CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 [Homo sapiens] - Gene

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Summary

Official Symbol: CYP3A5provided by HGNC
Official Full Name: cytochrome P450, family 3, subfamily A, polypeptide 5provided by HGNC
Primary source: HGNC:2638
See related: Ensembl:ENSG00000106258; HPRD:05617; MIM:605325; Vega:OTTHUMG00000156724
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CP35; PCN3; CYPIIIA5; P450PCN3; FLJ31317; DKFZp686L16231
Summary: This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2010]

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Genomic context

Location :: 7q21.1

Sequence :: Chromosome: 7; NC_000007.13 (99245813..99277621, complement)

See CYP3A5 in Epigenomics, MapViewer

Chromosome 7 - NC_000007.13 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that in liver microsomes tamoxifen N-demethylation is mediated by both CYP3A5 and CYP3A4. Polymorphisms in CYP3A5 appear to affect formation of N-desmethyltamoxifen in liver microsomes and recombinant proteins.
Title: Assessment of the impact of CYP3A polymorphisms on the formation of α-hydroxytamoxifen and N-desmethyltamoxifen in human liver microsomes.
The impact of CYP3A5 genotype of recipients (intestine) as well as donors (graft liver) on tacrolimus pharmacokinetics and the incidence of infectious complications was assessed in Japanese living-donor liver transplant recipients.
Title: Impact of CYP3A5 genotype of recipients as well as donors on the tacrolimus pharmacokinetics and infectious complications after living-donor liver transplantation for Japanese adult recipients.
Noroxycodone C(12) and its ratio to oxycodone C(12) were significantly higher in the CYP3A5*1 carrier group than in the *3/*3 group.
Title: CYP3A5*3 affects plasma disposition of noroxycodone and dose escalation in cancer patients receiving oxycodone.
This meta-analysis suggested a modestly significant association between the CYP3A5 rs776746 polymorphism and systolic BP in white populations.
Title: Association of the CYP3A5 polymorphism (6986G>A) with blood pressure and hypertension.
cyp3a5 polymorphisms affected the tacrolimus PharmakoKinetics
Title: Association of ABCB1, CYP3A4*18B and CYP3A5*3 genotypes with the pharmacokinetics of tacrolimus in healthy Chinese subjects: a population pharmacokinetic analysis.
CYP3A5 polymorphisms are associated with the severity and degree of hypertension in kidney transplant recipients receiving calcineurin inhibitors.
Title: Association between CYP3A5 polymorphisms and blood pressure in kidney transplant recipients receiving calcineurin inhibitors.
This study confirmed significant inter-ethnic differences in CYP3A5 and P2Y12 frequencies between Iranians and other ethnic groups.
Title: The investigation of allele and genotype frequencies of CYP3A5 (1/3) and P2Y12 (T744C) in Iran.
Polymorphism of CYP3A5 and CYP3A4 genes were investigated in 50 patients with laryngeal squamous cell carcinoma.
Title: Study the polymorphism of CYP3A5 and CYP3A4 loci in Iranian population with laryngeal squamous cell carcinoma.
The CYP3A5 genotype has minimal effects on the pharmacokinetic parameters of atorvastatin and its interaction with clarithromycin; these effects are unlikely to be clinically significant.
Title: Effect of cytochrome P450 3A5 genotype on atorvastatin pharmacokinetics and its interaction with clarithromycin.
CYP3A5 polymorphism has an effect on tacrolimus maintenance doses and serum levels after renal transplantation
Title: Influence of CYP3A5 polymorphism on tacrolimus maintenance doses and serum levels after renal transplantation: age dependency and pharmacological interaction with steroids.

Submit: New GeneRIF Correction See all (163)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Hypertension, salt-sensitive essential, susceptibility to

MIM: 145500

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
NP_000768.1				BIND	PubMed	CYP3A5 interacts with Meperidine.

Function	Evidence Code	Pubs
aromatase activity	IEA Inferred from Electronic Annotation more info
electron carrier activity	IEA Inferred from Electronic Annotation more info
heme binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
monooxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
oxidoreductase activity	IDA Inferred from Direct Assay more info	PubMed
oxygen binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
alkaloid catabolic process	IDA Inferred from Direct Assay more info	PubMed
drug catabolic process	IDA Inferred from Direct Assay more info	PubMed
oxidative demethylation	IDA Inferred from Direct Assay more info	PubMed
small molecule metabolic process	TAS Traceable Author Statement more info
steroid metabolic process	TAS Traceable Author Statement more info	PubMed
xenobiotic metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum membrane	TAS Traceable Author Statement more info
membrane	IEA Inferred from Electronic Annotation more info
microsome	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: cytochrome P450 3A5

Names: cytochrome P450 3A5; cytochrome P-450; niphedipine oxidase; cytochrome P450 HLp2; cytochrome P450-PCN3; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5

NP_000768.1

EC 1.14.14.1

NP_001177413.1

EC 1.14.14.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007938.1 RefSeqGene

Range

5001..36809

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000777.3 → NP_000768.1 cytochrome P450 3A5 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AA076026, BC025176, BC033862, BX537676

Consensus CDS

CCDS5672.1

UniProtKB/Swiss-Prot

P20815

UniProtKB/TrEMBL

Q7Z3N0

Related

ENSP00000222982, OTTHUMP00000210469, ENST00000222982, OTTHUMT00000345469

Conserved Domains (2) summary

pfam00067
Location:51 – 492
Blast Score: 1050

p450; Cytochrome P450

cl12078
Location:60 – 489
Blast Score: 492

CypX; Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]
NM_001190484.1 → NP_001177413.1 cytochrome P450 3A5 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks multiple 3' exons, and has an alternate 3' exon, as compared to variant 1. The resulting isoform (2) is much shorter and has an alternate C-terminus, as compared to isoform 1.

Source sequence(s)

AK299002, BC022298, BX537676

Consensus CDS

CCDS55134.1

UniProtKB/Swiss-Prot

P20815

UniProtKB/TrEMBL

Q7Z3N0

Related

ENSP00000401269, OTTHUMP00000210470, ENST00000439761, OTTHUMT00000345471

Conserved Domains (1) summary

pfam00067
Location:51 – 100
Blast Score: 105

p450; Cytochrome P450

RNA

NR_033807.1 RNA Sequence

Description

Transcript Variant: This variant (3) has two additional segments in the 5' and middle regions respectively, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate, and most likely does not make a functional protein.

Source sequence(s)

AA076026, BX537676, BX648856
NR_033808.1 RNA Sequence

Description

Transcript Variant: This variant (4) has an additional segment in the 5' region, as compared to variant (1), which includes a translation stop codon. The transcript is a nonsense-mediated mRNA decay candidate, and most likely does not make a functional protein.

Source sequence(s)

AA076026, BC025176, BX537676
NR_033809.1 RNA Sequence

Description

Transcript Variant: This variant (5) has an additional exon in the 5' region, as compared to variant (1), which includes a translation stop codon. The transcript is a nonsense-mediated mRNA decay candidate, and most likely does not make a functional protein.

Source sequence(s)

AA076026, AK296205, BC025176, BX537676
NR_033810.1 RNA Sequence

Description

Transcript Variant: This variant (6) has two additional segments in the 5' and middle regions respectively, and lacks several 3' exons, but has an alternate 3' exon, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate, and most likely does not make a functional protein.

Source sequence(s)

BX537676, BX648856
NR_033811.1 RNA Sequence

Description

Transcript Variant: This variant (7) differs in several places, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate, and most likely does not make a functional protein.

Source sequence(s)

BC026255, BX537676, L26985, X90579
NR_033812.1 RNA Sequence

Description

Transcript Variant: This variant (8) has an additional exon in the 5' region, and lacks several 3' exons, but has an alternate 3' segment, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate, and most likely does not make a functional protein.

Source sequence(s)

BX537676, X90579

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000007.13 Reference GRCh37.p5 Primary Assembly

Range

99245813..99277621, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000139.1 Alternate HuRef

Range

93882179..93914147, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CRA_TCAGchr7v2

Genomic

AC_000068.1 Alternate CRA_TCAGchr7v2

Range

98605608..98637429, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC005020.5	AAS02016.1
genomic	AF280107.1	AAG32288.1
genomic	AF355803.1	AAK73691.1
genomic	CH236956.1	EAL23868.1
genomic	CH471091.2	EAW76638.1
		EAW76639.1
		EAW76640.1
		EAW76641.1
		EAW76642.1
genomic	DQ680079.1	ABG25922.1
genomic	L35912.1	AAB00083.1
mRNA	AA076026.1	None
mRNA	AF355801.1	AAK73689.1
mRNA	AF355802.1	AAK73690.1
mRNA	AF355804.1	None
mRNA	AJ563378.1	CAD91347.1
		CAD91647.1
mRNA	AJ563378.1	CAD91347.1
		CAD91647.1
mRNA	AJ563379.1	CAD91649.1
mRNA	AK055879.1	None
mRNA	AK223008.1	BAD96728.1
mRNA	AK296205.1	BAH12282.1
mRNA	AK299002.1	BAH12923.1
mRNA	AK309166.1	None
mRNA	AK313813.1	BAG36549.1
mRNA	BC022298.1	None
mRNA	BC025176.1	None
mRNA	BC026255.1	None
mRNA	BC033862.1	AAH33862.1
mRNA	BX537676.1	CAD97807.1
mRNA	BX648856.1	None
mRNA	J04813.1	AAA02993.1
mRNA	L26985.1	None
mRNA	X90579.1	None
other-genetic	DQ890743.2	ABM81669.1
other-genetic	DQ893913.2	ABM84839.1
other-genetic	DQ896802.2	ABM87801.1
other-genetic	EU176488.1	ABW03289.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P20815.1	GenPept	UniProtKB/Swiss-Prot:P20815
Q14V85	GenPept	UniProtKB/TrEMBL:Q14V85
Q53GC3	GenPept	UniProtKB/TrEMBL:Q53GC3
Q7Z3N0	GenPept	UniProtKB/TrEMBL:Q7Z3N0
Q7Z446	GenPept	UniProtKB/TrEMBL:Q7Z446
Q7Z447	GenPept	UniProtKB/TrEMBL:Q7Z447
Q86SK1	GenPept	UniProtKB/TrEMBL:Q86SK1
Q96RK6	GenPept	UniProtKB/TrEMBL:Q96RK6
Q96RK8	GenPept	UniProtKB/TrEMBL:Q96RK8