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CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 [ Homo sapiens (human) ]

Gene ID: 1544, updated on 24-Sep-2014
Official Symbol
CYP1A2provided by HGNC
Official Full Name
cytochrome P450, family 1, subfamily A, polypeptide 2provided by HGNC
Primary source
HGNC:HGNC:2596
See related
Ensembl:ENSG00000140505; HPRD:00489; MIM:124060; Vega:OTTHUMG00000172901
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CP12; P3-450; P450(PA)
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]
See CYP1A2 in Epigenomics, MapViewer
Location:
15q24.1
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 15 NC_000015.10 (74748843..74756600)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75041184..75048941)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene enhancer of mRNA decapping 3 Neighboring gene cytochrome P450, family 1, subfamily A, polypeptide 1 Neighboring gene microRNA 4513 Neighboring gene c-src tyrosine kinase Neighboring gene lectin, mannose-binding, 1 like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.
NHGRI GWA Catalog
Genome-wide association study identifies eight loci associated with blood pressure.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
NHGRI GWA Catalog
Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aromatase activity IEA
Inferred from Electronic Annotation
more info
 
caffeine oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
demethylase activity IDA
Inferred from Direct Assay
more info
PubMed 
electron carrier activity TAS
Traceable Author Statement
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
heme binding IDA
Inferred from Direct Assay
more info
PubMed 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
alkaloid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
arachidonic acid metabolic process TAS
Traceable Author Statement
more info
 
cellular respiration IEA
Inferred from Electronic Annotation
more info
 
cellular response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
dibenzo-p-dioxin metabolic process IEA
Inferred from Electronic Annotation
more info
 
drug catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
drug metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
epoxygenase P450 pathway TAS
Traceable Author Statement
more info
 
exogenous drug catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
heterocycle metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
hydrogen peroxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
methylation TAS
Traceable Author Statement
more info
 
monocarboxylic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
monoterpenoid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
omega-hydroxylase P450 pathway TAS
Traceable Author Statement
more info
 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
oxidative deethylation IDA
Inferred from Direct Assay
more info
PubMed 
oxidative demethylation IDA
Inferred from Direct Assay
more info
PubMed 
porphyrin-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
steroid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
toxin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
cytochrome P450 1A2
Names
cytochrome P450 1A2
CYPIA2
P450 form 4
cytochrome P450 4
cytochrome P(3)450
cytochrome P450-P3
dioxin-inducible P3-450
microsomal monooxygenase
xenobiotic monooxygenase
aryl hydrocarbon hydroxylase
flavoprotein-linked monooxygenase
cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2
NP_000752.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008431.1 

    Range
    31302..39059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000761.4NP_000752.2  cytochrome P450 1A2

    See proteins identical to NP_000752.2

    Status: REVIEWED

    Source sequence(s)
    AC091230, BC067424, KF459683
    Consensus CDS
    CCDS32293.1
    UniProtKB/Swiss-Prot
    P05177
    Related
    ENSP00000342007, OTTHUMP00000249691, ENST00000343932, OTTHUMT00000421263
    Conserved Domains (1) summary
    pfam00067
    Location:42494
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000015.10 

    Range
    74748843..74756600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000147.1 

    Range
    51838984..51846743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 

    Range
    75159686..75167443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)