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    Hspb1 heat shock protein 1 [ Mus musculus ]

    Gene ID: 15507, updated on 19-May-2012
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    Summary

    Official Symbol
    Hspb1provided by MGI
    Official Full Name
    heat shock protein 1provided by MGI
    Primary source
    MGI:96240
    See related
    Ensembl:ENSMUSG00000004951; Vega:OTTMUSG00000024281
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    27kDa; Hsp25
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    Genomic context

    Location :
    5 G2; 5 76.0 cM
    Sequence :
    Chromosome: 5; NC_000071.6 (135887919..135889563)
    See Hspb1 in Epigenomics, MapViewer

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene malate dehydrogenase 2, NAD (mitochondrial) Neighboring gene serine/arginine repetitive matrix 3 Neighboring gene predicted gene, 19359 Neighboring gene uncharacterized LOC100861974 Neighboring gene predicted gene, 19383 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Silencing Hsp25/Hsp27 gene expression augments proteasome activity and increases CD8+ T-cell-mediated tumor killing and memory responses. Nagaraja GM, et al. Cancer Prev Res (Phila), 2012 Jan. PMID 22185976.
    2. Absolute amounts and diffusibility of HSP72, HSP25, and αB-crystallin in fast- and slow-twitch skeletal muscle fibers of rat. Larkins NT, et al. Am J Physiol Cell Physiol, 2012 Jan. PMID 21975426.
    3. HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes. Ke L, et al. PLoS One, 2011. PMID 21731611.
    4. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Lachke SA, et al. Science, 2011 Mar 25. PMID 21436445.
    5. Regulation by heat shock protein 27 of osteocalcin synthesis in osteoblasts. Kato K, et al. Endocrinology, 2011 May. PMID 21427224.

    See all (90) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Silencing Hsp25/Hsp27 gene expression augments proteasome activity and increases CD8+ T-cell-mediated tumor killing and memory responses
      Title: Silencing Hsp25/Hsp27 gene expression augments proteasome activity and increases CD8+ T-cell-mediated tumor killing and memory responses.
    2. The absolute amounts of HSP25 in extensor digitorum longus and soleus muscles are similar in both mouse and rat.
      Title: Absolute amounts and diffusibility of HSP72, HSP25, and αB-crystallin in fast- and slow-twitch skeletal muscle fibers of rat.
    3. Overexpression of HSPB1, as well as HSPB6, HSPB7 and HSPB8 independently protect against tachycardia remodeling by attenuation of the RhoA GTPase pathway at different levels.
      Title: HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes.
    4. Data show that osteocalcin synthesis was significantly reduced in the stable HSP27-transfected MC3T3-E1 cells and normal human osteoblasts.
      Title: Regulation by heat shock protein 27 of osteocalcin synthesis in osteoblasts.
    5. Members of seven virus families modulate Hsp25 or Hsp27 expression in a variety of cell types, suggesting that Hsp25 participation in the antiviral response may be widespread.
      Title: Proteomic analysis reveals virus-specific Hsp25 modulation in cardiac myocytes.
    6. Data suggest that heat shock protein 25 plays a neuroprotective role in the flocculonodular region of the lurcher mutant mouse cerebellum.
      Title: Heat shock protein 25 expression and preferential Purkinje cell survival in the lurcher mutant mouse cerebellum.
    7. Heat shock protein 27 is upregulated in response to gastroduodenal reflux in BALB C mouse.
      Title: Heat shock protein 27: induction by gastroduodenal reflux in vivo and augmentation of human esophageal mucosal cell growth in vitro.
    8. Mechanism of downregulation of Akt activation in 6-mo streptozotocin diabetic kidneys was attributed to decreased Akt-heat shock protein (Hsp) 25, Akt-p38 interaction, and decreased PTEN activity.
      Title: Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy.
    9. MAPK signals play important roles in incisor formation, differentiation, and development by mediating Hsp25 signaling.
      Title: MAPK mediates Hsp25 signaling in incisor development.
    10. p38 MAP kinase and its downstream effector MK2 mediate lung permeability in ventilator associated lung injury by regulating HSP25 phosphorylation and actin cytoskeletal remodeling.
      Title: Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury.
    Submit: New GeneRIF Correction See all (39)
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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_038588.1 NP_112442.2 Hspa8    BIND  PubMed hsc70 interacts with hsp25. 
    NP_038588.1 NP_038587.1 Hsph1    BIND  PubMed hsp110 interacts with hsp25. 
    BioGRID:200449 BioGRID:202197 Prkcd    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:200449 BioGRID:204403 Ubc    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
      FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • IL-6 signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 signaling Pathway, organism-specific biosystem
      IL-6 signaling Pathway
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem
      TNF-alpha NF-kB Signaling Pathway
    • VEGF signaling pathway, organism-specific biosystem (from KEGG)
      VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • VEGF signaling pathway, conserved biosystem (from KEGG)
      VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
    • p38 MAPK Signaling Pathway (BioCarta), organism-specific biosystem (from WikiPathways)
      p38 MAPK Signaling Pathway (BioCarta), organism-specific biosystemp38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases...

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein kinase C binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein kinase C inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    cellular response to vascular endothelial growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    endothelial cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of interleukin-1 beta production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of tumor necrosis factor biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of I-kappaB kinase/NF-kappaB cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to unfolded protein NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    contractile fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    insoluble fraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    intracellular IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    soluble fraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    heat shock protein beta-1
    Names
    heat shock protein beta-1
    p25
    HSP 25
    HSP 27
    truncated hsp25
    heat shock 25 kDa protein
    heat shock 27 kDa protein
    heat shock 27kDa protein 1
    heat shock protein, 25 kDa
    growth-related 25 kDa protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013560.2 → NP_038588.2  heat shock protein beta-1

      Status: VALIDATED

      Source sequence(s)
      AA013886, AV458710, BC099463
      Consensus CDS
      CCDS39320.1
      UniProtKB/Swiss-Prot
      P14602
      UniProtKB/TrEMBL
      Q545F4
      Related
      ENSMUSP00000005077, OTTMUSP00000028918, ENSMUST00000005077, OTTMUST00000059461
      Conserved Domains (1) summary
      cd06475
      Location:88 – 173
      Blast Score: 438
      ACD_HspB1_like; Alpha crystallin domain (ACD) found in mammalian small (s)heat shock protein (Hsp)-27 (also denoted HspB1 in human) and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally ...

    RefSeqs of Annotated Genomes: Build 38.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38 C57BL/6J

      Range
      135887919..135889563
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000027.1 Alternate Mm_Celera

      Range
      132896482..132898126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AC084162.3 (88881..90259) None C57BL/6J
    genomic CH466529.2 EDL19344.1 mixed
    genomic L07577.1 AAA37861.1
    genomic L11608.1 AAA37862.1
    genomic L11609.1 AAA37862.1
    mRNA AA013886.1 None C57BL/6J
    mRNA AF047377.1 AAD02432.1 C57Bl X CBA F1 hybrid
    mRNA AF047378.1 AAD02433.1 C57Bl X CBA F1 hybrid
    mRNA AK003119.1 BAB22579.1 C57BL/6J
    mRNA AK010663.1 BAB27099.1 C57BL/6J
    mRNA AK168927.1 BAE40740.1 C57BL/6J
    mRNA AV458710.1 None
    mRNA BC018257.1 AAH18257.1 FVB/N
    mRNA BC090388.1 None NMRI
    mRNA BC099463.1 AAH99463.1
    mRNA U03560.1 AAA18335.1
    mRNA U03561.1 AAA18336.1
    mRNA U03562.1 AAA18337.1
    mRNA X14686.1 CAB37341.1
    mRNA X14687.1 CAA32818.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14602.3 GenPept UniProtKB/Swiss-Prot:P14602
    Q545F4 GenPept UniProtKB/TrEMBL:Q545F4
    Q9Z2L3 GenPept UniProtKB/TrEMBL:Q9Z2L3
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
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