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CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 [ Homo sapiens (human) ]

Gene ID: 1543, updated on 7-Dec-2014
Official Symbol
CYP1A1provided by HGNC
Official Full Name
cytochrome P450, family 1, subfamily A, polypeptide 1provided by HGNC
Primary source
HGNC:HGNC:2595
See related
Ensembl:ENSG00000140465; HPRD:00148; MIM:108330; Vega:OTTHUMG00000142812
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Summary
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008]
See CYP1A1 in Epigenomics, MapViewer
Location:
15q24.1
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 15 NC_000015.10 (74719542..74725610, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75011883..75017951, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723750 Neighboring gene CDC-like kinase 3 Neighboring gene enhancer of mRNA decapping 3 Neighboring gene cytochrome P450, family 1, subfamily A, polypeptide 2 Neighboring gene microRNA 4513 Neighboring gene c-src tyrosine kinase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
NHGRI GWA Catalog
Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.
NHGRI GWA Catalog
Genome-wide association study identifies eight loci associated with blood pressure.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
NHGRI GWA Catalog
Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aromatase activity IEA
Inferred from Electronic Annotation
more info
 
demethylase activity IEA
Inferred from Electronic Annotation
more info
 
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
flavonoid 3'-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity, acting on diphenols and related substances as donors IEA
Inferred from Electronic Annotation
more info
 
oxygen binding TAS
Traceable Author Statement
more info
PubMed 
steroid hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
vitamin D 24-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
9-cis-retinoic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
amine metabolic process IEA
Inferred from Electronic Annotation
more info
 
arachidonic acid metabolic process TAS
Traceable Author Statement
more info
 
camera-type eye development IEA
Inferred from Electronic Annotation
more info
 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cellular lipid metabolic process TAS
Traceable Author Statement
more info
 
cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
coumarin metabolic process IEA
Inferred from Electronic Annotation
more info
 
demethylation IEA
Inferred from Electronic Annotation
more info
 
dibenzo-p-dioxin catabolic process IEA
Inferred from Electronic Annotation
more info
 
digestive tract development IEA
Inferred from Electronic Annotation
more info
 
drug metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
embryo development ending in birth or egg hatching IEA
Inferred from Electronic Annotation
more info
 
epoxygenase P450 pathway TAS
Traceable Author Statement
more info
 
flavonoid metabolic process IEA
Inferred from Electronic Annotation
more info
 
hepatocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
hydrogen peroxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
insecticide metabolic process IEA
Inferred from Electronic Annotation
more info
 
maternal process involved in parturition IEA
Inferred from Electronic Annotation
more info
 
omega-hydroxylase P450 pathway TAS
Traceable Author Statement
more info
 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
porphyrin-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
response to antibiotic IEA
Inferred from Electronic Annotation
more info
 
response to arsenic-containing substance IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to food IEA
Inferred from Electronic Annotation
more info
 
response to herbicide IEA
Inferred from Electronic Annotation
more info
 
response to hyperoxia IEA
Inferred from Electronic Annotation
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to immobilization stress IEA
Inferred from Electronic Annotation
more info
 
response to iron(III) ion IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to nematode IEA
Inferred from Electronic Annotation
more info
 
response to virus IEA
Inferred from Electronic Annotation
more info
 
response to vitamin A IEA
Inferred from Electronic Annotation
more info
 
response to wounding IEA
Inferred from Electronic Annotation
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
vitamin D metabolic process IC
Inferred by Curator
more info
PubMed 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cytochrome P450 1A1
Names
cytochrome P450 1A1
CYPIA1
cytochrome P450-C
cytochrome P450-P1
cytochrome P450 form 6
xenobiotic monooxygenase
aryl hydrocarbon hydroxylase
flavoprotein-linked monooxygenase
cytochrome P1-450, dioxin-inducible
cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1
NP_000490.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008431.1 

    Range
    2001..7995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000499.3NP_000490.1  cytochrome P450 1A1

    See proteins identical to NP_000490.1

    Status: REVIEWED

    Source sequence(s)
    AC091230
    Consensus CDS
    CCDS10268.1
    UniProtKB/TrEMBL
    A0N0X8
    UniProtKB/Swiss-Prot
    P04798
    Related
    ENSP00000378488, ENST00000395048
    Conserved Domains (1) summary
    pfam00067
    Location:40493
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000015.10 

    Range
    74719542..74725610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254185.1XP_005254242.1  

    See proteins identical to XP_005254242.1

    UniProtKB/TrEMBL
    A0N0X8
    UniProtKB/Swiss-Prot
    P04798
    Related
    ENSP00000369050, OTTHUMP00000183469, ENST00000379727, OTTHUMT00000286396
    Conserved Domains (1) summary
    pfam00067
    Location:40493
    p450; Cytochrome P450

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 

    Range
    75130208..75136202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000147.1 

    Range
    51809772..51815766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)