Hmox1 heme oxygenase (decycling) 1 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Hmox1provided by MGI
Official Full Name: heme oxygenase (decycling) 1provided by MGI
Primary source: MGI:96163
See related: Ensembl:ENSMUSG00000005413; Vega:OTTMUSG00000030644
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HO1; HO-1; Hmox; Hemox; Hsp32; D8Wsu38e

Genomic context

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Location :: 8 C1; 8 35.59 cM

Sequence :: Chromosome: 8; NC_000074.6 (75093618..75100593)

See Hmox1 in Epigenomics, MapViewer

Chromosome 8 - NC_000074.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

High HO-1 expression may also inhibit oxidative stress and delay the process of intervertebral disc degeneration.
Title: Heme oxygenase-1 modulates degeneration of the intervertebral disc after puncture in Bach 1 deficient mice.
Myeloid heme oxygenase-1 haploinsufficiency reduces high fat diet-induced insulin resistance by affecting adipose macrophage infiltration.
Title: Myeloid heme oxygenase-1 haploinsufficiency reduces high fat diet-induced insulin resistance by affecting adipose macrophage infiltration in mice.
Reactive oxygen species-dependent HO-1 protein expression by PGs, which inhibited LPS-, LTA-, and PGN-induced iNOS/NO production, was identified in macrophages.
Title: Prostaglandins as negative regulators against lipopolysaccharide, lipoteichoic acid, and peptidoglycan-induced inducible nitric oxide synthase/nitric oxide production through reactive oxygen species-dependent heme oxygenase 1 expression in macrophages.
MsrA overexpression in MsrA-depleted cells led to the reduction of increased HO-1 expression, and suppressed nuclear accumulation of Nrf2.
Title: Methionine sulfoxide reductase A attenuates heme oxygenase-1 induction through inhibition of Nrf2 activation.
Iron/heme-mediated toxicity is responsible for renal injury in the kidneys of Hmox1-deficient mice.
Title: Ferroportin expression in haem oxygenase 1-deficient mice.
Remote delivery of DNA encoding for Hmox1 was cardioprotective, as evidenced by preserved cardiac structure and function. Angiogenesis was not induced by Hmox1 treatment.
Title: Protecting the heart through delivering DNA encoding for heme oxygenase-1 into skeletal muscle.
protective role in the control of Mycobacterium avium infection
Title: Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteria.
Adipocyte-specific overexpression of HO-1 attenuates HF-mediated adiposity and vascular dysfunction.
Title: Heme oxygenase gene targeting to adipocytes attenuates adiposity and vascular dysfunction in mice fed a high-fat diet.
Endothelium-specific AMPK activation is sufficient to protect against diabetes mellitus-induced aggravation of vascular injury by promoting endothelial function and reendothelialization via upregulation of heme oxygenase-1 and SDF-1alpha.
Title: Endothelium-selective activation of AMP-activated protein kinase prevents diabetes mellitus-induced impairment in vascular function and reendothelialization via induction of heme oxygenase-1 in mice.
Review of the role that HO-1 plays in placental vasculature development and how HO-1 deficiency may contribute to pregnancy complications, such as fetal growth restriction, pre-eclampsia, spontaneous abortions and premature births.
Title: A deficiency in haem oxygenase-1 induces foetal growth restriction by placental vasculature defects.

Submit: New GeneRIF Correction See all (272)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (4) 1 citation

Pathways from BioSystems

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HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
Heme degradation, organism-specific biosystem (from REACTOME)
Heme degradation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Iron uptake and transport, organism-specific biosystem (from REACTOME)
Iron uptake and transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Keap1-Nrf2, organism-specific biosystem (from WikiPathways)
Keap1-Nrf2, organism-specific biosystemBased on [http://www.nature.com/nrc/journal/v3/n10/fig_tab/nrc1189_F4.html Surh, 2003, figure 4].
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of porphyrins, organism-specific biosystem (from REACTOME)
Metabolism of porphyrins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Mineral absorption, organism-specific biosystem (from KEGG)
Mineral absorption, organism-specific biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
Mineral absorption, conserved biosystem (from KEGG)
Mineral absorption, conserved biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
Oxidative Stress, organism-specific biosystem (from WikiPathways)
Oxidative Stress, organism-specific biosystem
Oxidative Stress
Porphyrin and chlorophyll metabolism, organism-specific biosystem (from KEGG)
Porphyrin and chlorophyll metabolism, organism-specific biosystem
Porphyrin and chlorophyll metabolism
Porphyrin and chlorophyll metabolism, conserved biosystem (from KEGG)
Porphyrin and chlorophyll metabolism, conserved biosystem
Porphyrin and chlorophyll metabolism
Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
Transmembrane transport of small molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)
heme degradation, organism-specific biosystem (from BIOCYC)
heme degradation, organism-specific biosystem
heme degradation

General gene information

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Markers

d19arb1 (e-PCR)
- UniSTS:121355

PMC341742P5 (e-PCR)
- UniSTS:273179

PMC341742P6 (e-PCR)
- UniSTS:273180

PMC341742P7 (e-PCR)
- UniSTS:273181

UniSTS:472912 (e-PCR)
- UniSTS:472912

Hmox1 (e-PCR), detects polymorphism
- UniSTS:472912

RH126510 (e-PCR)
- UniSTS:142732

PMC164851P2 (e-PCR)
- UniSTS:271522

PMC129038P1 (e-PCR)
- UniSTS:270578

Homology

Homologs of the Hmox1 gene: The Hmox1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enzyme binding	ISO Inferred from Sequence Orthology more info
heme binding	ISO Inferred from Sequence Orthology more info
heme oxygenase (decyclizing) activity	ISO Inferred from Sequence Orthology more info
metal ion binding	IEA Inferred from Electronic Annotation more info
oxidoreductase activity	ISO Inferred from Sequence Orthology more info
phospholipase D activity	ISO Inferred from Sequence Orthology more info
protein homodimerization activity	ISO Inferred from Sequence Orthology more info
signal transducer activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
angiogenesis	ISO Inferred from Sequence Orthology more info
cell death	ISO Inferred from Sequence Orthology more info
cellular response to cadmium ion	IDA Inferred from Direct Assay more info	PubMed
erythrocyte homeostasis	ISO Inferred from Sequence Orthology more info
heme catabolic process	ISO Inferred from Sequence Orthology more info
heme metabolic process	IDA Inferred from Direct Assay more info	PubMed
heme oxidation	ISO Inferred from Sequence Orthology more info
intracellular signal transduction	ISO Inferred from Sequence Orthology more info
intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
iron ion homeostasis	ISO Inferred from Sequence Orthology more info
negative regulation of DNA binding	ISO Inferred from Sequence Orthology more info
negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of mast cell cytokine production	ISO Inferred from Sequence Orthology more info
negative regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
negative regulation of muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
negative regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
oxidation-reduction process	IEA Inferred from Electronic Annotation more info
positive regulation of I-kappaB kinase/NF-kappaB cascade	ISO Inferred from Sequence Orthology more info
positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
protein homooligomerization	ISO Inferred from Sequence Orthology more info
regulation of blood pressure	ISO Inferred from Sequence Orthology more info
regulation of sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
regulation of transcription from RNA polymerase II promoter in response to oxidative stress	ISO Inferred from Sequence Orthology more info
response to estrogen stimulus	ISO Inferred from Sequence Orthology more info
response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
response to nicotine	ISO Inferred from Sequence Orthology more info
response to oxidative stress	ISO Inferred from Sequence Orthology more info
response to stimulus	IDA Inferred from Direct Assay more info	PubMed
small GTPase mediated signal transduction	ISO Inferred from Sequence Orthology more info
wound healing involved in inflammatory response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
caveola	ISO Inferred from Sequence Orthology more info
cytosol	ISO Inferred from Sequence Orthology more info
endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
nucleolus	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: heme oxygenase 1

Names: heme oxygenase 1; P32 protein; hemoxygenase

NP_034572.1

EC 1.14.99.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010442.2 → NP_034572.1 heme oxygenase 1

Status: VALIDATED

Source sequence(s)

AA186175, AK150934, BY319630

Consensus CDS

CCDS22423.1

UniProtKB/Swiss-Prot

P14901

UniProtKB/TrEMBL

Q3U5U6

Related

ENSMUSP00000005548, OTTMUSP00000039843, ENSMUST00000005548, OTTMUST00000075866

Conserved Domains (1) summary

cd00232
Location:12 – 218
Blast Score: 553

HemeO; Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000074.6 Reference GRCm38.p1 C57BL/6J

Range

75093618..75100593

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000030.1 Alternate Mm_Celera

Range

79400848..79407824

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01072103.1 (24942..31918)	None
genomic	AC005290.3 (4616..11607)	None	129S6/SvEvTac
genomic	AC084823.11 (104499..111462)	None	C57BL/6J
genomic	CH466525.1	EDL10826.1	mixed
genomic	L37439.1	None
genomic	U70472.1	None
genomic	X56824.1	CAA40159.1
genomic	X56825.1	None
genomic	X56826.1	None
genomic	X56827.1	None
mRNA	AA186175.1	None	C57BL/6J
mRNA	AK150934.1	BAE29970.1	C57BL/6J
mRNA	AK151005.1	BAE30028.1	C57BL/6J
mRNA	AK151012.1	None	C57BL/6J
mRNA	AK151627.1	None	C57BL/6J
mRNA	AK153420.1	BAE31980.1	C57BL/6J
mRNA	AK153516.1	BAE32059.1	C57BL/6J
mRNA	AK153566.1	BAE32100.1	C57BL/6J
mRNA	AK154598.1	BAE32701.1	NOD
mRNA	AK159521.1	BAE35150.1	C57BL/6J
mRNA	AK159870.1	BAE35443.1	C57BL/6J
mRNA	AK159959.1	BAE35514.1	C57BL/6J
mRNA	AK169227.1	BAE40996.1	C57BL/6J
mRNA	BC010757.1	AAH10757.1	FVB/N
mRNA	BY319630.1	None	C57BL/6J
mRNA	M33203.1	AAA39872.1	BALB/c
mRNA	X13356.1	CAA31732.1	BALB/c