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    RNF145 ring finger protein 145 [ Homo sapiens ]

    Gene ID: 153830, updated on 11-May-2012
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    Summary

    Official Symbol
    RNF145provided by HGNC
    Official Full Name
    ring finger protein 145provided by HGNC
    Primary source
    HGNC:20853
    See related
    Ensembl:ENSG00000145860; HPRD:08113; Vega:OTTHUMG00000130306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLJ31951; FLJ44310; DKFZp686M11215
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    Genomic context

    Location :
    5q33.3
    Sequence :
    Chromosome: 5; NC_000005.9 (158584417..158637061, complement)
    See RNF145 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene uracil-DNA glycosylase pseudogene Neighboring gene early B-cell factor 1 Neighboring gene ubiquitin-like domain containing CTD phosphatase 1 Neighboring gene interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Soranzo N, et al. Nat Genet, 2009 Nov. PMID 19820697.
    4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. Otsuki T, et al. DNA Res, 2005. PMID 16303743.
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:127521 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    RING finger protein 145
    Names
    RING finger protein 145
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199380.1 → NP_001186309.1  RING finger protein 145 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK308394, AL831829, BC042684
      Consensus CDS
      CCDS56393.1
      UniProtKB/TrEMBL
      E7EVI7
      UniProtKB/TrEMBL
      Q8NDT8
      UniProtKB/Swiss-Prot
      Q96MT1
      Related
      ENSP00000430955, OTTHUMP00000224219, ENST00000518802, OTTHUMT00000374049
      Conserved Domains (3) summary
      cd00162
      Location:567 – 608
      Blast Score: 125
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam13705
      Location:37 – 536
      Blast Score: 1414
      TRC8_N; TRC8 N-terminal domain
      pfam13923
      Location:564 – 605
      Blast Score: 127
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    2. NM_001199381.1 → NP_001186310.1  RING finger protein 145 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 5' exon, as compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK304435, AL697229, AL831829
      Consensus CDS
      CCDS56392.1
      UniProtKB/TrEMBL
      Q8NDT8
      Related
      ENSP00000445115, ENST00000413445
      Conserved Domains (3) summary
      cd00162
      Location:554 – 595
      Blast Score: 125
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam13705
      Location:24 – 523
      Blast Score: 1409
      TRC8_N; TRC8 N-terminal domain
      pfam13923
      Location:551 – 592
      Blast Score: 126
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    3. NM_001199382.1 → NP_001186311.1  RING finger protein 145 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate 5' exon, as compared to variant 1. The resulting isoform (4) lacks a segment in the N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK304228, AL831829, BC042684, DC418555
      Consensus CDS
      CCDS56391.1
      UniProtKB/TrEMBL
      Q8NDT8
      UniProtKB/Swiss-Prot
      Q96MT1
      Related
      ENSP00000429071, OTTHUMP00000224220, ENST00000520638, OTTHUMT00000374050
      Conserved Domains (3) summary
      cd00162
      Location:551 – 592
      Blast Score: 124
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam13705
      Location:21 – 520
      Blast Score: 1407
      TRC8_N; TRC8 N-terminal domain
      pfam13923
      Location:548 – 589
      Blast Score: 126
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    4. NM_001199383.1 → NP_001186312.1  RING finger protein 145 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate 5' exon, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (5) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK292854, AL831829, CK821118
      Consensus CDS
      CCDS56390.1
      UniProtKB/TrEMBL
      A8K9Y9
      UniProtKB/TrEMBL
      Q8NDT8
      UniProtKB/Swiss-Prot
      Q96MT1
      Related
      ENSP00000409064, OTTHUMP00000224218, ENST00000424310, OTTHUMT00000374048
      Conserved Domains (3) summary
      cd00162
      Location:537 – 578
      Blast Score: 124
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam13705
      Location:7 – 506
      Blast Score: 1407
      TRC8_N; TRC8 N-terminal domain
      pfam13923
      Location:534 – 575
      Blast Score: 126
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    5. NM_144726.2 → NP_653327.1  RING finger protein 145 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK056513, AL831829, BC042684
      Consensus CDS
      CCDS4344.1
      UniProtKB/TrEMBL
      Q8NDT8
      UniProtKB/Swiss-Prot
      Q96MT1
      Related
      ENSP00000274542, OTTHUMP00000160819, ENST00000274542, OTTHUMT00000252651
      Conserved Domains (3) summary
      cd00162
      Location:565 – 606
      Blast Score: 123
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam13705
      Location:35 – 534
      Blast Score: 1414
      TRC8_N; TRC8 N-terminal domain
      pfam13923
      Location:562 – 603
      Blast Score: 125
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      158584417..158637061, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      153679240..153731516, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC134043.1 (24613..75028) None
    genomic CH471062.2 EAW61579.1
    mRNA AK056513.1 BAB71200.1
    mRNA AK075101.1 BAC11401.1
    mRNA AK098802.1 BAC05416.1
    mRNA AK126290.1 BAG54304.1
    mRNA AK292854.1 BAF85543.1
    mRNA AK294323.1 BAH11735.1
    mRNA AK304228.1 BAH14139.1
    mRNA AK304435.1 BAH14185.1
    mRNA AK308394.1 None
    mRNA AK311433.1 None
    mRNA AL697229.1 None
    mRNA AL831829.1 CAD38542.1
    mRNA BC042684.1 AAH42684.1
    mRNA BC044767.1 None
    mRNA BX537635.1 CAD97802.1
    mRNA BX640806.1 CAE45888.1
    mRNA CK821118.1 None
    mRNA DC418555.1 None
    other-genetic JF432381.1 ADZ15598.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6MZY8 GenPept UniProtKB/TrEMBL:Q6MZY8
    Q7Z3N5 GenPept UniProtKB/TrEMBL:Q7Z3N5
    Q8N783 GenPept UniProtKB/TrEMBL:Q8N783
    Q8NC08 GenPept UniProtKB/TrEMBL:Q8NC08
    Q8NDT8 GenPept UniProtKB/TrEMBL:Q8NDT8
    Q96MT1.2 GenPept UniProtKB/Swiss-Prot:Q96MT1
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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