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RDH10 retinol dehydrogenase 10 (all-trans) [ Homo sapiens (human) ]

Gene ID: 157506, updated on 8-May-2016
Official Symbol
RDH10provided by HGNC
Official Full Name
retinol dehydrogenase 10 (all-trans)provided by HGNC
Primary source
HGNC:HGNC:19975
See related
Ensembl:ENSG00000121039 HPRD:07605; MIM:607599; Vega:OTTHUMG00000164492
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDR16C4
Summary
This gene encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor. Studies in mice suggest that this protein is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. [provided by RefSeq, Dec 2011]
Orthologs
Location:
8q21.11
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (73294602..73325285)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (74206837..74237520)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene chromosome 8 open reading frame 89 Neighboring gene family with sequence similarity 213 member A pseudogene Neighboring gene uncharacterized LOC105375900 Neighboring gene RDH10 antisense RNA 1 Neighboring gene ribosomal protein L7 Neighboring gene uncharacterized LOC105375899 Neighboring gene STAU2 antisense RNA 1 Neighboring gene staufen double-stranded RNA binding protein 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NADP-retinol dehydrogenase activity TAS
Traceable Author Statement
more info
 
retinol dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
retinol dehydrogenase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
bud elongation involved in lung branching IEA
Inferred from Electronic Annotation
more info
 
ear development IEA
Inferred from Electronic Annotation
more info
 
embryonic camera-type eye development IEA
Inferred from Electronic Annotation
more info
 
embryonic forelimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic viscerocranium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
gonad development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
metanephros development IEA
Inferred from Electronic Annotation
more info
 
neural crest cell development IEA
Inferred from Electronic Annotation
more info
 
nose development IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
primary lung bud formation IEA
Inferred from Electronic Annotation
more info
 
retinal metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
retinoic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
retinoid metabolic process TAS
Traceable Author Statement
more info
 
retinol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
retinol metabolic process IEA
Inferred from Electronic Annotation
more info
 
visual perception IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell body IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
NOT nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
retinol dehydrogenase 10
Names
short chain dehydrogenase/reductase family 16C member 4
short chain dehydrogenase/reductase family 16C, member 4
NP_742034.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172037.4NP_742034.1  retinol dehydrogenase 10

    See identical proteins and their annotated locations for NP_742034.1

    Status: REVIEWED

    Source sequence(s)
    AC111149, AF456765, BC067131, BM472905, BM804062, BM979260, CD110145
    Consensus CDS
    CCDS6213.1
    UniProtKB/Swiss-Prot
    Q8IZV5
    UniProtKB/TrEMBL
    A0A024R7X6
    Related
    ENSP00000240285, OTTHUMP00000226821, ENST00000240285, OTTHUMT00000378982
    Conserved Domains (2) summary
    cd05339
    Location:38307
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    COG0300
    Location:35304
    DltE; Short-chain dehydrogenase [General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    73294602..73325285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517466.1XP_011515768.1  

    UniProtKB/TrEMBL
    E5RK48
    Related
    ENSP00000428132, OTTHUMP00000226823, ENST00000519380, OTTHUMT00000378985
    Conserved Domains (1) summary
    cd05339
    Location:1142
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    74259535..74290179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)