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Hmga1 high mobility group AT-hook 1 [ Mus musculus (house mouse) ]

Gene ID: 15361, updated on 8-May-2016
Official Symbol
Hmga1provided by MGI
Official Full Name
high mobility group AT-hook 1provided by MGI
Primary source
MGI:MGI:96160
See related
Ensembl:ENSMUSG00000046711 Vega:OTTMUSG00000028935
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hmgi; Hmgy; Hmgiy; Hmga1a; Hmga1b; AL023995
Summary
This locus encodes a member of the nuclear, non-histone high mobility group protein family. This architectural transcription factor binds to A-T rich DNA sequences and participates in enhanceosome formation, chromatin remodeling and regulation of transcription. This protein functions in many cellular processes, including cell growth and differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
Orthologs
Location:
17 A3.3; 17 14.5 cM
Exon count:
6
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 17 NC_000083.6 (27556574..27563672)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (27693519..27700617)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene predicted gene 16005 Neighboring gene predicted gene 9703 Neighboring gene expressed sequence AI413582 Neighboring gene nudix (nucleotide diphosphate linked moiety X)-type motif 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC102580

Gene Ontology Provided by MGI

Function Evidence Code Pubs
5'-deoxyribose-5-phosphate lyase activity ISO
Inferred from Sequence Orthology
more info
 
DNA-(apurinic or apyrimidinic site) lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
DNA-(apurinic or apyrimidinic site) lyase activity ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
ligand-dependent nuclear receptor transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
peroxisome proliferator activated receptor binding ISO
Inferred from Sequence Orthology
more info
 
retinoic acid receptor binding ISO
Inferred from Sequence Orthology
more info
 
retinoid X receptor binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
senescence-associated heterochromatin focus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
high mobility group protein HMG-I/HMG-Y
Names
high mobility group AT-hook protein 1
high mobility group protein A1
high mobility group protein I

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025427.3NP_001020598.1  high mobility group protein HMG-I/HMG-Y isoform a

    See identical proteins and their annotated locations for NP_001020598.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 5 encode the same isoform (a), also known as isoform I.
    Source sequence(s)
    AK171334, AV018894, BY270784
    Consensus CDS
    CCDS28564.1
    UniProtKB/Swiss-Prot
    P17095
    UniProtKB/TrEMBL
    Q566K0
    Related
    ENSMUSP00000113068, OTTMUSP00000036805, ENSMUST00000117600, OTTMUST00000071708
    Conserved Domains (1) summary
    pfam06217
    Location:487
    GAGA_bind; GAGA binding protein-like family
  2. NM_001039356.2NP_001034445.1  high mobility group protein HMG-I/HMG-Y isoform a

    See identical proteins and their annotated locations for NP_001034445.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 5 encode the same isoform (a), also known as isoform I.
    Source sequence(s)
    AK171334, AV018894, BY270784, GH454882
    Consensus CDS
    CCDS28564.1
    UniProtKB/Swiss-Prot
    P17095
    UniProtKB/TrEMBL
    Q566K0
    Related
    ENSMUSP00000113015, OTTMUSP00000036809, ENSMUST00000118599, OTTMUST00000071712
    Conserved Domains (1) summary
    pfam06217
    Location:487
    GAGA_bind; GAGA binding protein-like family
  3. NM_001166535.1NP_001160007.1  high mobility group protein HMG-I/HMG-Y isoform a

    See identical proteins and their annotated locations for NP_001160007.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 5 encode the same isoform (a), also known as isoform I.
    Source sequence(s)
    AK171334, AV018894, BY165675, BY270784
    Consensus CDS
    CCDS28564.1
    UniProtKB/Swiss-Prot
    P17095
    UniProtKB/TrEMBL
    Q566K0
    Related
    ENSMUSP00000113916, OTTMUSP00000036810, ENSMUST00000119486, OTTMUST00000071713
    Conserved Domains (1) summary
    pfam06217
    Location:487
    GAGA_bind; GAGA binding protein-like family
  4. NM_001166536.1NP_001160008.1  high mobility group protein HMG-I/HMG-Y isoform a

    See identical proteins and their annotated locations for NP_001160008.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 through 5 encode the same isoform (a), also known as isoform I.
    Source sequence(s)
    AK171334, AV018894, BY270784
    Consensus CDS
    CCDS28564.1
    UniProtKB/Swiss-Prot
    P17095
    UniProtKB/TrEMBL
    Q566K0
    Conserved Domains (1) summary
    pfam06217
    Location:487
    GAGA_bind; GAGA binding protein-like family
  5. NM_001166537.1NP_001160009.1  high mobility group protein HMG-I/HMG-Y isoform b

    See identical proteins and their annotated locations for NP_001160009.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 6 through 10 encode the same isoform (b), also known as isoform Y.
    Source sequence(s)
    AK155661, AK171334, AV018894, BM937661, CF730372
    Consensus CDS
    CCDS50044.1
    UniProtKB/Swiss-Prot
    P17095
    UniProtKB/TrEMBL
    Q3TVP0, Q566K0
    Related
    ENSMUSP00000114101, OTTMUSP00000036807, ENSMUST00000118570, OTTMUST00000071710
    Conserved Domains (1) summary
    PRK10475
    Location:3175
    PRK10475; 23S rRNA pseudouridine synthase F; Provisional
  6. NM_001166539.1NP_001160011.1  high mobility group protein HMG-I/HMG-Y isoform b

    See identical proteins and their annotated locations for NP_001160011.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 6 through 10 encode the same isoform (b), also known as isoform Y.
    Source sequence(s)
    AK171334, AV018894, BY270784, GH454882
    Consensus CDS
    CCDS50044.1
    UniProtKB/Swiss-Prot
    P17095
    UniProtKB/TrEMBL
    Q3TVP0, Q566K0
    Conserved Domains (1) summary
    PRK10475
    Location:3175
    PRK10475; 23S rRNA pseudouridine synthase F; Provisional
  7. NM_001166540.1NP_001160012.1  high mobility group protein HMG-I/HMG-Y isoform b

    See identical proteins and their annotated locations for NP_001160012.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 6 through 10 encode the same isoform (b), also known as isoform Y.
    Source sequence(s)
    AK155661, AK171334, AV018894, BY165675, BY270784
    Consensus CDS
    CCDS50044.1
    UniProtKB/Swiss-Prot
    P17095
    UniProtKB/TrEMBL
    Q3TVP0, Q566K0
    Conserved Domains (1) summary
    PRK10475
    Location:3175
    PRK10475; 23S rRNA pseudouridine synthase F; Provisional
  8. NM_001166541.1NP_001160013.1  high mobility group protein HMG-I/HMG-Y isoform b

    See identical proteins and their annotated locations for NP_001160013.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 6 through 10 encode the same isoform (b), also known as isoform Y.
    Source sequence(s)
    AK155661, AK171334, AV018894, BY270784
    Consensus CDS
    CCDS50044.1
    UniProtKB/Swiss-Prot
    P17095
    UniProtKB/TrEMBL
    Q3TVP0, Q566K0
    Related
    ENSMUSP00000110538, OTTMUSP00000036806, ENSMUST00000114888, OTTMUST00000071709
    Conserved Domains (1) summary
    PRK10475
    Location:3175
    PRK10475; 23S rRNA pseudouridine synthase F; Provisional
  9. NM_001166542.1NP_001160014.1  high mobility group protein HMG-I/HMG-Y isoform b

    See identical proteins and their annotated locations for NP_001160014.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 6 through 10 encode the same isoform (b), also known as isoform Y.
    Source sequence(s)
    AK155661, AK171334, AV018894, BY270784
    Consensus CDS
    CCDS50044.1
    UniProtKB/Swiss-Prot
    P17095
    UniProtKB/TrEMBL
    Q3TVP0, Q566K0
    Conserved Domains (1) summary
    PRK10475
    Location:3175
    PRK10475; 23S rRNA pseudouridine synthase F; Provisional
  10. NM_001166543.1NP_001160015.1  high mobility group protein HMG-I/HMG-Y isoform c

    See identical proteins and their annotated locations for NP_001160015.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and uses an alternate, in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a. Variants 11 and 12 encode the same isoform (c).
    Source sequence(s)
    AK171334, AV018894, BY165675, BY270784
    UniProtKB/TrEMBL
    Q3TE85, Q566K0
    Conserved Domains (1) summary
    pfam06217
    Location:4101
    GAGA_bind; GAGA binding protein-like family
  11. NM_001166544.1NP_001160016.1  high mobility group protein HMG-I/HMG-Y isoform c

    See identical proteins and their annotated locations for NP_001160016.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR and uses an alternate, in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a. Variants 11 and 12 encode the same isoform (c).
    Source sequence(s)
    AK171334, AV018894, BY270784
    UniProtKB/TrEMBL
    Q3TE85, Q566K0
    Conserved Domains (1) summary
    pfam06217
    Location:4101
    GAGA_bind; GAGA binding protein-like family
  12. NM_001166545.1NP_001160017.1  high mobility group protein HMG-I/HMG-Y isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR and uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (d) is longer than isoform a.
    Source sequence(s)
    AK171334, AV018894, BY270784, CF951929
    UniProtKB/TrEMBL
    Q566K0
  13. NM_001166546.1NP_001160018.1  high mobility group protein HMG-I/HMG-Y isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform e, which has a longer and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK171334, AV018894, BY270784
    UniProtKB/TrEMBL
    Q566K0
  14. NM_016660.3NP_057869.2  high mobility group protein HMG-I/HMG-Y isoform a

    See identical proteins and their annotated locations for NP_057869.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1 through 5 encode the same isoform (a), also known as isoform I.
    Source sequence(s)
    AK171334, AV018894, BM937661, CF730372
    Consensus CDS
    CCDS28564.1
    UniProtKB/Swiss-Prot
    P17095
    UniProtKB/TrEMBL
    Q566K0
    Related
    ENSMUSP00000113011, OTTMUSP00000036808, ENSMUST00000117254, OTTMUST00000071711
    Conserved Domains (1) summary
    pfam06217
    Location:487
    GAGA_bind; GAGA binding protein-like family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p3 C57BL/6J

    Range
    27556574..27563672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p3 NOD/ShiLtJ

Genomic

  1. NT_187005.1 Reference GRCm38.p3 NOD/ShiLtJ

    Range
    246515..253612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000039.1 Alternate Mm_Celera

    Range
    28108639..28115776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)