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Hnrnpk heterogeneous nuclear ribonucleoprotein K [ Mus musculus (house mouse) ]

Gene ID: 15387, updated on 8-May-2016
Official Symbol
Hnrnpkprovided by MGI
Official Full Name
heterogeneous nuclear ribonucleoprotein Kprovided by MGI
Primary source
MGI:MGI:99894
See related
Ensembl:ENSMUSG00000021546 Vega:OTTMUSG00000035894
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KBBP; NOVA; Hnrpk
Summary
The protein encoded by this gene is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex, and is a poly-cytosine binding protein (PCBP). It is found in multiple subcellular compartments including the nucleus, cytoplasm and mitochondria. This gene product is thought to interact with RNA, DNA, and protein, and is involved in multiple cellular processes, including transcription, chromatin remodeling, DNA damage response, signal transduction, mRNA splicing, export, and translation. Multiple transcript variants and protein isoforms exist, with some isoforms containing a unique C-terminus. There are four pseudogenes of this gene, found on chromosomes 2, 3, 7 and 13. [provided by RefSeq, Aug 2014]
Orthologs
Location:
13; 13 B1
Exon count:
20
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (58391132..58403343, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (58493312..58503877, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene kinesin family member 27 Neighboring gene microRNA 6369 Neighboring gene RIKEN cDNA 2210016F16 gene Neighboring gene microRNA 7-1 Neighboring gene RecQ mediated genome instability 1 Neighboring gene predicted gene, 33875 Neighboring gene predicted gene, 33820 Neighboring gene predicted gene, 40966

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC102032

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATPase binding ISO
Inferred from Sequence Orthology
more info
 
C-rich single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
actinin binding ISO
Inferred from Sequence Orthology
more info
 
core promoter proximal region DNA binding ISO
Inferred from Sequence Orthology
more info
 
double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
lamin binding ISO
Inferred from Sequence Orthology
more info
 
mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
mRNA CDS binding ISO
Inferred from Sequence Orthology
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
pre-mRNA 3'-splice site binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
 
single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
RNA processing IEA
Inferred from Electronic Annotation
more info
 
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
cellular response to forskolin ISO
Inferred from Sequence Orthology
more info
 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
cerebral cortex development ISO
Inferred from Sequence Orthology
more info
 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of branching morphogenesis of a nerve ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of low-density lipoprotein particle receptor biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synapse maturation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon terminus ISO
Inferred from Sequence Orthology
more info
 
catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
cell cortex ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
intracellular ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
heterogeneous nuclear ribonucleoprotein K

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301340.1NP_001288269.1  heterogeneous nuclear ribonucleoprotein K isoform 1

    See identical proteins and their annotated locations for NP_001288269.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AK011428, AK160615, AV367088, BC089328, BE993983
    Consensus CDS
    CCDS79199.1
    UniProtKB/Swiss-Prot
    P61979
    UniProtKB/TrEMBL
    Q5FWJ5
    Conserved Domains (3) summary
    pfam08067
    Location:143
    ROKNT; ROKNT (NUC014) domain
    cd00105
    Location:389452
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:146210
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
  2. NM_001301341.1NP_001288270.1  heterogeneous nuclear ribonucleoprotein K isoform 1

    See identical proteins and their annotated locations for NP_001288270.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AK078777, AV367088, BC089328, BE993983
    Consensus CDS
    CCDS79199.1
    UniProtKB/Swiss-Prot
    P61979
    UniProtKB/TrEMBL
    Q5FWJ5
    Related
    ENSMUSP00000112104, OTTMUSP00000050778, ENSMUST00000116403, OTTMUST00000092042
    Conserved Domains (3) summary
    pfam08067
    Location:143
    ROKNT; ROKNT (NUC014) domain
    cd00105
    Location:389452
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:146210
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
  3. NM_001301343.1NP_001288272.1  heterogeneous nuclear ribonucleoprotein K isoform 1

    See identical proteins and their annotated locations for NP_001288272.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AK166927, AV367088, BC089328, BE993983, BY794631
    Consensus CDS
    CCDS79199.1
    UniProtKB/Swiss-Prot
    P61979
    UniProtKB/TrEMBL
    Q5FWJ5
    Conserved Domains (3) summary
    pfam08067
    Location:143
    ROKNT; ROKNT (NUC014) domain
    cd00105
    Location:389452
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:146210
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
  4. NM_001301344.1NP_001288273.1  heterogeneous nuclear ribonucleoprotein K isoform 3

    See identical proteins and their annotated locations for NP_001288273.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon compared to variant 1. It encodes isoform 3 which is shorter than isoform 1.
    Source sequence(s)
    AK011428, AK051313, AK151689, AK160615, AV367088, BC089328, BE993983
    Consensus CDS
    CCDS79198.1
    UniProtKB/Swiss-Prot
    P61979
    UniProtKB/TrEMBL
    B2M1R6, Q3U9Q3, Q5FWJ5
    Related
    ENSMUSP00000135647, OTTMUSP00000061593, ENSMUST00000177019, OTTMUST00000110426
    Conserved Domains (3) summary
    pfam08067
    Location:143
    ROKNT; ROKNT (NUC014) domain
    cd00105
    Location:365428
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:122186
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
  5. NM_001301345.1NP_001288274.1  heterogeneous nuclear ribonucleoprotein K isoform 4

    See identical proteins and their annotated locations for NP_001288274.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an in-frame exon and uses an alternative splice site in the 3' terminal exon, which results in a frameshift, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK011428, AK051313, AV367088, BC089328, BE993983
    Consensus CDS
    CCDS79197.1
    UniProtKB/Swiss-Prot
    P61979
    UniProtKB/TrEMBL
    Q5FWJ5
    Related
    ENSMUSP00000135354, OTTMUSP00000061594, ENSMUST00000176207, OTTMUST00000110427
    Conserved Domains (3) summary
    pfam08067
    Location:143
    ROKNT; ROKNT (NUC014) domain
    cd00105
    Location:365428
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:122186
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
  6. NM_025279.3NP_079555.1  heterogeneous nuclear ribonucleoprotein K isoform 2

    See identical proteins and their annotated locations for NP_079555.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternative splice site in the 3' terminal exon, which results in a frameshift, compared to variant 1. It encodes isoform 2 which has a distinct and shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AK011428, AV367088, BC089328, BE993983
    Consensus CDS
    CCDS49283.1
    UniProtKB/Swiss-Prot
    P61979
    UniProtKB/TrEMBL
    Q5FWJ5
    Related
    ENSMUSP00000039269, OTTMUSP00000050779, ENSMUST00000043269, OTTMUST00000092043
    Conserved Domains (3) summary
    pfam08067
    Location:143
    ROKNT; ROKNT (NUC014) domain
    cd00105
    Location:389452
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:146210
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

    Range
    58391132..58403343 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517106.2XP_006517169.1  

    See identical proteins and their annotated locations for XP_006517169.1

    UniProtKB/TrEMBL
    B2M1R6
    Conserved Domains (3) summary
    pfam08067
    Location:143
    ROKNT; ROKNT (NUC014) domain
    cd00105
    Location:365428
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:122186
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
  2. XM_006517104.1XP_006517167.1  

    See identical proteins and their annotated locations for XP_006517167.1

    UniProtKB/Swiss-Prot
    P61979
    UniProtKB/TrEMBL
    Q5FWJ5
    Conserved Domains (3) summary
    pfam08067
    Location:143
    ROKNT; ROKNT (NUC014) domain
    cd00105
    Location:389452
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:146210
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
  3. XM_006517103.2XP_006517166.1  

    See identical proteins and their annotated locations for XP_006517166.1

    UniProtKB/Swiss-Prot
    P61979
    UniProtKB/TrEMBL
    Q5FWJ5
    Conserved Domains (3) summary
    pfam08067
    Location:143
    ROKNT; ROKNT (NUC014) domain
    cd00105
    Location:389452
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:146210
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

Alternate Mm_Celera

Genomic

  1. AC_000035.1 Alternate Mm_Celera

    Range
    59453495..59465706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)