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vpu p16 [ Human immunodeficiency virus 1 ]

Gene ID: 155945, updated on 5-Aug-2014
Gene symbol
vpu
Gene description
p16
Locus tag
HIV1gp7
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Human immunodeficiency virus 1 (gb-acronym: HIV-1)
Lineage
Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Primate lentivirus group
Sequence:
NC_001802.1 (5608..5856)

NC_001802.1Genomic Context describing neighboring genes Neighboring gene Gag-Pol Neighboring gene Pr55(Gag) Neighboring gene p23 Neighboring gene p15 Neighboring gene p14 Neighboring gene p19 Neighboring gene gp160; envelope glycoprotein Neighboring gene minus-strand-encoded antisense protein of unknown function; region is highly conserved and likely analogous to the HTLV-1 encoded, HBZ, a nuclear basic region leucine zipper (b-ZIP) protein Neighboring gene p27

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
long-chain-fatty-acid--CoA ligase 3 ACSL3 interacts with PubMed
AP-2 complex subunit mu isoform a AP2M1 interacts with PubMed
DNA dC->dU-editing enzyme APOBEC-3F isoform a APOBEC3F inhibits PubMed
DNA dC->dU-editing enzyme APOBEC-3G APOBEC3G inhibits PubMed
apolipoprotein L1 isoform a precursor APOL1 downregulated by PubMed
brefeldin A-inhibited guanine nucleotide-exchange protein 1 ARFGEF1 interacts with PubMed
brefeldin A-inhibited guanine nucleotide-exchange protein 2 ARFGEF2 interacts with PubMed
ATPase family AAA domain-containing protein 3A isoform 1 ATAD3A interacts with PubMed
ATPase family AAA domain-containing protein 3B ATAD3B interacts with PubMed
cyclic AMP-dependent transcription factor ATF-4 ATF4 stabilizes PubMed
plasma membrane calcium-transporting ATPase 1 isoform 1b ATP2B1 interacts with PubMed
ATP synthase subunit beta, mitochondrial precursor ATP5B interacts with PubMed
ATP synthase subunit delta, mitochondrial precursor ATP5D interacts with PubMed
ATP synthase F(0) complex subunit B1, mitochondrial precursor ATP5F1 interacts with PubMed
ATP synthase subunit d, mitochondrial isoform a ATP5H interacts with PubMed
ATP synthase-coupling factor 6, mitochondrial isoform a precursor ATP5J interacts with PubMed
ATP synthase subunit O, mitochondrial precursor ATP5O interacts with PubMed
ataxin-10 isoform 1 ATXN10 interacts with PubMed
aurora kinase A AURKA binds PubMed
apoptosis regulator BAX isoform beta BAX upregulates PubMed
bcl-2-related protein A1 isoform 1 BCL2A1 downregulates PubMed
bcl-2-like protein 1 isoform 1 BCL2L1 downregulates PubMed
bone marrow stromal antigen 2 precursor BST2 downregulates PubMed
BST2 inhibits PubMed
BST2 inhibits PubMed
BST2 interacts with PubMed
BST2 relocalizes PubMed
BST2 inhibits PubMed
BST2 downregulates PubMed
BST2 inhibits PubMed
BST2 downregulates PubMed
BST2 interacts with PubMed
BST2 interacts with PubMed
BST2 interacts with PubMed
BST2 interacts with PubMed
BST2 inhibited by PubMed
BST2 interacts with PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 inhibits PubMed
BST2 inhibits PubMed
BST2 downregulates PubMed
BST2 interacts with PubMed
BST2 co-localizes with PubMed
BST2 interacts with PubMed
BST2 degrades PubMed
BST2 degrades PubMed
BST2 degrades PubMed
BST2 induces ubiquitination of PubMed
BST2 relocalizes PubMed
BST2 downregulates PubMed
BST2 inhibits PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 interacts with PubMed
BST2 interacts with PubMed
BST2 inhibits PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 inhibits PubMed
BST2 downregulates PubMed
BST2 relocalizes PubMed
BST2 interacts with PubMed
BST2 induces ubiquitination of PubMed
BST2 interacts with PubMed
BST2 inhibits PubMed
BST2 inhibits PubMed
BST2 interacts with PubMed
BST2 modulates PubMed
BST2 inhibits PubMed
BST2 binds PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 inhibits PubMed
BST2 downregulates PubMed
BST2 interacts with PubMed
BST2 inhibits PubMed
BST2 interacts with PubMed
BST2 modulates PubMed
BST2 downregulates PubMed
BST2 degrades PubMed
BST2 interacts with PubMed
BST2 downregulates PubMed
BST2 interacts with PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 interacts with PubMed
BST2 interacts with PubMed
BST2 downregulates PubMed
BST2 interacts with PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 downregulates PubMed
BST2 inhibits PubMed
BST2 disrupts PubMed
BST2 binds PubMed
BST2 downregulates PubMed
F-box/WD repeat-containing protein 1A isoform 2 BTRC binds PubMed
BTRC binds PubMed
BTRC interacts with PubMed
BTRC interacts with PubMed
BTRC interacts with PubMed
BTRC competes with PubMed
BTRC interacts with PubMed
BTRC interacts with PubMed
BTRC interacts with PubMed
BTRC inhibits PubMed
BTRC interacts with PubMed
BTRC interacts with PubMed
BTRC inhibits PubMed
BTRC recruits PubMed
BTRC binds PubMed
caspase-3 preproprotein CASP3 activates PubMed
T-cell surface glycoprotein CD1c precursor CD1C downregulates PubMed
antigen-presenting glycoprotein CD1d precursor CD1D downregulates PubMed
CD1D inhibits PubMed
CD1D downregulates PubMed
T-cell surface glycoprotein CD3 zeta chain isoform 1 precursor CD247 interacts with PubMed
T-cell surface glycoprotein CD3 delta chain isoform A precursor CD3D interacts with PubMed
T-cell surface glycoprotein CD3 epsilon chain precursor CD3E interacts with PubMed
T-cell surface glycoprotein CD3 gamma chain precursor CD3G interacts with PubMed
T-cell surface glycoprotein CD4 isoform 1 precursor CD4 binds PubMed
CD4 interacts with PubMed
CD4 interacts with PubMed
CD4 induces accumulation of PubMed
CD4 interacts with PubMed
CD4 downregulates PubMed
CD4 binds PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 interacts with PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 interacts with PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 downregulates PubMed
CD4 inhibited by PubMed
CD4 degrades PubMed
CD4 regulates PubMed
CD4 degrades PubMed
CD4 degrades PubMed
tumor necrosis factor receptor superfamily member 5 isoform 1 precursor CD40 upregulates PubMed
HLA class II histocompatibility antigen gamma chain isoform b CD74 interacts with PubMed
M-phase inducer phosphatase 1 isoform a CDC25A stabilizes PubMed
cadherin-1 preproprotein CDH1 interacts with PubMed
centrosomal protein of 57 kDa isoform a CEP57 interacts with PubMed
ceramide synthase 2 CERS2 interacts with PubMed
cysteine and histidine-rich domain-containing protein 1 isoform a CHORDC1 interacts with PubMed
contactin-associated protein 1 precursor CNTNAP1 interacts with PubMed
casein kinase I isoform gamma-3 isoform 1 CSNK1G3 binds PubMed
casein kinase II subunit alpha isoform a CSNK2A1 phosphorylated by PubMed
CSNK2A1 phosphorylated by PubMed
casein kinase II subunit alpha' CSNK2A2 phosphorylated by PubMed
CSNK2A2 phosphorylated by PubMed
casein kinase II subunit beta isoform 1 CSNK2B phosphorylated by PubMed
CSNK2B phosphorylated by PubMed
CSNK2B phosphorylated by PubMed
catenin beta-1 CTNNB1 stabilizes PubMed
CTNNB1 interacts with PubMed
CTNNB1 stabilizes PubMed
cullin-1 CUL1 interacts with PubMed
sn1-specific diacylglycerol lipase beta isoform 1 DAGLB interacts with PubMed
dynamin-2 isoform 3 DNM2 inhibited by PubMed
enhancer of mRNA-decapping protein 4 EDC4 interacts with PubMed
early endosome antigen 1 EEA1 co-localizes with PubMed
interferon-induced, double-stranded RNA-activated protein kinase isoform a EIF2AK2 inhibits PubMed
tumor necrosis factor receptor superfamily member 6 isoform 1 precursor FAS interacts with PubMed
F-box/WD repeat-containing protein 11 isoform A FBXW11 interacts with PubMed
FBXW11 interacts with PubMed
flotillin-1 FLOT1 co-localizes with PubMed
Golgin subfamily A member 4 isoform 2 GOLGA4 co-localizes with PubMed
glycogen synthase kinase-3 beta isoform 1 GSK3B binds PubMed
trifunctional enzyme subunit alpha, mitochondrial precursor HADHA interacts with PubMed
trifunctional enzyme subunit beta, mitochondrial isoform 1 precursor HADHB interacts with PubMed
hepatocyte growth factor-regulated tyrosine kinase substrate HGS interacts with PubMed
HGS cooperates with PubMed
HLA class I histocompatibility antigen, A-1 alpha chain precursor HLA-A regulated by PubMed
HLA-A downregulates PubMed
major histocompatibility complex, class I, B precursor HLA-B regulated by PubMed
HLA-B downregulates PubMed
HLA class I histocompatibility antigen, Cw-1 alpha chain precursor HLA-C regulated by PubMed
HLA-C downregulates PubMed
HLA class II histocompatibility antigen, DM alpha chain precursor HLA-DMA modulates PubMed
HLA class II histocompatibility antigen, DM beta chain precursor HLA-DMB modulates PubMed
HLA class II histocompatibility antigen, DO alpha chain precursor HLA-DOA modulates PubMed
HLA class II histocompatibility antigen, DO beta chain precursor HLA-DOB modulates PubMed
HLA class II histocompatibility antigen, DP alpha 1 chain precursor HLA-DPA1 modulates PubMed
HLA class II histocompatibility antigen, DP beta 1 chain precursor HLA-DPB1 modulates PubMed
HLA class II histocompatibility antigen, DQ alpha 1 chain precursor HLA-DQA1 modulates PubMed
HLA class II histocompatibility antigen, DQ alpha 2 chain precursor HLA-DQA2 modulates PubMed
HLA class II histocompatibility antigen, DQ beta 1 chain isoform 1 precursor HLA-DQB1 modulates PubMed
HLA class II histocompatibility antigen, DQ beta 2 chain precursor HLA-DQB2 modulates PubMed
HLA class II histocompatibility antigen, DR alpha chain precursor HLA-DRA modulates PubMed
major histocompatibility complex, class II, DR beta 1 precursor HLA-DRB1 modulates PubMed
major histocompatibility complex, class II, DR beta 3 precursor HLA-DRB3 modulates PubMed
major histocompatibility complex, class II, DR beta 4 precursor HLA-DRB4 modulates PubMed
major histocompatibility complex, class II, DR beta 5 precursor HLA-DRB5 modulates PubMed
HLA class I histocompatibility antigen, alpha chain E precursor HLA-E regulated by PubMed
HLA class I histocompatibility antigen, alpha chain F isoform 2 precursor HLA-F regulated by PubMed
HLA class I histocompatibility antigen, alpha chain G precursor HLA-G regulated by PubMed
estradiol 17-beta-dehydrogenase 12 HSD17B12 interacts with PubMed
intercellular adhesion molecule 2 precursor ICAM2 interacts with PubMed
interferon-induced protein with tetratricopeptide repeats 1 isoform 1 IFIT1 inhibits PubMed
interferon-induced protein with tetratricopeptide repeats 2 IFIT2 inhibits PubMed
interferon-induced protein with tetratricopeptide repeats 3 isoform a IFIT3 inhibits PubMed
interferon alpha-1/13 precursor IFNA1 inhibited by PubMed
IFNA1 interacts with PubMed
IFNA1 inhibits PubMed
interferon alpha-10 precursor IFNA10 interacts with PubMed
IFNA10 inhibits PubMed
IFNA13 interacts with PubMed
IFNA13 inhibits PubMed
interferon alpha-14 precursor IFNA14 interacts with PubMed
IFNA14 inhibits PubMed
interferon alpha-16 precursor IFNA16 interacts with PubMed
IFNA16 inhibits PubMed
interferon alpha-17 precursor IFNA17 interacts with PubMed
IFNA17 inhibits PubMed
interferon alpha-2 precursor IFNA2 interacts with PubMed
IFNA2 inhibits PubMed
interferon alpha-21 precursor IFNA21 interacts with PubMed
IFNA21 inhibits PubMed
interferon alpha-4 precursor IFNA4 interacts with PubMed
IFNA4 inhibits PubMed
interferon alpha-5 precursor IFNA5 interacts with PubMed
IFNA5 inhibits PubMed
interferon alpha-6 precursor IFNA6 interacts with PubMed
IFNA6 inhibits PubMed
interferon alpha-7 precursor IFNA7 interacts with PubMed
IFNA7 inhibits PubMed
interferon alpha-8 precursor IFNA8 interacts with PubMed
IFNA8 inhibits PubMed
interferon beta precursor IFNB1 inhibits PubMed
IFNB1 inhibited by PubMed
importin-9 IPO9 interacts with PubMed
interferon regulatory factor 3 isoform 1 IRF3 co-localizes with PubMed
IRF3 interacts with PubMed
IRF3 complexes with PubMed
ubiquitin-like protein ISG15 precursor ISG15 inhibits PubMed
interferon-stimulated gene 20 kDa protein ISG20 inhibits PubMed
potassium channel subfamily K member 3 KCNK3 interacts with PubMed
KCNK3 interacts with PubMed
killer cell immunoglobulin-like receptor 2DL2 precursor KIR2DL2 inhibits PubMed
NKG2-D type II integral membrane protein KLRK1 downregulates PubMed
lysosome-associated membrane glycoprotein 1 precursor LAMP1 co-localizes with PubMed
lysosome-associated membrane glycoprotein 2 isoform A precursor LAMP2 co-localizes with PubMed
leucine-rich PPR motif-containing protein, mitochondrial precursor LRPPRC interacts with PubMed
moesin MSN interacts with PubMed
interferon-induced GTP-binding protein Mx1 isoform a MX1 inhibits PubMed
condensin-2 complex subunit D3 NCAPD3 interacts with PubMed
NEDD8 precursor NEDD8 interacts with PubMed
nuclear factor NF-kappa-B p105 subunit isoform 1 NFKB1 inhibits PubMed
NFKB1 inhibits PubMed
NFKB1 inhibits PubMed
NFKB1 inhibits PubMed
NF-kappa-B inhibitor alpha NFKBIA stabilizes PubMed
serine/threonine-protein kinase NLK NLK binds PubMed
nuclear protein localization protein 4 homolog NPLOC4 cooperates with PubMed
serine/threonine-protein kinase N2 PKN2 binds PubMed
serine/threonine-protein kinase PLK1 PLK1 binds PubMed
serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA dephosphorylated by PubMed
serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB dephosphorylated by PubMed
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform PPP2R1A dephosphorylated by PubMed
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform a PPP2R5E interacts with PubMed
prolactin regulatory element-binding protein PREB interacts with PubMed
DNA-dependent protein kinase catalytic subunit isoform 1 PRKDC interacts with PubMed
prostaglandin E synthase 3 isoform a PTGES3 interacts with PubMed
poliovirus receptor isoform alpha precursor PVR downregulates PubMed
ran-specific GTPase-activating protein isoform 2 RANBP1 interacts with PubMed
RNA-binding motif protein, Y chromosome, family 1 member A1 RBMY1A1 interacts with PubMed
transcription factor p65 isoform 1 RELA inhibited by PubMed
E3 ubiquitin-protein ligase RNF115 RNF115 inhibits PubMed
E3 ubiquitin-protein ligase RNF213 isoform 2 RNF213 interacts with PubMed
ribosomal protein S6 kinase alpha-5 isoform a RPS6KA5 binds PubMed
radical S-adenosyl methionine domain-containing protein 2 RSAD2 inhibits PubMed
reticulon-3 isoform a RTN3 interacts with PubMed
reticulon-4 isoform C RTN4 interacts with PubMed
secretory carrier-associated membrane protein 3 isoform 1 SCAMP3 interacts with PubMed
SCY1-like protein 2 SCYL2 inhibited by PubMed
SCYL2 inhibited by PubMed
SCYL2 inhibited by PubMed
SCYL2 binds PubMed
sphingosine-1-phosphate lyase 1 SGPL1 interacts with PubMed
small glutamine-rich tetratricopeptide repeat-containing protein alpha SGTA binds PubMed
SGTA interacts with PubMed
S-phase kinase-associated protein 1 isoform a SKP1 interacts with PubMed
SLAM family member 6 isoform 2 precursor SLAMF6 modulates PubMed
SLAMF6 modulates PubMed
SLAMF6 downregulates PubMed
SLAMF6 interacts with PubMed
SLAMF6 downregulates PubMed
SLAMF6 binds PubMed
long-chain fatty acid transport protein 4 SLC27A4 interacts with PubMed
SRA stem-loop-interacting RNA-binding protein, mitochondrial isoform 1 precursor SLIRP interacts with PubMed
zinc finger protein SNAI1 SNAI1 upregulates PubMed
SNAI1 upregulates PubMed
zinc finger protein SNAI2 SNAI2 upregulates PubMed
SNAI2 upregulates PubMed
clathrin coat assembly protein AP180 isoform a SNAP91 inhibited by PubMed
signal transducer and activator of transcription 1-alpha/beta isoform alpha STAT1 inhibits PubMed
TBC1 domain family member 15 isoform 1 TBC1D15 interacts with PubMed
protein TBRG4 isoform 1 TBRG4 interacts with PubMed
transferrin receptor protein 1 TFRC co-localizes with PubMed
trans-Golgi network integral membrane protein 2 isoform 1 precursor TGOLN2 co-localizes with PubMed
transmembrane protein 192 TMEM192 interacts with PubMed
type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 2 TMEM55B interacts with PubMed
tumor necrosis factor TNF inhibits PubMed
cellular tumor antigen p53 isoform a TP53 upregulates PubMed
TP53 stabilizes PubMed
TNF receptor-associated factor 1 isoform a TRAF1 downregulates PubMed
tripartite motif-containing protein 5 isoform alpha TRIM5 inhibits PubMed
testis-specific serine/threonine-protein kinase 2 TSSK2 binds PubMed
ubiquitin-associated protein 1 isoform 1 UBAP1 requires PubMed
ubiquitin fusion degradation protein 1 homolog isoform A UFD1L cooperates with PubMed
vascular cell adhesion protein 1 isoform a precursor VCAM1 upregulates PubMed
transitional endoplasmic reticulum ATPase VCP cooperates with PubMed
VCP cooperates with PubMed
vacuolar protein sorting-associated protein 4A VPS4A cooperates with PubMed
vacuolar protein sorting-associated protein 4B VPS4B cooperates with PubMed
exportin-1 XPO1 interacts with PubMed
exportin-4 XPO4 interacts with PubMed
exportin-5 XPO5 interacts with PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description
Preferred Names
p16
Names
Vpu
NP_057855.1
  • Vpu and gp160 are translated from different reading frames of the same bicistronic mRNA

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001802.1 

    Range
    5608..5856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_057855.1 Vpu [Human immunodeficiency virus 1]

    See proteins identical to NP_057855.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9WB91
    Conserved Domains (1) summary
    pfam00558
    Location:2379
    Blast Score: 168
    Vpu; Vpu protein