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Lipc lipase, hepatic [ Mus musculus (house mouse) ]

Gene ID: 15450, updated on 17-May-2016
Official Symbol
Lipcprovided by MGI
Official Full Name
lipase, hepaticprovided by MGI
Primary source
MGI:MGI:96216
See related
Ensembl:ENSMUSG00000032207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HL; Hpl; AI256194
Orthologs
Location:
9 D; 9 39.57 cM
Exon count:
13
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (70798128..70952221, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (70645935..70782615, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31872 Neighboring gene a disintegrin and metallopeptidase domain 10 Neighboring gene cytochrome c, pseudogene 1 Neighboring gene ribosomal RNA processing 7 homolog A pseudogene Neighboring gene predicted gene, 32017 Neighboring gene predicted gene, 32074 Neighboring gene HCLS1 associated X-1 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
acylglycerol lipase activity ISO
Inferred from Sequence Orthology
more info
 
apolipoprotein binding ISO
Inferred from Sequence Orthology
more info
 
carboxylic ester hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
chylomicron binding ISO
Inferred from Sequence Orthology
more info
 
heparan sulfate proteoglycan binding ISO
Inferred from Sequence Orthology
more info
 
heparin binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
lipid binding ISO
Inferred from Sequence Orthology
more info
 
low-density lipoprotein particle binding ISO
Inferred from Sequence Orthology
more info
 
lysophospholipase activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylcholine 1-acylhydrolase activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity, transferring acyl groups ISO
Inferred from Sequence Orthology
more info
 
triglyceride lipase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cholesterol homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
cholesterol metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
cholesterol transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
chylomicron remnant clearance ISO
Inferred from Sequence Orthology
more info
 
chylomicron remodeling ISO
Inferred from Sequence Orthology
more info
 
fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
glycerophospholipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
heparan sulfate proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
high-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
low-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
 
neutral lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
phosphatidic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
phosphatidylcholine metabolic process ISO
Inferred from Sequence Orthology
more info
 
phosphatidylethanolamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
phosphatidylserine metabolic process ISO
Inferred from Sequence Orthology
more info
 
protein oligomerization ISO
Inferred from Sequence Orthology
more info
 
regulation of plasma lipoprotein particle levels ISO
Inferred from Sequence Orthology
more info
 
triglyceride catabolic process ISO
Inferred from Sequence Orthology
more info
 
triglyceride homeostasis ISO
Inferred from Sequence Orthology
more info
 
triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
 
very-low-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
early endosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
high-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
late endosome ISO
Inferred from Sequence Orthology
more info
 
microvillus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
hepatic triacylglycerol lipase
Names
hepatic lipase
lipase member C
NP_032306.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324472.1NP_001311401.1  hepatic triacylglycerol lipase isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    BC021841, BY337256
  2. NM_001324473.1NP_001311402.1  hepatic triacylglycerol lipase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. Variant 3 is predicted to encode a protein (isoform 2) which lacks the signal peptide that is present in isoform 1.
    Source sequence(s)
    BC021841, BY337256
  3. NM_008280.2NP_032306.2  hepatic triacylglycerol lipase isoform 1 precursor

    See identical proteins and their annotated locations for NP_032306.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    BC021841
    Consensus CDS
    CCDS23324.1
    UniProtKB/Swiss-Prot
    P27656
    Related
    ENSMUSP00000034731, ENSMUST00000034731
    Conserved Domains (3) summary
    TIGR03230
    Location:48492
    lipo_lipase; lipoprotein lipase
    cd00707
    Location:47346
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01758
    Location:353488
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

    Range
    70798128..70952221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242664.1XP_011240966.1  

    UniProtKB/TrEMBL
    Q3TYU0
    Conserved Domains (2) summary
    cd00707
    Location:1261
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01758
    Location:268403
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
  2. XM_006510816.2XP_006510879.1  

    See identical proteins and their annotated locations for XP_006510879.1

    Conserved Domains (3) summary
    TIGR03230
    Location:48508
    lipo_lipase; lipoprotein lipase
    cd00707
    Location:47362
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01758
    Location:369504
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
  3. XM_006510815.2XP_006510878.1  

    See identical proteins and their annotated locations for XP_006510878.1

    Conserved Domains (3) summary
    TIGR03230
    Location:48508
    lipo_lipase; lipoprotein lipase
    cd00707
    Location:47362
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01758
    Location:369504
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
  4. XM_006510817.2XP_006510880.1  

    Conserved Domains (2) summary
    cd00707
    Location:1277
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01758
    Location:284419
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
  5. XM_006510818.2XP_006510881.1  

    Conserved Domains (1) summary
    cd00707
    Location:47362
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

Alternate Mm_Celera

Genomic

  1. AC_000031.1 Alternate Mm_Celera

    Range
    68015071..68150792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)