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    FBXO16 F-box protein 16 [ Homo sapiens ]

    Gene ID: 157574, updated on 11-May-2012
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    Summary

    Official Symbol
    FBXO16provided by HGNC
    Official Full Name
    F-box protein 16provided by HGNC
    Primary source
    HGNC:13618
    See related
    Ensembl:ENSG00000214050; HPRD:16347; MIM:608519; Vega:OTTHUMG00000102147
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBX16; MGC125923; MGC125924; MGC125925
    Summary
    This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
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    Genomic context

    Location :
    8p21.1
    Sequence :
    Chromosome: 8; NC_000008.10 (28285929..28347784, complement)
    See FBXO16 in Epigenomics, MapViewer

    Chromosome 8 - NC_000008.10Genomic Context describing neighboring genes Neighboring gene prepronociceptin Neighboring gene zinc finger protein 395 Neighboring gene microRNA 4288 Neighboring gene frizzled family receptor 3 Neighboring gene exostoses (multiple)-like 3

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. Vanderwerf SM, et al. Blood, 2009 Dec 17. PMID 19850743.
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
    5. cDNA cloning and expression analysis of a novel human F-box only protein. Cheng H, et al. Mol Cells, 2002 Aug 31. PMID 12243353.

    See all (7) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. FBXO16 was localized to the human chromosome 8p12. The FBXO16 gene consisted of 9 exons that spanned 67,816 bp of human genomic DNA
      Title: cDNA cloning and expression analysis of a novel human F-box only protein.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q8IX29 P63208 SKP1    HPRD  PubMed  
    BioGRID:127606 BioGRID:113164 UBC    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Potential readthrough

    Included gene: ZNF395

    Homology

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    General protein information

    Preferred Names
    F-box only protein 16
    Names
    F-box only protein 16
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001258211.1 → NP_001245140.1  F-box only protein 16 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
      Source sequence(s)
      AA765256, AC025871, BC102028
      Conserved Domains (1) summary
      cl02535
      Location:79 – 123
      Blast Score: 148
      F-box; F-box domain

    2. NM_172366.3 → NP_758954.1  F-box only protein 16 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AA765256, AC025871, AF453435, CB134505
      Consensus CDS
      CCDS6068.1
      UniProtKB/Swiss-Prot
      Q8IX29
      Related
      ENSP00000369604, OTTHUMP00000128340, ENST00000380254, OTTHUMT00000219988
      Conserved Domains (1) summary
      cl02535
      Location:91 – 135
      Blast Score: 147
      F-box; F-box domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000008.10 Reference GRCh37.p5 Primary Assembly

      Range
      28285929..28347784, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000140.1 Alternate HuRef

      Range
      26830959..26893031, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC025871.8 (414..62269) None
    genomic CH471080.2 EAW63512.1
      EAW63513.1
      EAW63514.1
      EAW63515.1
      EAW63516.1
      EAW63517.1
      EAW63518.1
    mRNA AF453435.1 AAN76812.1
    mRNA AK098243.1 None
    mRNA AL560247.3 None
    mRNA BC074986.2 AAH74986.1
    mRNA BC102026.1 AAI02027.1
    mRNA BC102027.1 AAI02028.1
    mRNA BC102028.1 AAI02029.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3T1B2 GenPept UniProtKB/TrEMBL:Q3T1B2
    Q3T1B3 GenPept UniProtKB/TrEMBL:Q3T1B3
    Q8IX29.1 GenPept UniProtKB/Swiss-Prot:Q8IX29
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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