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CYC1 cytochrome c-1 [ Homo sapiens (human) ]

Gene ID: 1537, updated on 7-Dec-2014
Official Symbol
CYC1provided by HGNC
Official Full Name
cytochrome c-1provided by HGNC
Primary source
HGNC:HGNC:2579
See related
Ensembl:ENSG00000179091; HPRD:00480; MIM:123980; Vega:OTTHUMG00000165242
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UQCR4; MC3DN6
Summary
This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013]
See CYC1 in Epigenomics, MapViewer
Location:
8q24.3
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 8 NC_000008.11 (144095035..144097527)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145149960..145152428)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene exosome component 4 Neighboring gene microRNA 6847 Neighboring gene glycosylphosphatidylinositol anchor attachment 1 Neighboring gene SHANK-associated RH domain interactor Neighboring gene MAF1 homolog (S. cerevisiae)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of cytochrome c-1 (CYC1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
vpr HIV-1 Vpr-induced mitochondrial membrane permeabilization and caspase activation results in release of cytochrome c PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity TAS
Traceable Author Statement
more info
PubMed 
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular metabolic process TAS
Traceable Author Statement
more info
 
respiratory electron transport chain TAS
Traceable Author Statement
more info
 
response to glucagon IEA
Inferred from Electronic Annotation
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
respiratory chain IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
cytochrome c1, heme protein, mitochondrial
Names
cytochrome c1, heme protein, mitochondrial
complex III subunit 4
complex III subunit IV
cytochrome b-c1 complex subunit 4
ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033872.1 

    Range
    5001..7493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001916.4NP_001907.2  cytochrome c1, heme protein, mitochondrial precursor

    See proteins identical to NP_001907.2

    Status: REVIEWED

    Source sequence(s)
    AK026633, AK225796, BG328536, BQ574597, CN369438
    Consensus CDS
    CCDS6415.1
    UniProtKB/Swiss-Prot
    P08574
    Related
    ENSP00000317159, OTTHUMP00000229040, ENST00000318911, OTTHUMT00000382895
    Conserved Domains (2) summary
    COG2857
    Location:84287
    CYT1; Cytochrome c1 [Energy production and conversion]
    pfam02167
    Location:96287
    Cytochrom_C1; Cytochrome C1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000008.11 

    Range
    144095035..144097527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 

    Range
    145190173..145192638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000140.1 

    Range
    140425842..140428307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)