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Hnrnpab heterogeneous nuclear ribonucleoprotein A/B [ Mus musculus (house mouse) ]

Gene ID: 15384, updated on 28-May-2016
Official Symbol
Hnrnpabprovided by MGI
Official Full Name
heterogeneous nuclear ribonucleoprotein A/Bprovided by MGI
Primary source
MGI:MGI:1330294
See related
Ensembl:ENSMUSG00000020358 Vega:OTTMUSG00000005602
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CBF-A; Cgbfa; Hnrpab; 3010025C11Rik
Summary
This gene encodes a protein with consensus RNA binding domains present in a number of other RNA binding proteins and a glycine-rich C-terminus. This gene overlaps in a tail-to-tail orientation the gene encoding alanine-glyoxylate aminotransferase 2-like 2. Some of the exons of this gene are interspersed with exons of alanine-glyoxylate aminotransferase 2-like 2. Two alternatively spliced transcript variants that encode distinct proteins have been described for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
11; 11 B1.3
Exon count:
8
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (51600100..51606881, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (51413602..51420383, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC049762 Neighboring gene CDC like kinase 4 Neighboring gene collagen, type XXIII, alpha 1 Neighboring gene 5-phosphohydroxy-L-lysine phospholyase Neighboring gene RIKEN cDNA D930048N14 gene Neighboring gene required for meiotic nuclear division 5 homolog B Neighboring gene NHP2 ribonucleoprotein Neighboring gene NEDD4 binding protein 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • mRNA processing, organism-specific biosystem (from WikiPathways)
    mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
intracellular ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
heterogeneous nuclear ribonucleoprotein A/B
Names
CArG-binding factor-A
S1 protein D2
hnRNP A/B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048061.1NP_001041526.1  heterogeneous nuclear ribonucleoprotein A/B isoform 1

    See identical proteins and their annotated locations for NP_001041526.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AL645602, BQ445737, CA325334, CF751043, CJ166869
    Consensus CDS
    CCDS48787.1
    UniProtKB/TrEMBL
    Q20BD0
    Related
    ENSMUSP00000104731, OTTMUSP00000005764, ENSMUST00000109103, OTTMUST00000012465
    Conserved Domains (4) summary
    smart00360
    Location:76146
    RRM; RNA recognition motif
    cd12584
    Location:155234
    RRM2_hnRNPAB; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
    cd12757
    Location:76150
    RRM1_hnRNPAB; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
    pfam08143
    Location:176
    CBFNT; CBFNT (NUC161) domain
  2. NM_010448.3NP_034578.1  heterogeneous nuclear ribonucleoprotein A/B isoform 2

    See identical proteins and their annotated locations for NP_034578.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AK013384, CJ166869
    Consensus CDS
    CCDS24654.1
    UniProtKB/Swiss-Prot
    Q99020
    UniProtKB/TrEMBL
    Q544Z3
    Related
    ENSMUSP00000074238, OTTMUSP00000005762, ENSMUST00000074669, OTTMUST00000012463
    Conserved Domains (4) summary
    smart00360
    Location:76146
    RRM; RNA recognition motif
    cd12757
    Location:76150
    RRM1_hnRNPAB; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) and similar proteins
    pfam08143
    Location:176
    CBFNT; CBFNT (NUC161) domain
    cl17169
    Location:155234
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    51600100..51606881 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    56171430..56178210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)