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CYP3A4 cytochrome P450 family 3 subfamily A member 4 [ Homo sapiens (human) ]

Gene ID: 1576, updated on 15-May-2016
Official Symbol
CYP3A4provided by HGNC
Official Full Name
cytochrome P450 family 3 subfamily A member 4provided by HGNC
Primary source
HGNC:HGNC:2637
See related
Ensembl:ENSG00000160868 HPRD:00484; MIM:124010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]
Orthologs
Location:
7q21.1
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (99756960..99784188, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99354583..99381811, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 25 Neighboring gene CYP3A7-CYP3A51P readthrough Neighboring gene cytochrome P450 family 3 subfamily A member 7 Neighboring gene cytochrome P450, family 3, subfamily A, polypeptide 5 pseudogene 2 Neighboring gene cytochrome P450 family 3 subfamily A member 43 Neighboring gene olfactory receptor family 2 subfamily AE member 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Esomeprazole response
MedGen: CN077982 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Human metabolic individuality in biomedical and pharmaceutical research.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC126680

Gene Ontology Provided by GOA

Function Evidence Code Pubs
albendazole monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
aromatase activity IEA
Inferred from Electronic Annotation
more info
 
caffeine oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IDA
Inferred from Direct Assay
more info
PubMed 
monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
monooxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxygen binding TAS
Traceable Author Statement
more info
 
quinine 3-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
steroid binding IDA
Inferred from Direct Assay
more info
PubMed 
steroid hydroxylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
taurochenodeoxycholate 6alpha-hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
testosterone 6-beta-hydroxylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
vitamin D 24-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
vitamin D3 25-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
alkaloid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
androgen metabolic process TAS
Traceable Author Statement
more info
PubMed 
calcitriol biosynthetic process from calciol IEA
Inferred from Electronic Annotation
more info
 
drug catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
drug catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
drug metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
exogenous drug catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
heterocycle metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
monoterpenoid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
oxidative demethylation IDA
Inferred from Direct Assay
more info
PubMed 
steroid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
steroid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
vitamin D metabolic process IC
Inferred by Curator
more info
PubMed 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
cytochrome P450 3A4
Names
1,8-cineole 2-exo-monooxygenase
P450-III, steroid inducible
albendazole monooxygenase
albendazole sulfoxidase
cholesterol 25-hydroxylase
cytochrome P450 3A3
cytochrome P450 HLp
cytochrome P450 NF-25
cytochrome P450, family 3, subfamily A, polypeptide 4
cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3
cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
cytochrome P450-PCN1
glucocorticoid-inducible P450
nifedipine oxidase
quinine 3-monooxygenase
taurochenodeoxycholate 6-alpha-hydroxylase
NP_001189784.1
NP_059488.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008421.1 RefSeqGene

    Range
    4998..32226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202855.2NP_001189784.1  cytochrome P450 3A4 isoform 2

    See identical proteins and their annotated locations for NP_001189784.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the CDS compared to variant 1. The resulting isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC069294, BC101631, J04449
    UniProtKB/Swiss-Prot
    P08684
    UniProtKB/TrEMBL
    Q6GRK0
    Conserved Domains (1) summary
    pfam00067
    Location:39492
    p450; Cytochrome P450
  2. NM_017460.5NP_059488.2  cytochrome P450 3A4 isoform 1

    See identical proteins and their annotated locations for NP_059488.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC069294, AK312967
    Consensus CDS
    CCDS5674.1
    UniProtKB/Swiss-Prot
    P08684
    UniProtKB/TrEMBL
    Q6GRK0
    Related
    ENSP00000337915, OTTHUMP00000210308, ENST00000336411, OTTHUMT00000345059
    Conserved Domains (1) summary
    pfam00067
    Location:39493
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    99756960..99784188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515842.1XP_011514144.1  

    Conserved Domains (1) summary
    pfam00067
    Location:39523
    p450; Cytochrome P450
  2. XM_011515841.1XP_011514143.1  

    Conserved Domains (1) summary
    pfam00067
    Location:39524
    p450; Cytochrome P450

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    99284687..99311925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001202856.1: Suppressed sequence

    Description
    NM_001202856.1: This RefSeq was permanently suppressed because it represents a product of trans-splicing and is not in scope for the RefSeq collection.
  2. NM_001202857.1: Suppressed sequence

    Description
    NM_001202857.1: This RefSeq was permanently suppressed because it represents a product of trans-splicing and is not in scope for the RefSeq collection.