Format

Send to:

Choose Destination

CDCA2 cell division cycle associated 2 [ Homo sapiens (human) ]

Gene ID: 157313, updated on 26-May-2016
Official Symbol
CDCA2provided by HGNC
Official Full Name
cell division cycle associated 2provided by HGNC
Primary source
HGNC:HGNC:14623
See related
Ensembl:ENSG00000184661 HPRD:13014; Vega:OTTHUMG00000099429
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPP1R81; Repo-Man
Summary
This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in cancer progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Orthologs
Location:
8p21.2
Exon count:
19
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (25458574..25511308)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (25316275..25365425)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene gonadotropin releasing hormone 1 Neighboring gene potassium channel tetramerization domain containing 9 Neighboring gene uncharacterized LOC105379333 Neighboring gene uncharacterized LOC105379332

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ25804, MGC129906, MGC129907

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
cell division cycle-associated protein 2
Names
protein phosphatase 1, regulatory subunit 81
recruits PP1 onto mitotic chromatin at anaphase protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317906.1NP_001304835.1  cell division cycle-associated protein 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) retains a 5' intron resulting in a distinct 5' UTR and the use of an alternate translation start site compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to variant 1.
    Source sequence(s)
    AA678348, AI022757, AK292505, AL833396, DB093475
    UniProtKB/Swiss-Prot
    Q69YH5
    UniProtKB/TrEMBL
    A8K8Z0, E9PEI0
    Conserved Domains (1) summary
    pfam15276
    Location:373435
    PP1_bind; Protein phosphatase 1 binding
  2. NM_001317907.1NP_001304836.1  cell division cycle-associated protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AA678348, AI022757, AK292505, AK299278, AL833396, DB093475
    UniProtKB/Swiss-Prot
    Q69YH5
    UniProtKB/TrEMBL
    A8K8Z0, B7Z5Q5
    Conserved Domains (1) summary
    pfam15276
    Location:388450
    PP1_bind; Protein phosphatase 1 binding
  3. NM_152562.3NP_689775.2  cell division cycle-associated protein 2 isoform 1

    See identical proteins and their annotated locations for NP_689775.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA678348, AI022757, AK299278, AL833396, BC015691, DB093475
    Consensus CDS
    CCDS6049.1
    UniProtKB/Swiss-Prot
    Q69YH5
    UniProtKB/TrEMBL
    B7Z5Q5
    Related
    ENSP00000328228, OTTHUMP00000125276, ENST00000330560, OTTHUMT00000216891
    Conserved Domains (1) summary
    pfam15276
    Location:388450
    PP1_bind; Protein phosphatase 1 binding

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    25458574..25511308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544417.1XP_011542719.1  

    See identical proteins and their annotated locations for XP_011542719.1

    Conserved Domains (1) summary
    pfam15276
    Location:417479
    PP1_bind; Protein phosphatase 1 binding
  2. XM_011544416.1XP_011542718.1  

    See identical proteins and their annotated locations for XP_011542718.1

    Conserved Domains (1) summary
    pfam15276
    Location:417479
    PP1_bind; Protein phosphatase 1 binding
  3. XM_011544415.1XP_011542717.1  

    See identical proteins and their annotated locations for XP_011542717.1

    Conserved Domains (1) summary
    pfam15276
    Location:417479
    PP1_bind; Protein phosphatase 1 binding
  4. XM_006716294.1XP_006716357.1  

    Conserved Domains (1) summary
    pfam15276
    Location:393455
    PP1_bind; Protein phosphatase 1 binding
  5. XM_011544420.1XP_011542722.1  

    Conserved Domains (1) summary
    pfam15276
    Location:417479
    PP1_bind; Protein phosphatase 1 binding
  6. XM_011544418.1XP_011542720.1  

    Conserved Domains (1) summary
    pfam15276
    Location:412474
    PP1_bind; Protein phosphatase 1 binding
  7. XM_005273418.2XP_005273475.1  

    Conserved Domains (1) summary
    pfam15276
    Location:388450
    PP1_bind; Protein phosphatase 1 binding
  8. XM_011544419.1XP_011542721.1  

    Conserved Domains (1) summary
    pfam15276
    Location:252314
    PP1_bind; Protein phosphatase 1 binding

RNA

  1. XR_949377.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    25517979..25566826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)