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CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 [ Homo sapiens (human) ]

Gene ID: 1577, updated on 24-Jan-2015
Official Symbol
CYP3A5provided by HGNC
Official Full Name
cytochrome P450, family 3, subfamily A, polypeptide 5provided by HGNC
Primary source
HGNC:HGNC:2638
See related
Ensembl:ENSG00000106258; HPRD:05617; MIM:605325; Vega:OTTHUMG00000156724
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CP35; PCN3; CYPIIIA5; P450PCN3
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein metabolizes drugs as well as the steroid hormones testosterone and progesterone. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Two pseudogenes of this gene have been identified within this cluster on chromosome 7. Expression of this gene is widely variable among populations, and a single nucleotide polymorphism that affects transcript splicing has been associated with susceptibility to hypertensions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Orthologs
See CYP3A5 in MapViewer
Location:
7q21.1
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 7 NC_000007.14 (99648190..99679998, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99245813..99277636, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene transmembrane protein 225-like Neighboring gene zinc finger and SCAN domain containing 25 Neighboring gene ADP-ribosylation factor 6 pseudogene Neighboring gene CYP3A7-CYP3A51P readthrough Neighboring gene cytochrome P450, family 3, subfamily A, polypeptide 51, pseudogene Neighboring gene cytochrome P450, family 3, subfamily A, polypeptide 7

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Essential hypertension
MedGen: C0085580 OMIM: 145500 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ31317, DKFZp686L16231

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aromatase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxygen binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
alkaloid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
drug catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidative demethylation IDA
Inferred from Direct Assay
more info
PubMed 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
steroid metabolic process TAS
Traceable Author Statement
more info
PubMed 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
cytochrome P450 3A5
Names
cytochrome P450 3A5
cytochrome P450 HLp2
cytochrome P450-PCN3
microsomal monooxygenase
xenobiotic monooxygenase
aryl hydrocarbon hydroxylase
flavoprotein-linked monooxygenase
cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5
NP_000768.1
NP_001177413.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007938.1 

    Range
    4973..36810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000777.4NP_000768.1  cytochrome P450 3A5 isoform 1

    See proteins identical to NP_000768.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA076026, BC033862, DC383127
    Consensus CDS
    CCDS5672.1
    UniProtKB/Swiss-Prot
    P20815
    Related
    ENSP00000222982, OTTHUMP00000210469, ENST00000222982, OTTHUMT00000345469
    Conserved Domains (1) summary
    pfam00067
    Location:39492
    p450; Cytochrome P450
  2. NM_001190484.2NP_001177413.1  cytochrome P450 3A5 isoform 2

    See proteins identical to NP_001177413.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several exons and uses an alternate 3' exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK299002, BC022298, DC383127
    Consensus CDS
    CCDS55134.1
    UniProtKB/Swiss-Prot
    P20815
    Related
    ENSP00000401269, OTTHUMP00000210470, ENST00000439761, OTTHUMT00000345471
    Conserved Domains (1) summary
    cl12078
    Location:39113
    p450; Cytochrome P450
  3. NM_001291829.1NP_001278758.1  cytochrome P450 3A5 isoform 3

    See proteins identical to NP_001278758.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA076026, BC025176, DC383127
    Conserved Domains (1) summary
    pfam00067
    Location:5379
    p450; Cytochrome P450
  4. NM_001291830.1NP_001278759.1  cytochrome P450 3A5 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AA076026, AK296205, DC383127
    UniProtKB/TrEMBL
    B7Z3P6
    Conserved Domains (1) summary
    pfam00067
    Location:29482
    p450; Cytochrome P450

RNA

  1. NR_033807.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes 3 alternate internal segments, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AA076026, BC025176, BX537676, BX648856, DC383127

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000007.14 

    Range
    99648190..99679998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715860.1XP_006715923.1  

    Conserved Domains (1) summary
    pfam00067
    Location:1312
    p450; Cytochrome P450
  2. XM_006715859.1XP_006715922.1  

    See proteins identical to XP_006715922.1

    Conserved Domains (1) summary
    cl12078
    Location:39343
    p450; Cytochrome P450

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 

    Range
    99175907..99207720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000139.1 

    Range
    93882179..93914147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_033810.1: Suppressed sequence

    Description
    NR_033810.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
  2. NR_033811.1: Suppressed sequence

    Description
    NR_033811.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
  3. NR_033812.1: Suppressed sequence

    Description
    NR_033812.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.