CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: CYP1A1provided by HGNC
Official Full Name: cytochrome P450, family 1, subfamily A, polypeptide 1provided by HGNC
Primary source: HGNC:2595
See related: Ensembl:ENSG00000140465; HPRD:00148; MIM:108330; Vega:OTTHUMG00000142812
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Summary: This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 15q24.1

Sequence :: Chromosome: 15; NC_000015.9 (75011883..75017877, complement)

See CYP1A1 in Epigenomics, MapViewer

Chromosome 15 - NC_000015.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pelargonidin can bind to and activate the AhR and AhR-dependent gene expression, and induce the CYP1A1 catalytic activity.
Title: Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T.
The combined genotypes of CYP1A1 and GSTs can help to identify vulnerable pregnant women who are subject to high risk of spontaneous preterm delivery due to passive smoking.
Title: Interaction between maternal passive smoking during pregnancy and CYP1A1 and GSTs polymorphisms on spontaneous preterm delivery.
CYP1A1 Ile462Val polymorphism might be a low-penetrant risk factor for acute leukemia
Title: Association between CYP1A1 Ile462Val variation and acute leukemia risk: meta-analyses including 2164 cases and 4160 controls.
Data suggest that maternal obesity down-regulations placental microsomal CYP1A1 activity (but not placental cytosolic CYP1A1 activity). Similar results were obtained for CYP1A1 activity in fetal livers from obese/non-obese Japanese macaques.
Title: Maternal obesity alters feto-placental cytochrome P4501A1 activity.
Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM
Title: Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.
CYP1A1 Ile462Val polymorphism is not associated with endometrial cancer.
Title: Lack of association between the CYP1A1 Ile462Val polymorphism and endometrial cancer risk: a meta-analysis.
CYP1A1 and CYP2E1 gene polymorphisms may increase risk of the oral submucous fibrosis among Eastern Indians.
Title: CYP1AI and CYP2E1 gene polymorphisms may increase susceptibility to Oral Submucous Fibrosis among betel quid chewers of Eastern India.
Human cytochrome P450 (CYP) 1A1 and 1A2 enzymes were found to be responsible for the aristocolochic acid I reductive activation to form AAI-DNA adducts, while its structurally related analogue, CYP1B1 is almost without such activity.
Title: Theoretical investigation of differences in nitroreduction of aristolochic acid I by cytochromes P450 1A1, 1A2 and 1B1.
These data clearly indicate that repressed CYP1 activity in primary human skin fibroblasts is not causally related to AhRR expression, which may serve a different, yet unknown, biological function.
Title: Aryl hydrocarbon receptor repressor (AhRR) function revisited: repression of CYP1 activity in human skin fibroblasts is not related to AhRR expression.
The 2455A>G polymorphism of CYP1A1 results in a significantly increased susceptibility to prostate cancer in all genetic models. [Meta-analysis]
Title: Association of CYP1A1 polymorphisms with prostate cancer risk: an updated meta-analysis.

Submit: New GeneRIF Correction See all (377)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.

Genome-wide association study identifies eight loci associated with blood pressure.

Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.

Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption.

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_000490.1			BIND	PubMed	CYP1A1 interacts with Caffeine.
NP_000490.1			BIND	PubMed	CYP1A1 interacts with Meperidine.
NP_000490.1			BIND	PubMed	CYP1A1 interacts with OXY.
NP_000490.1			BIND	PubMed	CYP1A1 interacts with 17beta-estradiol.
NP_000490.1			BIND	PubMed	CYP1A1 interacts with Phenacetin.
NP_000490.1			BIND	PubMed	CYP1A1 interacts with Progesterone.
P04798	P00167	CYB5A	HPRD	PubMed

Pathways from BioSystems

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AhR pathway, organism-specific biosystem (from WikiPathways)
AhR pathway, organism-specific biosystem
AhR pathway
Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
Benzo(a)pyrene metabolism, organism-specific biosystem (from WikiPathways)
Benzo(a)pyrene metabolism, organism-specific biosystem
Benzo(a)pyrene metabolism
Biological oxidations, organism-specific biosystem (from REACTOME)
Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
Chemical carcinogenesis, organism-specific biosystem (from KEGG)
Chemical carcinogenesis, organism-specific biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
Chemical carcinogenesis, conserved biosystem (from KEGG)
Chemical carcinogenesis, conserved biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
Cytochrome P450 - arranged by substrate type, organism-specific biosystem (from REACTOME)
Cytochrome P450 - arranged by substrate type, organism-specific biosystemThe P450 isozyme system is the major phase 1 biotransforming system in man, accounting for more than 90% of drug biotransformations. This system has huge catalytic versatility and a broad substrate s...
Estrogen metabolism, organism-specific biosystem (from WikiPathways)
Estrogen metabolism, organism-specific biosystem
Estrogen metabolism
Fatty Acid Omega Oxidation, organism-specific biosystem (from WikiPathways)
Fatty Acid Omega Oxidation, organism-specific biosystem
Fatty Acid Omega Oxidation
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
Metabolism of xenobiotics by cytochrome P450, organism-specific biosystem (from KEGG)
Metabolism of xenobiotics by cytochrome P450, organism-specific biosystem
Metabolism of xenobiotics by cytochrome P450
Metabolism of xenobiotics by cytochrome P450, conserved biosystem (from KEGG)
Metabolism of xenobiotics by cytochrome P450, conserved biosystem
Metabolism of xenobiotics by cytochrome P450
Ovarian steroidogenesis, organism-specific biosystem (from KEGG)
Ovarian steroidogenesis, organism-specific biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
Ovarian steroidogenesis, conserved biosystem (from KEGG)
Ovarian steroidogenesis, conserved biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
Oxidative Stress, organism-specific biosystem (from WikiPathways)
Oxidative Stress, organism-specific biosystemOxidative stress represents an imbalance between the production and manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to rep...
PPARA Activates Gene Expression, organism-specific biosystem (from REACTOME)
PPARA Activates Gene Expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
Phase 1 - Functionalization of compounds, organism-specific biosystem (from REACTOME)
Phase 1 - Functionalization of compounds, organism-specific biosystemPhase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conj...
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
Retinol metabolism, organism-specific biosystem (from KEGG)
Retinol metabolism, organism-specific biosystem
Retinol metabolism
Retinol metabolism, conserved biosystem (from KEGG)
Retinol metabolism, conserved biosystem
Retinol metabolism
Steroid hormone biosynthesis, organism-specific biosystem (from KEGG)
Steroid hormone biosynthesis, organism-specific biosystemSteroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 co...
Steroid hormone biosynthesis, conserved biosystem (from KEGG)
Steroid hormone biosynthesis, conserved biosystemSteroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 co...
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE), organism-specific biosystem (from REACTOME)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE), organism-specific biosystemSimilar to the lipoxygenases, cytochrome P450 (CYP) enzymes catalyse the hydroxylation and epoxygenation of arachidonic acid. However, whereas lipoxygenases use an active non-heme iron to abstract h...
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET), organism-specific biosystem (from REACTOME)
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET), organism-specific biosystemThe epoxidation of arachidonic acid by cytochrome P450s (CYPs) results in the formation of unique bioactive lipid mediators termed epoxyeicosatrienoic acids (EETs). Each double bond has been shown t...
Tamoxifen metabolism, organism-specific biosystem (from WikiPathways)
Tamoxifen metabolism, organism-specific biosystem
Tamoxifen metabolism
Tryptophan metabolism, organism-specific biosystem (from KEGG)
Tryptophan metabolism, organism-specific biosystem
Tryptophan metabolism
Tryptophan metabolism, organism-specific biosystem (from WikiPathways)
Tryptophan metabolism, organism-specific biosystem
Tryptophan metabolism
Tryptophan metabolism, conserved biosystem (from KEGG)
Tryptophan metabolism, conserved biosystem
Tryptophan metabolism
Xenobiotics, organism-specific biosystem (from REACTOME)
Xenobiotics, organism-specific biosystemOf the 50 microsomal CYPs, 15 act on xenobiotics. They all possess wide substrate specificity to cater for most foreign compounds that find their way into the body.
cytochrome P450, organism-specific biosystem (from WikiPathways)
cytochrome P450, organism-specific biosystemOxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.
metapathway biotransformation, organism-specific biosystem (from WikiPathways)
metapathway biotransformation, organism-specific biosystem
metapathway biotransformation

General gene information

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Markers

Cyp1a1 (e-PCR), detects polymorphism
- UniSTS:461912

CYP1A1_14 (e-PCR)
- UniSTS:277149

SHGC-6128 (e-PCR)
- UniSTS:42435

STS-K03191 (e-PCR)
- UniSTS:37615

Homology

Homologs of the CYP1A1 gene: The CYP1A1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, A.thaliana, and rice.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
aromatase activity	IEA Inferred from Electronic Annotation more info
demethylase activity	IEA Inferred from Electronic Annotation more info
electron carrier activity	IEA Inferred from Electronic Annotation more info
enzyme binding	IEA Inferred from Electronic Annotation more info
flavonoid 3'-monooxygenase activity	IEA Inferred from Electronic Annotation more info
heme binding	IEA Inferred from Electronic Annotation more info
iron ion binding	IEA Inferred from Electronic Annotation more info
oxidoreductase activity	IDA Inferred from Direct Assay more info	PubMed
oxidoreductase activity, acting on diphenols and related substances as donors	IEA Inferred from Electronic Annotation more info
oxygen binding	TAS Traceable Author Statement more info	PubMed
steroid hydroxylase activity	IEA Inferred from Electronic Annotation more info
vitamin D 24-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
9-cis-retinoic acid biosynthetic process	IEA Inferred from Electronic Annotation more info
aging	IEA Inferred from Electronic Annotation more info
amine metabolic process	IEA Inferred from Electronic Annotation more info
arachidonic acid metabolic process	TAS Traceable Author Statement more info
camera-type eye development	IEA Inferred from Electronic Annotation more info
cell proliferation	IEA Inferred from Electronic Annotation more info
cellular lipid metabolic process	TAS Traceable Author Statement more info
coumarin metabolic process	IEA Inferred from Electronic Annotation more info
dibenzo-p-dioxin catabolic process	IEA Inferred from Electronic Annotation more info
digestive tract development	IEA Inferred from Electronic Annotation more info
drug metabolic process	IDA Inferred from Direct Assay more info	PubMed
embryo development ending in birth or egg hatching	IEA Inferred from Electronic Annotation more info
epoxygenase P450 pathway	TAS Traceable Author Statement more info
flavonoid metabolic process	IEA Inferred from Electronic Annotation more info
hepatocyte differentiation	IEA Inferred from Electronic Annotation more info
hydrogen peroxide biosynthetic process	IEA Inferred from Electronic Annotation more info
insecticide metabolic process	IEA Inferred from Electronic Annotation more info
maternal process involved in parturition	IEA Inferred from Electronic Annotation more info
omega-hydroxylase P450 pathway	TAS Traceable Author Statement more info
oxidation-reduction process	IDA Inferred from Direct Assay more info	PubMed
porphyrin-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
response to antibiotic	IEA Inferred from Electronic Annotation more info
response to arsenic-containing substance	IEA Inferred from Electronic Annotation more info
response to drug	IEA Inferred from Electronic Annotation more info
response to food	IEA Inferred from Electronic Annotation more info
response to herbicide	IEA Inferred from Electronic Annotation more info
response to hyperoxia	IEA Inferred from Electronic Annotation more info
response to hypoxia	IEA Inferred from Electronic Annotation more info
response to iron(III) ion	IEA Inferred from Electronic Annotation more info
response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
response to nematode	IEA Inferred from Electronic Annotation more info
response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
response to virus	IEA Inferred from Electronic Annotation more info
response to vitamin A	IEA Inferred from Electronic Annotation more info
response to wounding	IEA Inferred from Electronic Annotation more info
small molecule metabolic process	TAS Traceable Author Statement more info
vitamin D metabolic process	IC Inferred by Curator more info	PubMed
xenobiotic metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
endoplasmic reticulum membrane	TAS Traceable Author Statement more info
mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 1A1

Names: cytochrome P450 1A1; CYPIA1; cytochrome P450-C; cytochrome P450-P1; cytochrome P450 form 6; xenobiotic monooxygenase; aryl hydrocarbon hydroxylase; flavoprotein-linked monooxygenase; cytochrome P1-450, dioxin-inducible; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1

NP_000490.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008431.1 RefSeqGene

Range

2001..7995, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000499.3 → NP_000490.1 cytochrome P450 1A1

Status: REVIEWED

Source sequence(s)

AC091230

Consensus CDS

CCDS10268.1

UniProtKB/TrEMBL

A0N0X8

UniProtKB/Swiss-Prot

P04798

Related

ENSP00000378488, ENST00000395048

Conserved Domains (2) summary

pfam00067
Location:40 – 493
Blast Score: 886

p450; Cytochrome P450

cl12078
Location:13 – 501
Blast Score: 634

CypX; Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000015.9 Reference GRCh37.p10 Primary Assembly

Range

75011883..75017877, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000147.1 Alternate HuRef

Range

51809772..51815766, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018926.1 Alternate CHM1_1.0

Range

55062819..55068813, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01060499.1 (24236..30230)	None
genomic	AC091230.23 (143431..156425)	None
genomic	AF253322.1	AAK25727.1
genomic	AMYH01006794.1 (194366..200360)	None
genomic	CH471136.2	EAW99314.1
		EAW99315.1
genomic	D10855.1	None
genomic	EF094025.1	ABK41999.1
genomic	X02612.1	CAA26458.1
genomic	X04300.1	CAA27843.1
mRNA	AF040259.1	AAD10199.1
mRNA	AK223108.1	BAD96828.1
mRNA	AK223113.1	BAD96833.1
mRNA	AK310810.1	None
mRNA	AK313880.1	BAG36606.1
mRNA	AM233517.1	CAJ80720.1
mRNA	AM233518.1	CAJ80721.1
mRNA	AM233519.1	CAJ80722.1
mRNA	AM233520.1	CAJ80723.1
mRNA	AM236046.1	CAJ84703.1
mRNA	AM236047.1	CAJ84704.1
mRNA	AY310359.1	AAQ76692.1
mRNA	AY871801.1	AAX62803.1
mRNA	BC023019.1	AAH23019.1
mRNA	K03191.1	AAA52139.1
mRNA	M12079.1	AAA52152.1
other-genetic	DQ891515.2	ABM82441.1
other-genetic	DQ894706.2	ABM85632.1