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AMOT angiomotin [ Homo sapiens (human) ]

Gene ID: 154796, updated on 8-May-2016
Official Symbol
AMOTprovided by HGNC
Official Full Name
angiomotinprovided by HGNC
Primary source
HGNC:HGNC:17810
See related
Ensembl:ENSG00000126016 HPRD:02327; MIM:300410; Vega:OTTHUMG00000022216
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Orthologs
Location:
Xq23
Exon count:
17
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (112774877..112840961, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (112018105..112084136, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene lipoma HMGIC fusion partner-like 1 Neighboring gene high mobility group box 3 pseudogene 30 Neighboring gene microRNA 4329 Neighboring gene uncharacterized LOC101928437 Neighboring gene peptidylprolyl isomerase H pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of angiomotin (AMOT) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed
Knockdown of Angiomotin (AMOT) by siRNA inhibits HIV-1 release and infectivity, but expression of AMOT-like protein 1 and AMOT-like protein 2 can rescue HIV-1 Gag release PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Angiomotin (AMOT) depletion inhibits HIV-1 Gag release from cells, but expression of AMOT-like protein 1 and AMOT-like protein 2 can rescue HIV-1 Gag release PubMed
gag Angiomotin (AMOT) stimulates NEDD4L-dependent release of HIV-1 Gag delta PTAP/YP in a does-dependent manner from 293T, HeLa, and Jurkat cells PubMed
gag Angiomotin (AMOT), AMOT-like protein 1, and AMOT-like protein 2 bind directly and specifically to NEDD4L and HIV-1 Gag-delta p6 in protein pull-down experiments PubMed

Go to the HIV-1, Human Interaction Database

  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Hippo, organism-specific biosystem (from REACTOME)
    Signaling by Hippo, organism-specific biosystemHuman Hippo signaling is a network of reactions that regulates cell proliferation and apoptosis, centered on a three-step kinase cascade. The cascade was discovered by analysis of Drosophila mutation...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA1071

Gene Ontology Provided by GOA

Function Evidence Code Pubs
angiostatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
cell migration involved in gastrulation IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction assembly TAS
Traceable Author Statement
more info
PubMed 
cellular protein localization IDA
Inferred from Direct Assay
more info
PubMed 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
establishment of cell polarity involved in ameboidal cell migration IEA
Inferred from Electronic Annotation
more info
 
gastrulation with mouth forming second IEA
Inferred from Electronic Annotation
more info
 
hippo signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
hippo signaling TAS
Traceable Author Statement
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of vascular permeability IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell size TAS
Traceable Author Statement
more info
PubMed 
positive regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of stress fiber assembly TAS
Traceable Author Statement
more info
PubMed 
regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
actin filament IDA
Inferred from Direct Assay
more info
PubMed 
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 
stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
angiomotin
Names
angiomotin p130 isoform
angiomotin p80 isoform

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012628.1 RefSeqGene

    Range
    5001..70939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001113490.1NP_001106962.1  angiomotin isoform 1

    See identical proteins and their annotated locations for NP_001106962.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). The N-terminus of this isoform mediates association with cytoplasmic F-actin.
    Source sequence(s)
    AB028994, AF286598, AY987378
    Consensus CDS
    CCDS48154.1
    UniProtKB/Swiss-Prot
    Q4VCS5
    Related
    ENSP00000361027, ENST00000371959
    Conserved Domains (2) summary
    pfam12240
    Location:599808
    Angiomotin_C; Angiomotin C terminal
    cl12013
    Location:457638
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. NM_133265.2NP_573572.1  angiomotin isoform 2

    See identical proteins and their annotated locations for NP_573572.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. This difference results in translation initiation at a downstream ATG and an isoform (2) with a shorter N-terminus, compared to isoform 1. This isoform lacks the N-terminal extension present in isoform 1 that mediates association with cytoplasmic F-actin.
    Source sequence(s)
    AB028994, AF286598
    Consensus CDS
    CCDS14563.1
    UniProtKB/Swiss-Prot
    Q4VCS5
    Related
    ENSP00000305557, OTTHUMP00000023866, ENST00000304758, OTTHUMT00000057950
    Conserved Domains (1) summary
    pfam12240
    Location:190399
    Angiomotin_C; Angiomotin C terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    112774877..112840961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530875.1XP_011529177.1  

    See identical proteins and their annotated locations for XP_011529177.1

    UniProtKB/Swiss-Prot
    Q4VCS5
    Conserved Domains (2) summary
    pfam12240
    Location:599808
    Angiomotin_C; Angiomotin C terminal
    cl12013
    Location:457638
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. XM_005262087.1XP_005262144.1  

    See identical proteins and their annotated locations for XP_005262144.1

    UniProtKB/Swiss-Prot
    Q4VCS5
    Conserved Domains (2) summary
    pfam12240
    Location:599808
    Angiomotin_C; Angiomotin C terminal
    cl12013
    Location:457638
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  3. XM_005262088.2XP_005262145.1  

    See identical proteins and their annotated locations for XP_005262145.1

    UniProtKB/Swiss-Prot
    Q4VCS5
    Conserved Domains (2) summary
    pfam12240
    Location:599808
    Angiomotin_C; Angiomotin C terminal
    cl12013
    Location:457638
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  4. XM_005262090.1XP_005262147.1  

    See identical proteins and their annotated locations for XP_005262147.1

    UniProtKB/Swiss-Prot
    Q4VCS5
    Conserved Domains (1) summary
    pfam12240
    Location:190399
    Angiomotin_C; Angiomotin C terminal

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    111929234..111995169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)