CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] - Gene

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Summary

Official Symbol: CYP1A2provided by HGNC
Official Full Name: cytochrome P450, family 1, subfamily A, polypeptide 2provided by HGNC
Primary source: HGNC:2596
See related: Ensembl:ENSG00000140505; HPRD:00489; MIM:124060; Vega:OTTHUMG00000172901
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CP12; P3-450; P450(PA)
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 15q24.1

Sequence :: Chromosome: 15; NC_000015.9 (75041184..75048941)

See CYP1A2 in Epigenomics, MapViewer

Chromosome 15 - NC_000015.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Report bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.
Title: Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.
Methanol is the suitable solvent and has no significant effects on CYP1A2-mediated phenacetin O-deethylation.
Title: Effect of dimethyl sulfoxide on in vitro cytochrome P4501A2 mediated phenacetin O-deethylation in human liver microsomes.
The incidence of the 2 CYP1A2 SNPs showed no significant difference between the benign prostatic hyperplasia and the castrated prostate cancer patients.
Title: [Single nucleotide polymorphisms of CYP1A2 and their correlation with prostate cancer].
The CYP1A2 genotype does not appear to be a major susceptibility factor in the development of familial and sporadic porphyria cutanea tarda in the French population.
Title: Comprehensive cytochrome P450 CYP1A2 gene analysis in French caucasian patients with familial and sporadic porphyria cutanea tarda.
Coffee-Parkinson's disease association is strongest among slow metabolizers of caffeine who are homozygous carriers of CYP1A2 polymorphisms.
Title: Coffee, ADORA2A, and CYP1A2: the caffeine connection in Parkinson's disease.
CYP1A2 genotypes interact with environmental risk factors in enhancing the risk to squamous cell lung carcinoma.
Title: Polymorphism in cytochrome P450 1A2 and their interaction with risk factors in determining risk of squamous cell lung carcinoma in men.
Molecular mechanisms of cold-induced CYP1A activation in rat liver microsomes
Title: Molecular mechanisms of cold-induced CYP1A activation in rat liver microsomes.
The findings of our study demonstrate that CYP1A2 phenotype may be an important contributing factor in the development of smoking-related bladder cancer in humans.
Title: Cytochrome P4501A2 phenotype and bladder cancer risk: The Shanghai bladder cancer study.
CYP1A2 was the specific isozyme responsible for the C5-hydroxylation metabolism of liquiritigenin in human liver microsomes.
Title: C5-hydroxylation of liquiritigenin is catalyzed selectively by CYP1A2.
effects of a peripheral mutation on the enzymatic activity
Title: Long-range effects of a peripheral mutation on the enzymatic activity of cytochrome P450 1A2.

Submit: New GeneRIF Correction See all (144)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide association study identifies eight loci associated with blood pressure.

Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.

Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption.

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_000752.1			BIND	PubMed	CYP1A2 interacts with Caffeine.
NP_000752.1			BIND	PubMed	CYP1A2 interacts with Meperidine.
NP_000752.1			BIND	PubMed	CYP1A2 interacts with OXY.
NP_000752.1			BIND	PubMed	CYP1A2 interacts with 17beta-estradiol.
NP_000752.1			BIND	PubMed	CYP1A2 interacts with Phenacetin.
P05177	P16435	POR	HPRD	PubMed
BioGRID:107924	BioGRID:111443	POR	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
aromatase activity	IEA Inferred from Electronic Annotation more info
caffeine oxidase activity	IDA Inferred from Direct Assay more info	PubMed
demethylase activity	IDA Inferred from Direct Assay more info	PubMed
electron carrier activity	TAS Traceable Author Statement more info	PubMed
enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
heme binding	IDA Inferred from Direct Assay more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
oxidoreductase activity	IDA Inferred from Direct Assay more info	PubMed
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
alkaloid metabolic process	IDA Inferred from Direct Assay more info	PubMed
cellular aromatic compound metabolic process	IEA Inferred from Electronic Annotation more info
cellular respiration	IEA Inferred from Electronic Annotation more info
dibenzo-p-dioxin metabolic process	IEA Inferred from Electronic Annotation more info
drug catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
drug metabolic process	IDA Inferred from Direct Assay more info	PubMed
exogenous drug catabolic process	IDA Inferred from Direct Assay more info	PubMed
heterocycle metabolic process	IDA Inferred from Direct Assay more info	PubMed
hydrogen peroxide biosynthetic process	IEA Inferred from Electronic Annotation more info
lung development	IEA Inferred from Electronic Annotation more info
methylation	TAS Traceable Author Statement more info
monocarboxylic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
monoterpenoid metabolic process	IDA Inferred from Direct Assay more info	PubMed
oxidation-reduction process	IDA Inferred from Direct Assay more info	PubMed
oxidative deethylation	IDA Inferred from Direct Assay more info	PubMed
oxidative demethylation	IDA Inferred from Direct Assay more info	PubMed
porphyrin-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
post-embryonic development	IEA Inferred from Electronic Annotation more info
regulation of gene expression	IEA Inferred from Electronic Annotation more info
small molecule metabolic process	TAS Traceable Author Statement more info
steroid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
toxin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
xenobiotic metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum membrane	TAS Traceable Author Statement more info
membrane	IEA Inferred from Electronic Annotation more info
microsome	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: cytochrome P450 1A2

Names: cytochrome P450 1A2; CYPIA2; P450 form 4; cytochrome P450 4; cytochrome P(3)450; cytochrome P450-P3; dioxin-inducible P3-450; microsomal monooxygenase; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2

NP_000752.2

EC 1.14.14.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008431.1 RefSeqGene

Range

31302..39059

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000761.3 → NP_000752.2 cytochrome P450 1A2

Status: REVIEWED

Source sequence(s)

AC091230, BC067424, M55053

Consensus CDS

CCDS32293.1

UniProtKB/Swiss-Prot

P05177

Related

ENSP00000342007, OTTHUMP00000249691, ENST00000343932, OTTHUMT00000421263

Conserved Domains (2) summary

pfam00067
Location:42 – 494
Blast Score: 768

p450; Cytochrome P450

cl12078
Location:14 – 503
Blast Score: 570

CypX; Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000015.9 Reference GRCh37.p5 Primary Assembly

Range

75041184..75048941

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000147.1 Alternate HuRef

Range

51838984..51846743

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC091230.23 (117366..125124)	None
genomic	AF253322.1	AAK25728.1
genomic	CH471136.2	EAW99313.1
genomic	DQ022432.1	AAY26399.1
genomic	L00389.1	AAA35738.1
genomic	M31664.1	AAA52163.1
genomic	M31667.1	AAA52163.1
mRNA	AF182274.1	AAF13599.1
mRNA	BC067424.1	AAH67424.1
mRNA	BC067425.1	AAH67425.1
mRNA	BC067426.1	AAH67426.1
mRNA	BC067427.1	AAH67427.1
mRNA	BC067428.1	AAH67428.1
mRNA	BC067429.1	AAH67429.1
mRNA	M12078.1	AAA52154.1
mRNA	M55053.1	AAA52146.1
mRNA	Z00036.1	CAA77335.1