ADRBK2 adrenergic, beta, receptor kinase 2 [Homo sapiens] - Gene

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Summary

Official Symbol: ADRBK2provided by HGNC
Official Full Name: adrenergic, beta, receptor kinase 2provided by HGNC
Primary source: HGNC:290
See related: Ensembl:ENSG00000100077; HPRD:00183; MIM:109636; Vega:OTTHUMG00000150280
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GRK3; BARK2
Summary: The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 22q12.1

Sequence :: Chromosome: 22; NC_000022.10 (25960861..26125259)

See ADRBK2 in Epigenomics, MapViewer

Chromosome 22 - NC_000022.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
mRNA levels for GRK3 were inversely correlated with systolic and diastolic blood pressure (day, night and 24 h), which suggests a protective role for GRK3 in the regulation of human blood pressure
Title: beta-Adrenoceptor and GRK3 expression in human lymphocytes is related to blood pressure and urinary albumin excretion.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
we found no evidence of altered levels of acetylated histone H3 at the affected allele compared to the common allele
Title: Allele specific analysis of the ADRBK2 gene in lymphoblastoid cells from bipolar disorder patients.
The results of this study suggested that there were statistically significant decreases in protein and mRNA levels of G-protein subunits beta and gamma and of GRK3 in brain of bipolar disorder.
Title: Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients.
The G-384A variant may alter binding of Sp1/Sp4 transcription factors resulting in an increase in gene transcription and an increase in vulnerability to bipolar disorder.
Title: Promoter variant in the GRK3 gene associated with bipolar disorder alters gene expression.
role for GRK3 in regulating CXCR4 attenuation and have provided a mechanistic link between the GRK3 pathway and the CXCR4-related WHIM(WT) disorder.
Title: Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling.
Observational study of gene-disease association. (HuGE Navigator)
Title: A large-scale candidate gene association study of age at menarche and age at natural menopause.
Dysregulation in GRK3 expression alters signaling desensitization and thereby predisposes to the development of bipolar disease.
Title: Further evidence for association of GRK3 to bipolar disorder suggests a second disease mutation.
No support for a major role for GRK3 gene promoter variants in cocaine addiction.
Title: Association analysis of GRK3 gene promoter variants in cocaine abuse.

Submit: New GeneRIF Correction See all (13)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P35626	P30556	AGTR1	HPRD	PubMed
P35626	P30411	BDKRB2	HPRD	PubMed
P35626	P51679	CCR4	HPRD	PubMed
P35626	P51681	CCR5	HPRD	PubMed
P35626	P61073	CXCR4	HPRD	PubMed
P35626	Q9Y2X7	GIT1	HPRD	PubMed
P35626	P35372	OPRM1	HPRD	PubMed
BioGRID:106666	BioGRID:107638	CCR4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106666	BioGRID:113607	CXCR4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106666	BioGRID:118789	GIT1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106666	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
G-protein coupled receptor kinase activity	IEA Inferred from Electronic Annotation more info
beta-adrenergic receptor kinase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein kinase activity	TAS Traceable Author Statement more info	PubMed
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
protein phosphorylation	TAS Traceable Author Statement more info	PubMed
receptor internalization	IDA Inferred from Direct Assay more info
signal transduction	IEA Inferred from Electronic Annotation more info
termination of G-protein coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: beta-adrenergic receptor kinase 2

Names: beta-adrenergic receptor kinase 2; beta-ARK-2; G-protein-coupled receptor kinase 3

NP_005151.2

EC 2.7.11.15

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005160.3 → NP_005151.2 beta-adrenergic receptor kinase 2

Status: REVIEWED

Source sequence(s)

AL022329, BC036797, BC063545, BX387339

Consensus CDS

CCDS13832.1

UniProtKB/Swiss-Prot

P35626

UniProtKB/TrEMBL

Q8N433

Related

ENSP00000317578, OTTHUMP00000196857, ENST00000324198, OTTHUMT00000317296

Conserved Domains (5) summary

cd05606
Location:196 – 473
Blast Score: 1571

STKc_beta_ARK; Catalytic domain of the Protein Serine/Threonine Kinase, beta-adrenergic receptor kinase

cd08747
Location:30 – 186
Blast Score: 812

RGS_GRK2_GRK3; Regulator of G protein signaling domain (RGS) found in G protein-coupled receptor kinase 2 (GRK2) and G protein-coupled receptor kinase 3 (GRK3)

pfam00069
Location:191 – 453
Blast Score: 719

Pkinase; Protein kinase domain

cl00273
Location:557 – 669
Blast Score: 409

PH-like; Pleckstrin homology-like domain

cl11395
Location:454 – 520
Blast Score: 115

Pkinase_C; Protein kinase C terminal domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000022.10 Reference GRCh37.p5 Primary Assembly

Range

25960861..26125259

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000154.1 Alternate HuRef

Range

8764181..9073051

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL022329.9	CAB45657.1
genomic	CH471095.1	EAW59698.1
		EAW59699.1
		EAW59700.1
		EAW59701.1
mRNA	AK055687.1	None
mRNA	AK058103.1	None
mRNA	AK123767.1	None
mRNA	AK124922.1	None
mRNA	AK292234.1	BAF84923.1
mRNA	AK310398.1	None
mRNA	BC021221.2	None
mRNA	BC029563.1	None
mRNA	BC036797.1	AAH36797.1
mRNA	BC063545.1	None
mRNA	BX387339.2	None
mRNA	X69117.1	CAA48870.1