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CNKSR3 CNKSR family member 3 [ Homo sapiens (human) ]

Gene ID: 154043, updated on 26-May-2016
Official Symbol
CNKSR3provided by HGNC
Official Full Name
CNKSR family member 3provided by HGNC
Primary source
HGNC:HGNC:23034
See related
Ensembl:ENSG00000153721 HPRD:14349
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAGI1
Orthologs
Location:
6q25.2
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (154405299..154510619, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (154726433..154831753, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene opioid receptor mu 1 Neighboring gene interaction protein for cytohesin exchange factors 1 Neighboring gene ribosomal protein L17 pseudogene 24 Neighboring gene uncharacterized LOC105378067 Neighboring gene atherin-like Neighboring gene chromosome 6 open reading frame 203 pseudogene Neighboring gene ribosomal protein S4X pseudogene 8

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
NHGRI GWA Catalog
Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ31349

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
connector enhancer of kinase suppressor of ras 3
Names
CNK homolog protein 3
CNK3
connector enhancer of KSR 3
maguin-like protein
membrane associated guanylate kinase interacting protein-like 1
membrane associated guanylate kinase, WW and PDZ domain containing 1
membrane-associated guanylate kinase-interacting protein-like 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173515.2NP_775786.2  connector enhancer of kinase suppressor of ras 3

    See identical proteins and their annotated locations for NP_775786.2

    Status: VALIDATED

    Source sequence(s)
    AK055911, AY328892, AY328893, BC060761
    Consensus CDS
    CCDS5246.1
    UniProtKB/Swiss-Prot
    Q6P9H4
    Related
    ENSP00000475915, OTTHUMP00000017466, ENST00000607772, OTTHUMT00000042792
    Conserved Domains (5) summary
    pfam10534
    Location:80174
    CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
    cd09511
    Location:472
    SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
    smart00454
    Location:469
    SAM; Sterile alpha motif
    pfam06663
    Location:330495
    DUF1170; Protein of unknown function (DUF1170)
    cl00117
    Location:221305
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    154405299..154510619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535485.1XP_011533787.1  

    Related
    ENSP00000418975, OTTHUMP00000212054, ENST00000479339, OTTHUMT00000348631
    Conserved Domains (5) summary
    pfam10534
    Location:70164
    CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
    cd09511
    Location:862
    SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
    smart00454
    Location:1359
    SAM; Sterile alpha motif
    pfam06663
    Location:320485
    DUF1170; Protein of unknown function (DUF1170)
    cl00117
    Location:211295
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    154989508..155094800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)