028.1  

    Conserved Domains (2) summary
    cd01428
    Location:198390
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:198396
    adk; adenylate kinase
  6. XM_011518279.1XP_011516581.1  

    Conserved Domains (2) summary
    cd01428
    Location:98290
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:98296
    adk; adenylate kinase
  7. XM_011518277.1XP_011516579.1  

    Conserved Domains (3) summary
    cd01428
    Location:71261
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    TIGR01351
    Location:71270
    adk; adenylate kinase
    cl17190
    Location:282335
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RNA

  1. XR_929719.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    135751293..135904675 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)