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SLC2A12 solute carrier family 2 member 12 [ Homo sapiens (human) ]

Gene ID: 154091, updated on 26-May-2016
Official Symbol
SLC2A12provided by HGNC
Official Full Name
solute carrier family 2 member 12provided by HGNC
Primary source
HGNC:HGNC:18067
See related
Ensembl:ENSG00000146411 HPRD:11572; MIM:610372
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUT8; GLUT12
Summary
SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]
Orthologs
Location:
6q23.2
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (133987581..134052668, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (134308719..134373789, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene transcription factor 21 Neighboring gene TATA-box binding protein like 1 Neighboring gene epithelial splicing regulatory protein 1 pseudogene Neighboring gene high mobility group AT-hook 1 pseudogene 7 Neighboring gene serum/glucocorticoid regulated kinase 1 Neighboring gene RNA, 5S ribosomal pseudogene 218

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
D-glucose transmembrane transporter activity TAS
Traceable Author Statement
more info
 
glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
sugar:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
glucose import IBA
Inferred from Biological aspect of Ancestor
more info
 
glucose transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
proton transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endomembrane system IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
solute carrier family 2, facilitated glucose transporter member 12
Names
GLUT-12
glucose transporter type 12
solute carrier family 2 (facilitated glucose transporter), member 12

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145176.2NP_660159.1  solute carrier family 2, facilitated glucose transporter member 12

    See identical proteins and their annotated locations for NP_660159.1

    Status: VALIDATED

    Source sequence(s)
    AL035699, AL833602, AY046419, DB253903
    Consensus CDS
    CCDS5169.1
    UniProtKB/Swiss-Prot
    Q8TD20
    Related
    ENSP00000275230, OTTHUMP00000017245, ENST00000275230, OTTHUMT00000042302
    Conserved Domains (2) summary
    cd06174
    Location:45549
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:45564
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    133987581..134052668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715349.2XP_006715412.1  

    Conserved Domains (2) summary
    cd06174
    Location:45363
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    COG0477
    Location:43371
    ProP; MFS family permease [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    134570960..134635958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)