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Hras Harvey rat sarcoma virus oncogene [ Mus musculus (house mouse) ]

Gene ID: 15461, updated on 26-Aug-2014
Official Symbol
Hrasprovided by MGI
Official Full Name
Harvey rat sarcoma virus oncogeneprovided by MGI
Primary source
MGI:96224
See related
Ensembl:ENSMUSG00000025499
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ras; H-ras; Hras1; Kras2; Ha-ras; Hras-1; c-H-ras; c-rasHa; c-Ha-ras; Harvey-ras
See Hras in Epigenomics, MapViewer
Location:
7 F5; 7 86.48 cM
Exon count:
6
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 7 NC_000073.6 (141189934..141194107, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene ribonuclease/angiogenin inhibitor 1 Neighboring gene ribosomal protein S9 pseudogene Neighboring gene leucine rich repeat containing 56 Neighboring gene lamin tail domain containing 2 Neighboring gene Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
GTP catabolic process IEA
Inferred from Electronic Annotation
more info
 
Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
Ras protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
cell aging IDA
Inferred from Direct Assay
more info
PubMed 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cell proliferation IPI
Inferred from Physical Interaction
more info
PubMed 
cellular senescence ISO
Inferred from Sequence Orthology
more info
 
endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle checkpoint ISO
Inferred from Sequence Orthology
more info
 
negative regulation of Rho GTPase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Rac GTPase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 
positive regulation of miRNA metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ruffle assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
 
regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
small GTPase mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
intracellular IGI
Inferred from Genetic Interaction
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
Preferred Names
GTPase HRas
Names
GTPase HRas
p21ras
H-Ras-1
H-ras 1 protein
c-Ha-ras transgene
c-Ha-ras p21 protein
transforming protein P21
Harvey rat sarcoma virus oncogene 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130443.1NP_001123915.1  GTPase HRas isoform 1

    See proteins identical to NP_001123915.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR, compared to variant 1, and encodes isoform 1. Isoform 1 is also known as p21. Variants 1 and 3 encode the same protein.
    Source sequence(s)
    BC061885, BU924724, CK788792
    Consensus CDS
    CCDS22003.1
    UniProtKB/Swiss-Prot
    Q61411
    Conserved Domains (2) summary
    cd04138
    Location:3164
    Blast Score: 838
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    COG1100
    Location:16165
    Blast Score: 246
    COG1100; GTPase SAR1 and related small G proteins [General function prediction only]
  2. NM_001130444.1NP_001123916.1  GTPase HRas isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and includes an alternate exon in its 3' coding region, compared to variant 1. The resulting isoform (2) contains a distinct C-terminus and is shorter than isoform 1. Isoform 2 is also known as p21.
    Source sequence(s)
    BC061885, BI731283, BQ963436, CK788792
    Consensus CDS
    CCDS52439.1
    UniProtKB/Swiss-Prot
    Q61411
    Related
    ENSMUSP00000132110, ENSMUST00000168550
    Conserved Domains (2) summary
    cd04138
    Location:3150
    Blast Score: 771
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    COG1100
    Location:16147
    Blast Score: 234
    COG1100; GTPase SAR1 and related small G proteins [General function prediction only]
  3. NM_008284.2NP_032310.2  GTPase HRas isoform 1

    See proteins identical to NP_032310.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform 1. Isoform 1 is also known as p21. Variants 1 and 3 encode the same protein.
    Source sequence(s)
    BC061885, CK788792
    Consensus CDS
    CCDS22003.1
    UniProtKB/Swiss-Prot
    Q61411
    Conserved Domains (2) summary
    cd04138
    Location:3164
    Blast Score: 838
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    COG1100
    Location:16165
    Blast Score: 246
    COG1100; GTPase SAR1 and related small G proteins [General function prediction only]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000073.6 

    Range
    141189934..141194107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006536158.1XP_006536221.1  

    See proteins identical to XP_006536221.1

    Conserved Domains (2) summary
    cd04138
    Location:106267
    Blast Score: 866
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    COG1100
    Location:119268
    Blast Score: 256
    COG1100; GTPase SAR1 and related small G proteins [General function prediction only]
  2. XM_006536159.1XP_006536222.1  

    See proteins identical to XP_006536222.1

    Conserved Domains (2) summary
    cd04138
    Location:106267
    Blast Score: 866
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    COG1100
    Location:119268
    Blast Score: 256
    COG1100; GTPase SAR1 and related small G proteins [General function prediction only]
  3. XM_006536157.1XP_006536220.1  

    See proteins identical to XP_006536220.1

    Conserved Domains (2) summary
    cd04138
    Location:106267
    Blast Score: 866
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    COG1100
    Location:119268
    Blast Score: 256
    COG1100; GTPase SAR1 and related small G proteins [General function prediction only]
  4. XM_006536160.1XP_006536223.1  

    Conserved Domains (2) summary
    cd04138
    Location:106253
    Blast Score: 795
    H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    COG1100
    Location:119250
    Blast Score: 235
    COG1100; GTPase SAR1 and related small G proteins [General function prediction only]

RNA

  1. XR_389950.1 RNA Sequence

  2. XR_389951.1 RNA Sequence

  3. XR_389949.1 RNA Sequence

  4. XR_389952.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000029.1 

    Range
    140983643..140987701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)