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    Hras1 Harvey rat sarcoma virus oncogene 1 [ Mus musculus (house mouse) ]

    Gene ID: 15461, updated on 15-Jun-2013
    Official Symbol
    Hras1provided by MGI
    Official Full Name
    Harvey rat sarcoma virus oncogene 1provided by MGI
    Primary source
    MGI:96224
    See related
    Ensembl:ENSMUSG00000025499
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ras; H-ras; Kras2; Ha-ras; Hras-1; c-H-ras; c-rasHa; c-Ha-ras; Harvey-ras
    Location :
    7 F5; 7 86.48 cM
    Sequence :
    Chromosome: 7; NC_000073.6 (141189934..141194004, complement)
    See Hras1 in Epigenomics, MapViewer

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene ribonuclease/angiogenin inhibitor 1 Neighboring gene ribosomal protein S9 pseudogene Neighboring gene leucine rich repeat containing 56 Neighboring gene RIKEN cDNA 1600016N20 gene Neighboring gene Ras association (RalGDS/AF-6) domain family (N-terminal) member 7

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description
    NP_032310.1 AAU89704.1 Zdhhc18    BIND  PubMed H-Ras interacts with DHHC-18. 
    BioGRID:200416 BioGRID:198143 Apc    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:200416 BioGRID:215356 Brap    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200416 BioGRID:200069 Grin2b    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200416 BioGRID:218148 Kndc1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200416 BioGRID:111831 RAF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:200416 BioGRID:225343 Raf1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Two-hybrid 
    BioGRID:200416 BioGRID:202878 Ralgds    BioGRID  PubMed Two-hybrid 
    BioGRID:200416 BioGRID:207620 Rassf5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200416 BioGRID:214896 Rgl3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200416 BioGRID:230435 Rin1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:200416 BioGRID:204006 Tcf4    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:200416 BioGRID:204403 Ubc    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:200416 BioGRID:239920 Zhx2    BioGRID  PubMed Affinity Capture-Western 

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    GTP catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Ras protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    cell aging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    cell proliferation IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    induction of apoptosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of Rho GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Rac GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
     
    positive regulation of miRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of long-term neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    small GTPase mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    GTPase HRas
    Names
    GTPase HRas
    p21ras
    H-Ras-1
    H-ras 1 protein
    c-Ha-ras transgene
    c-Ha-ras p21 protein
    transforming protein P21

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130443.1NP_001123915.1  GTPase HRas isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR, compared to variant 1, and encodes isoform 1. Isoform 1 is also known as p21. Variants 1 and 3 encode the same protein.
      Source sequence(s)
      BC061885, BU924724, CK788792
      Consensus CDS
      CCDS22003.1
      UniProtKB/TrEMBL
      F7BIB2
      UniProtKB/Swiss-Prot
      Q61411
      Conserved Domains (2) summary
      COG1100
      Location:1165
      Blast Score: 225
      COG1100; GTPase SAR1 and related small G proteins [General function prediction only]
      cd04138
      Location:3164
      Blast Score: 842
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    2. NM_001130444.1NP_001123916.1  GTPase HRas isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and includes an alternate exon in its 3' coding region, compared to variant 1. The resulting isoform (2) contains a distinct C-terminus and is shorter than isoform 1. Isoform 2 is also known as p21.
      Source sequence(s)
      BC061885, BI731283, BQ963436, CK788792
      Consensus CDS
      CCDS52439.1
      UniProtKB/Swiss-Prot
      Q61411
      Related
      ENSMUSP00000132110, ENSMUST00000168550
      Conserved Domains (2) summary
      COG1100
      Location:1147
      Blast Score: 216
      COG1100; GTPase SAR1 and related small G proteins [General function prediction only]
      cd04138
      Location:3150
      Blast Score: 776
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    3. NM_008284.2NP_032310.2  GTPase HRas isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform 1. Isoform 1 is also known as p21. Variants 1 and 3 encode the same protein.
      Source sequence(s)
      BC061885, CK788792
      Consensus CDS
      CCDS22003.1
      UniProtKB/TrEMBL
      F7BIB2
      UniProtKB/Swiss-Prot
      Q61411
      Conserved Domains (2) summary
      COG1100
      Location:1165
      Blast Score: 225
      COG1100; GTPase SAR1 and related small G proteins [General function prediction only]
      cd04138
      Location:3164
      Blast Score: 842
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p1 C57BL/6J

      Range
      141189934..141194004, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000029.1 Alternate Mm_Celera

      Range
      140983643..140987701, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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